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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRKG1

Summary for PRKG1

Gene information	Gene symbol	PRKG1
	Ensembl ID	ENSG00000185532
	Entrez ID	5592
	Gene name	protein kinase cGMP-dependent 1
	Synonyms	PGK\|PKG\|PKG1\|PRKG1B\|PRKGR1B
	Gene type	protein_coding
	UniProtAcc	Q13976

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Dataset with differentially expressed gene: PRKG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.1438	5.15e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.412555	0.00e+00

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Expression of PRKG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRKG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKG1	hsa-miR-4252	88.3411	NM_001098512
PRKG1	hsa-miR-6516-3p	88.2035	NM_006258
PRKG1	hsa-miR-10524-5p	87.7997	NM_001098512
PRKG1	hsa-miR-6852-3p	87.4969	NM_001098512
PRKG1	hsa-miR-6762-3p	87.1431	NM_001098512
PRKG1	hsa-miR-3133	87.1279	NM_006258
PRKG1	hsa-miR-559	86.7395	NM_006258
PRKG1	hsa-miR-1267	86.7065	NM_006258
PRKG1	hsa-miR-5683	86.702	NM_006258
PRKG1	hsa-miR-124-3p	86.6767	NM_001098512
PRKG1	hsa-miR-506-3p	86.6767	NM_001098512
PRKG1	hsa-miR-3671	86.5903	NM_006258
PRKG1	hsa-miR-3909	86.5834	NM_001098512
PRKG1	hsa-miR-29c-3p	86.2999	NM_001098512
PRKG1	hsa-miR-29b-3p	86.2999	NM_001098512
PRKG1	hsa-miR-29a-3p	86.2999	NM_001098512
PRKG1	hsa-miR-3180-5p	86.0436	NM_001098512
PRKG1	hsa-miR-4274	85.7344	NM_001098512
PRKG1	hsa-miR-224-3p	85.7007	NM_001098512
PRKG1	hsa-miR-522-3p	85.7007	NM_001098512
PRKG1	hsa-miR-130b-5p	85.5687	NM_006258
PRKG1	hsa-miR-6871-3p	85.3885	NM_001098512
PRKG1	hsa-miR-499b-3p	85.3885	NM_001098512
PRKG1	hsa-miR-499a-3p	85.3885	NM_001098512
PRKG1	hsa-miR-4760-3p	85.3117	NM_001098512
PRKG1	hsa-miR-664a-5p	84.8796	NM_001098512
PRKG1	hsa-miR-511-5p	84.7373	NM_001098512
PRKG1	hsa-miR-4511	84.7054	NM_006258
PRKG1	hsa-miR-548t-3p	84.557	NM_001098512
PRKG1	hsa-miR-548aa	84.557	NM_001098512
PRKG1	hsa-miR-548ap-3p	84.557	NM_001098512
PRKG1	hsa-miR-4282	84.5513	NM_006258
PRKG1	hsa-miR-196a-5p	84.5286	NM_006258
PRKG1	hsa-miR-196b-5p	84.5286	NM_006258
PRKG1	hsa-miR-4794	84.2372	NM_001098512
PRKG1	hsa-miR-548ae-5p	84.2197	NM_006258
PRKG1	hsa-miR-548bb-5p	84.2197	NM_006258
PRKG1	hsa-miR-548ad-5p	84.2197	NM_006258
PRKG1	hsa-miR-548a-5p	84.2197	NM_006258
PRKG1	hsa-miR-548o-5p	84.2197	NM_006258
PRKG1	hsa-miR-548am-5p	84.2197	NM_006258
PRKG1	hsa-miR-548as-5p	84.2197	NM_006258
PRKG1	hsa-miR-548j-5p	84.2197	NM_006258
PRKG1	hsa-miR-548ak	84.2197	NM_006258
PRKG1	hsa-miR-548ay-5p	84.2197	NM_006258
PRKG1	hsa-miR-548c-5p	84.2197	NM_006258
PRKG1	hsa-miR-548w	84.2197	NM_006258
PRKG1	hsa-miR-548ar-5p	84.2197	NM_006258
PRKG1	hsa-miR-548b-5p	84.2197	NM_006258
PRKG1	hsa-miR-548ap-5p	84.2197	NM_006258

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Motifs and transcription factors (TFs) regulating PRKG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKG1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
PRKG1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PRKG1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
PRKG1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PRKG1	transfac_pro__M04617	ZBTB7A (directAnnotation).
PRKG1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PRKG1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
PRKG1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PRKG1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PRKG1	transfac_pro__M07387	ZBTB7A (directAnnotation).
PRKG1	transfac_pro__M07436	WT1 (directAnnotation).
PRKG1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PRKG1	transfac_pro__M00716	ZBTB14 (directAnnotation).
PRKG1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PRKG1	hdpi__HIP2	UBE2K (directAnnotation).
PRKG1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PRKG1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PRKG1	transfac_pro__M04893	TAF1 (directAnnotation).
PRKG1	transfac_pro__M03876	ZBTB33 (directAnnotation).
PRKG1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PRKG1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PRKG1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PRKG1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PRKG1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PRKG1	transfac_pro__M02089	E2F3 (directAnnotation).
PRKG1	transfac_pro__M02898	SMAD3 (directAnnotation).
PRKG1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PRKG1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PRKG1	hdpi__NRL	NRL (directAnnotation).
PRKG1	transfac_pro__M00430	E2F1 (directAnnotation).
PRKG1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PRKG1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PRKG1	transfac_pro__M07329	SP7 (directAnnotation).
PRKG1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
PRKG1	transfac_pro__M07397	ZNF148 (directAnnotation).
PRKG1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PRKG1	cisbp__M07938	E2F1 (directAnnotation).
PRKG1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PRKG1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PRKG1	metacluster_3.14	WT1; WT1 (directAnnotation).
PRKG1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PRKG1	transfac_pro__M01837	KLF11 (directAnnotation).
PRKG1	hdpi__TP73	TP73 (directAnnotation).
PRKG1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PRKG1	transfac_pro__M07310	SP5 (directAnnotation).
PRKG1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PRKG1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PRKG1	jaspar__MA0748.2	YY2 (directAnnotation).
PRKG1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
PRKG1	metacluster_7.13	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."