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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP2R5E

Summary for PPP2R5E

Gene information	Gene symbol	PPP2R5E
	Ensembl ID	ENSG00000154001
	Entrez ID	5529
	Gene name	protein phosphatase 2 regulatory subunit B'epsilon
	Synonyms	B56E\|B56epsilon
	Gene type	protein_coding
	UniProtAcc	Q16537

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Dataset with differentially expressed gene: PPP2R5E

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.411736	3.24e-25

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Expression of PPP2R5E in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP2R5E

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP2R5E

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP2R5E	hsa-miR-23a-3p	86.2594	NM_001282179
PPP2R5E	hsa-miR-23b-3p	86.2594	NM_001282179
PPP2R5E	hsa-miR-5698	85.8399	NM_001282179
PPP2R5E	hsa-miR-6870-5p	85.8399	NM_001282179
PPP2R5E	hsa-miR-7111-5p	85.8399	NM_001282179
PPP2R5E	hsa-miR-4723-5p	85.8399	NM_001282179
PPP2R5E	hsa-miR-548aw	84.9667	NM_001282179
PPP2R5E	hsa-miR-1283	84.512	NM_001282179
PPP2R5E	hsa-miR-576-3p	83.7491	NM_001282179
PPP2R5E	hsa-miR-1265	83.689	NM_001282179
PPP2R5E	hsa-miR-381-3p	83.3928	NM_001282179
PPP2R5E	hsa-miR-300	83.3928	NM_001282179
PPP2R5E	hsa-miR-7-2-3p	82.8621	NM_001282179
PPP2R5E	hsa-miR-7-1-3p	82.8621	NM_001282179
PPP2R5E	hsa-miR-338-3p	82.3851	NM_001282179
PPP2R5E	hsa-miR-1468-3p	81.512	NM_001282179
PPP2R5E	hsa-miR-548e-5p	81.4736	NM_001282179
PPP2R5E	hsa-miR-409-3p	81.0404	NM_001282179
PPP2R5E	hsa-miR-4482-3p	80.8251	NM_001282179
PPP2R5E	hsa-miR-3163	80.7931	NM_001282179
PPP2R5E	hsa-miR-4262	80.767	NM_001282179
PPP2R5E	hsa-miR-4774-5p	80.3185	NM_001282179
PPP2R5E	hsa-miR-302a-5p	80.2044	NM_001282179

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Motifs and transcription factors (TFs) regulating PPP2R5E

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP2R5E	metacluster_135.11	NR2C2 (directAnnotation).
PPP2R5E	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PPP2R5E	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PPP2R5E	metacluster_7.13	ZFX (directAnnotation).
PPP2R5E	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PPP2R5E	cisbp__M00968	MTF2 (directAnnotation).
PPP2R5E	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PPP2R5E	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PPP2R5E	cisbp__M00341	PAX6 (directAnnotation).
PPP2R5E	metacluster_198.3	ZFP64 (directAnnotation).
PPP2R5E	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PPP2R5E	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PPP2R5E	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PPP2R5E	cisbp__M00788	ZFY (inferredBy_Orthology).
PPP2R5E	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PPP2R5E	hdpi__ZNF304	ZNF304 (directAnnotation).
PPP2R5E	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PPP2R5E	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PPP2R5E	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PPP2R5E	transfac_pro__M01199	TRIM28 (directAnnotation).
PPP2R5E	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PPP2R5E	metacluster_151.2	ZNF23 (directAnnotation).
PPP2R5E	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PPP2R5E	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPP2R5E	transfac_pro__M03806	ZBTB7C (directAnnotation).
PPP2R5E	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."