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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: PRDM1

Summary for PRDM1

Gene information	Gene symbol	PRDM1
	Ensembl ID	ENSG00000057657
	Entrez ID	639
	Gene name	PR/SET domain 1
	Synonyms	BLIMP1\|PRDI-BF1
	Gene type	protein_coding
	UniProtAcc	O75626

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Dataset with differentially expressed gene: PRDM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.412279	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.43191	2.65e-23
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.386065	1.29e-20
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.527757	2.17e-41
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.665163	9.62e-36
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.726858	6.44e-36
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	0.290128	3.31e-41
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.739389	6.36e-22
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.540044	5.22e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.2568	3.50e-30
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.330202	0.00e+00

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Expression of PRDM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRDM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRDM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRDM1	hsa-miR-3125	89.1095	NM_001198
PRDM1	hsa-miR-137-3p	88.6173	NM_001198
PRDM1	hsa-miR-3688-5p	88.6106	NM_001198
PRDM1	hsa-miR-1283	88.5541	NM_001198
PRDM1	hsa-miR-7849-3p	88.5532	NM_001198
PRDM1	hsa-miR-5589-3p	88.1748	NM_001198
PRDM1	hsa-miR-520a-5p	87.9692	NM_001198
PRDM1	hsa-miR-525-5p	87.9692	NM_001198
PRDM1	hsa-miR-1277-5p	87.7546	NM_001198
PRDM1	hsa-miR-3163	87.5806	NM_001198
PRDM1	hsa-miR-6083	87.2987	NM_001198
PRDM1	hsa-miR-513b-3p	87.0422	NM_001198
PRDM1	hsa-miR-1248	86.9431	NM_001198
PRDM1	hsa-miR-223-3p	86.6049	NM_001198
PRDM1	hsa-miR-4803	86.229	NM_001198
PRDM1	hsa-miR-372-5p	85.7171	NM_001198
PRDM1	hsa-miR-24-3p	85.6652	NM_001198
PRDM1	hsa-miR-4747-5p	85.5109	NM_001198
PRDM1	hsa-miR-5196-5p	85.5109	NM_001198
PRDM1	hsa-miR-6868-3p	85.0024	NM_001198
PRDM1	hsa-miR-4437	84.4654	NM_001198
PRDM1	hsa-miR-3173-5p	84.4531	NM_001198
PRDM1	hsa-miR-6799-3p	84.4531	NM_001198
PRDM1	hsa-miR-3121-3p	84.0276	NM_001198
PRDM1	hsa-miR-4279	84.0203	NM_001198
PRDM1	hsa-miR-6768-5p	83.752	NM_001198
PRDM1	hsa-miR-6715b-3p	83.5702	NM_001198
PRDM1	hsa-miR-6715a-3p	82.9555	NM_001198
PRDM1	hsa-miR-211-5p	82.9101	NM_001198
PRDM1	hsa-miR-204-5p	82.9101	NM_001198
PRDM1	hsa-miR-5587-5p	82.5833	NM_001198
PRDM1	hsa-miR-3065-5p	82.4308	NM_001198
PRDM1	hsa-miR-8084	82.2656	NM_001198
PRDM1	hsa-miR-10527-5p	82.1959	NM_001198
PRDM1	hsa-miR-4425	81.437	NM_001198
PRDM1	hsa-miR-429	81.3596	NM_001198
PRDM1	hsa-miR-200c-3p	81.3596	NM_001198
PRDM1	hsa-miR-200b-3p	81.3596	NM_001198
PRDM1	hsa-miR-942-3p	80.6911	NM_001198
PRDM1	hsa-miR-8068	80.4962	NM_001198
PRDM1	hsa-miR-7853-5p	80.3793	NM_001198
PRDM1	hsa-miR-5002-5p	80.3258	NM_001198
PRDM1	hsa-miR-568	80.0231	NM_001198

