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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRPF40A

Summary for PRPF40A

Gene information	Gene symbol	PRPF40A
	Ensembl ID	ENSG00000196504
	Entrez ID	55660
	Gene name	pre-mRNA processing factor 40 homolog A
	Synonyms	FBP-11\|FBP11\|FLAF1\|FLJ20585\|FNBP3\|HIP10\|HYPA\|NY-REN-6\|Prp40
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PRPF40A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.626624	2.18e-06
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.569018	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.414907	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.288305	1.31e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.32529	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.36746	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.629423	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.365408	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.291701	2.57e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.309436	1.83e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.471125	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.427857	1.02e-38
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.321135	1.77e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.340151	8.29e-21
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.340158	3.32e-15
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.492976	1.74e-43

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Expression of PRPF40A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRPF40A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRPF40A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRPF40A	hsa-miR-548ar-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548a-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548ay-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548ae-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548ab	84.7992	NM_017892
PRPF40A	hsa-miR-548ad-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548b-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548i	84.7992	NM_017892
PRPF40A	hsa-miR-548d-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548bb-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548as-5p	84.7992	NM_017892
PRPF40A	hsa-miR-548y	84.7992	NM_017892
PRPF40A	hsa-miR-548at-3p	84.7681	NM_017892
PRPF40A	hsa-miR-548ay-3p	84.7681	NM_017892
PRPF40A	hsa-miR-576-5p	84.4892	NM_017892
PRPF40A	hsa-miR-3162-5p	84.1262	NM_017892
PRPF40A	hsa-miR-29b-3p	84.0609	NM_017892
PRPF40A	hsa-miR-29c-3p	84.0609	NM_017892
PRPF40A	hsa-miR-29a-3p	84.0609	NM_017892
PRPF40A	hsa-miR-1323	83.8151	NM_017892
PRPF40A	hsa-miR-335-3p	83.6965	NM_017892
PRPF40A	hsa-miR-561-3p	83.3435	NM_017892
PRPF40A	hsa-miR-1252-5p	83.0438	NM_017892
PRPF40A	hsa-miR-10527-5p	82.5485	NM_017892
PRPF40A	hsa-miR-105-5p	82.4758	NM_017892
PRPF40A	hsa-miR-7853-5p	82.4758	NM_017892
PRPF40A	hsa-miR-6878-5p	82.4389	NM_017892
PRPF40A	hsa-miR-30e-5p	82.0037	NM_017892
PRPF40A	hsa-miR-30c-5p	82.0037	NM_017892
PRPF40A	hsa-miR-30b-5p	82.0037	NM_017892
PRPF40A	hsa-miR-30a-5p	82.0037	NM_017892
PRPF40A	hsa-miR-30d-5p	82.0037	NM_017892
PRPF40A	hsa-miR-4680-3p	82.0037	NM_017892
PRPF40A	hsa-miR-3662	81.6135	NM_017892
PRPF40A	hsa-miR-138-5p	81.2216	NM_017892
PRPF40A	hsa-miR-5692a	80.8486	NM_017892
PRPF40A	hsa-miR-524-5p	80.4117	NM_017892
PRPF40A	hsa-miR-520d-5p	80.4117	NM_017892
PRPF40A	hsa-miR-10b-3p	80.3969	NM_017892
PRPF40A	hsa-miR-2392	80.1142	NM_017892
PRPF40A	hsa-miR-4251	80.103	NM_017892

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Motifs and transcription factors (TFs) regulating PRPF40A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRPF40A	cisbp__M02645	ETS1 (directAnnotation).
PRPF40A	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
PRPF40A	transfac_pro__M04944	GABPA (directAnnotation).
PRPF40A	transfac_pro__M02913	SP140 (inferredBy_Orthology).
PRPF40A	metacluster_191.5	SPDEF (inferredBy_Orthology).
PRPF40A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PRPF40A	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PRPF40A	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
PRPF40A	metacluster_183.4	ETS1 (inferredBy_Orthology).
PRPF40A	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."