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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPM1E

Summary for PPM1E

Gene information	Gene symbol	PPM1E
	Ensembl ID	ENSG00000175175
	Entrez ID	22843
	Gene name	protein phosphatase, Mg2+/Mn2+ dependent 1E
	Synonyms	CaMKP-N\|KIAA1072\|POPX1\|PP2CH
	Gene type	protein_coding
	UniProtAcc	Q8WY54

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Dataset with differentially expressed gene: PPM1E

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.250521	1.45e-03

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Expression of PPM1E in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPM1E

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPM1E

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPM1E	hsa-miR-3678-3p	87.0077	NM_014906
PPM1E	hsa-miR-944	86.8512	NM_014906
PPM1E	hsa-miR-4668-3p	86.6692	NM_014906
PPM1E	hsa-miR-6835-3p	86.4316	NM_014906
PPM1E	hsa-miR-513a-3p	86.0513	NM_014906
PPM1E	hsa-miR-513c-3p	86.0513	NM_014906
PPM1E	hsa-miR-200b-5p	85.8317	NM_014906
PPM1E	hsa-miR-200a-5p	85.8317	NM_014906
PPM1E	hsa-miR-107	85.7367	NM_014906
PPM1E	hsa-miR-103a-3p	85.7367	NM_014906
PPM1E	hsa-miR-6807-5p	85.6519	NM_014906
PPM1E	hsa-miR-6844	85.4632	NM_014906
PPM1E	hsa-miR-4732-5p	84.9813	NM_014906
PPM1E	hsa-miR-1275	84.9068	NM_014906
PPM1E	hsa-miR-3606-3p	84.8794	NM_014906
PPM1E	hsa-miR-3682-5p	84.8101	NM_014906
PPM1E	hsa-miR-1250-3p	84.8041	NM_014906
PPM1E	hsa-miR-3658	84.7224	NM_014906
PPM1E	hsa-miR-4714-5p	84.6397	NM_014906
PPM1E	hsa-miR-5692a	84.2823	NM_014906
PPM1E	hsa-miR-570-3p	84.269	NM_014906
PPM1E	hsa-miR-335-3p	84.2301	NM_014906
PPM1E	hsa-miR-4539	83.828	NM_014906
PPM1E	hsa-miR-4529-3p	83.8214	NM_014906
PPM1E	hsa-miR-4286	82.8799	NM_014906
PPM1E	hsa-miR-3163	82.5671	NM_014906
PPM1E	hsa-miR-7515	82.4246	NM_014906
PPM1E	hsa-miR-1255b-2-3p	82.338	NM_014906
PPM1E	hsa-miR-323b-3p	82.271	NM_014906
PPM1E	hsa-miR-12113	81.8117	NM_014906
PPM1E	hsa-miR-6830-5p	81.7914	NM_014906
PPM1E	hsa-miR-12124	81.6125	NM_014906
PPM1E	hsa-miR-4324	81.6076	NM_014906
PPM1E	hsa-miR-181b-2-3p	81.3871	NM_014906
PPM1E	hsa-miR-181b-3p	81.3871	NM_014906
PPM1E	hsa-miR-4423-3p	81.1267	NM_014906
PPM1E	hsa-miR-510-3p	81.0562	NM_014906
PPM1E	hsa-miR-4665-5p	80.9295	NM_014906
PPM1E	hsa-miR-197-3p	80.9232	NM_014906
PPM1E	hsa-miR-548e-5p	80.8538	NM_014906
PPM1E	hsa-miR-20a-3p	80.7749	NM_014906
PPM1E	hsa-miR-3938	80.5986	NM_014906
PPM1E	hsa-miR-383-5p	80.5716	NM_014906
PPM1E	hsa-miR-645	80.4817	NM_014906
PPM1E	hsa-miR-6511b-3p	80.4061	NM_014906
PPM1E	hsa-miR-6511a-3p	80.4061	NM_014906
PPM1E	hsa-miR-378a-5p	80.3359	NM_014906
PPM1E	hsa-miR-4289	80.2721	NM_014906
PPM1E	hsa-miR-3646	80.2146	NM_014906

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Motifs and transcription factors (TFs) regulating PPM1E

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPM1E	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
PPM1E	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PPM1E	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PPM1E	transfac_pro__M04617	ZBTB7A (directAnnotation).
PPM1E	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PPM1E	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
PPM1E	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PPM1E	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PPM1E	transfac_pro__M07387	ZBTB7A (directAnnotation).
PPM1E	transfac_pro__M07436	WT1 (directAnnotation).
PPM1E	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PPM1E	transfac_pro__M00716	ZBTB14 (directAnnotation).
PPM1E	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PPM1E	hdpi__HIP2	UBE2K (directAnnotation).
PPM1E	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PPM1E	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PPM1E	transfac_pro__M04893	TAF1 (directAnnotation).
PPM1E	transfac_pro__M03876	ZBTB33 (directAnnotation).
PPM1E	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PPM1E	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PPM1E	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PPM1E	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPM1E	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."