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Motifs and transcription factors (TFs) regulating PRDM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRDM1	transfac_pro__M00691	ATF1 (directAnnotation).
PRDM1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PRDM1	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
PRDM1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
PRDM1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
PRDM1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
PRDM1	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).
PRDM1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PRDM1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
PRDM1	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
PRDM1	transfac_pro__M06516	ZNF418 (directAnnotation).
PRDM1	jaspar__MA1125.1	ZNF384 (directAnnotation).
PRDM1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
PRDM1	transfac_pro__M05421	MYNN (inferredBy_Orthology).
PRDM1	taipale_tf_pairs__GCM1_HOXB13_RTGCGGGTAATAAAN_CAP	GCM1; HOXB13 (directAnnotation).
PRDM1	transfac_pro__M04748	GABPA (directAnnotation).
PRDM1	taipale_tf_pairs__GCM1_MAX_RTGCGGGNNNNNNNCACGTGN_CAP_repr	GCM1; MAX (directAnnotation).
PRDM1	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
PRDM1	metacluster_22.19	NFE2 (directAnnotation).
PRDM1	metacluster_22.18	BACH2 (inferredBy_Orthology).
PRDM1	metacluster_22.37	BACH1 (directAnnotation).
PRDM1	metacluster_22.36	BACH2 (directAnnotation).
PRDM1	metacluster_22.34	BACH2 (directAnnotation).
PRDM1	metacluster_22.20	MAFG (directAnnotation).
PRDM1	metacluster_22.35	MAFK (directAnnotation).
PRDM1	cisbp__M01815	CEBPE (inferredBy_Orthology).
PRDM1	metacluster_22.13	MAFK (inferredBy_Orthology).
PRDM1	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
PRDM1	metacluster_22.33	MAFK (inferredBy_Orthology).
PRDM1	metacluster_22.32	NFE2L2 (directAnnotation).
PRDM1	metacluster_32.24	ZNF287 (directAnnotation).
PRDM1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
PRDM1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PRDM1	hdpi__TIMELESS	TIMELESS (directAnnotation).
PRDM1	taipale_tf_pairs__HOXB2_SOX15_ACAAWRSNNNNYMATTA_CAP_repr	HOXB2; SOX15 (directAnnotation).
PRDM1	metacluster_58.10	PAX3; PAX7 (directAnnotation).
PRDM1	transfac_pro__M06413	ZNF573 (directAnnotation).
PRDM1	metacluster_175.6	GRHL1; GRHL1; GRHL1; GRHL1; TFCP2 (directAnnotation).
PRDM1	tfdimers__MD00042	CRX; POU2F1 (directAnnotation).
PRDM1	jaspar__MA0724.1	VENTX (directAnnotation).
PRDM1	transfac_pro__M05601	FIZ1 (directAnnotation).
PRDM1	transfac_pro__M01081	ZNF628 (directAnnotation).
PRDM1	metacluster_155.10	ZNF263; ZNF684; ZNF684; ZNF684; ZNF684 (directAnnotation).
PRDM1	tfdimers__MD00335	FOXP3; NKX2-1 (directAnnotation).
PRDM1	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
PRDM1	metacluster_135.11	NR2C2 (directAnnotation).
PRDM1	transfac_pro__M05379	ZNF740 (inferredBy_Orthology).
PRDM1	dbtfbs__HLF_HepG2_ENCSR528PSI_merged_N1	HLF (directAnnotation).
PRDM1	transfac_pro__M06881	ZNF549 (directAnnotation).
PRDM1	transfac_pro__M00326	PAX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
PRDM1	metacluster_2.7	up	Malignant cells	GSE161801_PI	post
PRDM1	metacluster_2.9	up	Malignant cells	GSE161801_PI	post
PRDM1	metacluster_2.9	up	Malignant cells	GSE161801_PI	pre
PRDM1	metacluster_2.9	up	CD8+ T cells	GSE207422_Sin	post
PRDM1	metacluster_187.2	up	CD4+ T cells	PMID34715028	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."