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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPM1B

Summary for PPM1B

Gene information	Gene symbol	PPM1B
	Ensembl ID	ENSG00000138032
	Entrez ID	5495
	Gene name	protein phosphatase, Mg2+/Mn2+ dependent 1B
	Synonyms	PP2CB\|PP2CBETA\|PPC2BETAX
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPM1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.334616	2.83e-28

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Expression of PPM1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPM1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPM1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPM1B	hsa-miR-4269	87.0343	NM_177968
PPM1B	hsa-miR-4635	86.4391	NM_177968
PPM1B	hsa-miR-5689	86.006	NM_177969
PPM1B	hsa-miR-4427	84.5854	NM_177969
PPM1B	hsa-miR-548g-5p	84.574	NM_177968
PPM1B	hsa-miR-548aj-5p	84.574	NM_177968
PPM1B	hsa-miR-548x-5p	84.574	NM_177968
PPM1B	hsa-miR-548f-5p	84.574	NM_177968
PPM1B	hsa-miR-512-5p	84.4957	NM_001033557
PPM1B	hsa-miR-29b-2-5p	84.4887	NM_177968
PPM1B	hsa-miR-487a-3p	84.4738	NM_177968
PPM1B	hsa-miR-154-3p	84.4738	NM_177968
PPM1B	hsa-miR-4475	84.2452	NM_177968
PPM1B	hsa-miR-3662	84.228	NM_177968
PPM1B	hsa-miR-499a-3p	83.7148	NM_177968
PPM1B	hsa-miR-499b-3p	83.7148	NM_177968
PPM1B	hsa-miR-548aw	83.5492	NM_177968
PPM1B	hsa-miR-10395-3p	83.3844	NM_177968
PPM1B	hsa-miR-200c-3p	83.106	NM_177968
PPM1B	hsa-miR-200b-3p	83.106	NM_177968
PPM1B	hsa-miR-429	83.106	NM_177968
PPM1B	hsa-miR-380-5p	83.0258	NM_177969
PPM1B	hsa-miR-4429	82.7347	NM_177968
PPM1B	hsa-miR-320b	82.7347	NM_177968
PPM1B	hsa-miR-320d	82.7347	NM_177968
PPM1B	hsa-miR-320a-3p	82.7347	NM_177968
PPM1B	hsa-miR-320c	82.7347	NM_177968
PPM1B	hsa-miR-3689f	82.5847	NM_177968
PPM1B	hsa-miR-3689e	82.5847	NM_177968
PPM1B	hsa-miR-3689a-5p	82.5847	NM_177968
PPM1B	hsa-miR-3689b-5p	82.5847	NM_177968
PPM1B	hsa-miR-6507-5p	82.4409	NM_177968
PPM1B	hsa-miR-3671	82.1693	NM_177969
PPM1B	hsa-miR-374a-5p	81.8012	NM_177968
PPM1B	hsa-miR-216a-5p	81.6033	NM_001033557
PPM1B	hsa-miR-181b-3p	81.3565	NM_177968
PPM1B	hsa-miR-181b-2-3p	81.3565	NM_177968
PPM1B	hsa-miR-8485	80.6312	NM_177969
PPM1B	hsa-miR-7157-5p	80.6126	NM_177968
PPM1B	hsa-miR-545-3p	80.6009	NM_001033557
PPM1B	hsa-miR-4310	80.5479	NM_177968
PPM1B	hsa-miR-1468-3p	80.276	NM_177968
PPM1B	hsa-miR-6509-5p	80.11	NM_177968
PPM1B	hsa-miR-4742-3p	80.0572	NM_177968

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Motifs and transcription factors (TFs) regulating PPM1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPM1B	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PPM1B	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PPM1B	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
PPM1B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PPM1B	metacluster_7.13	ZFX (directAnnotation).
PPM1B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PPM1B	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PPM1B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PPM1B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPM1B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PPM1B	cisbp__M00249	WT1 (directAnnotation).
PPM1B	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PPM1B	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PPM1B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PPM1B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."