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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLXDC2

Summary for PLXDC2

Gene information	Gene symbol	PLXDC2
	Ensembl ID	ENSG00000120594
	Entrez ID	84898
	Gene name	plexin domain containing 2
	Synonyms	FLJ14623\|TEM7R
	Gene type	protein_coding
	UniProtAcc	Q6UX71

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Dataset with differentially expressed gene: PLXDC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.454228	4.68e-12
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.443131	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.487821	4.49e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.444577	1.89e-27
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.344575	3.07e-23
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.664052	0.00e+00

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Expression of PLXDC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLXDC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLXDC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLXDC2	hsa-miR-20a-5p	90.14	NM_001282736
PLXDC2	hsa-miR-106a-5p	89.9871	NM_001282736
PLXDC2	hsa-miR-204-5p	89.6153	NM_001282736
PLXDC2	hsa-miR-211-5p	89.6153	NM_001282736
PLXDC2	hsa-miR-6742-3p	89.4112	NM_032812
PLXDC2	hsa-miR-550a-3p	89.3795	NM_032812
PLXDC2	hsa-miR-939-3p	89.3026	NM_032812
PLXDC2	hsa-miR-1468-3p	89.0979	NM_001282736
PLXDC2	hsa-miR-6783-5p	88.7597	NM_032812
PLXDC2	hsa-miR-93-5p	88.5061	NM_001282736
PLXDC2	hsa-miR-519d-3p	88.5061	NM_001282736
PLXDC2	hsa-miR-17-5p	88.5061	NM_001282736
PLXDC2	hsa-miR-20b-5p	88.5061	NM_001282736
PLXDC2	hsa-miR-10527-5p	88.4479	NM_001282736
PLXDC2	hsa-miR-7154-5p	87.7282	NM_032812
PLXDC2	hsa-miR-4312	87.564	NM_032812
PLXDC2	hsa-miR-450b-5p	87.4058	NM_032812
PLXDC2	hsa-miR-1277-5p	87.3442	NM_032812
PLXDC2	hsa-miR-3143	87.3281	NM_032812
PLXDC2	hsa-miR-4742-5p	87.2006	NM_032812
PLXDC2	hsa-miR-200c-5p	86.8706	NM_032812
PLXDC2	hsa-miR-6507-5p	86.8112	NM_032812
PLXDC2	hsa-miR-4712-5p	86.7889	NM_001282736
PLXDC2	hsa-miR-770-5p	86.7889	NM_001282736
PLXDC2	hsa-miR-5787	86.6969	NM_032812
PLXDC2	hsa-miR-3163	86.621	NM_032812
PLXDC2	hsa-miR-4302	86.3819	NM_032812
PLXDC2	hsa-miR-3646	86.2408	NM_032812
PLXDC2	hsa-miR-340-5p	86.1715	NM_032812
PLXDC2	hsa-miR-4325	86.1375	NM_032812
PLXDC2	hsa-miR-541-5p	85.2961	NM_032812
PLXDC2	hsa-miR-367-3p	85.1211	NM_001282736
PLXDC2	hsa-miR-4720-5p	85.1034	NM_001282736
PLXDC2	hsa-miR-5010-3p	85.0914	NM_032812
PLXDC2	hsa-miR-137-3p	85.0585	NM_001282736
PLXDC2	hsa-miR-5588-5p	84.8755	NM_001282736
PLXDC2	hsa-miR-4799-3p	84.8755	NM_001282736
PLXDC2	hsa-miR-4474-5p	84.8584	NM_001282736
PLXDC2	hsa-miR-302a-5p	84.5349	NM_001282736
PLXDC2	hsa-miR-6805-3p	83.9092	NM_001282736
PLXDC2	hsa-miR-5691	83.9092	NM_001282736
PLXDC2	hsa-miR-3133	83.7289	NM_032812
PLXDC2	hsa-miR-15b-3p	83.6696	NM_032812
PLXDC2	hsa-miR-8076	83.4157	NM_032812
PLXDC2	hsa-miR-8073	83.3413	NM_001282736
PLXDC2	hsa-miR-221-5p	83.3413	NM_001282736
PLXDC2	hsa-miR-4656	83.0448	NM_032812
PLXDC2	hsa-miR-643	82.8947	NM_032812
PLXDC2	hsa-miR-3924	82.8928	NM_032812
PLXDC2	hsa-miR-522-3p	82.8612	NM_032812

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Motifs and transcription factors (TFs) regulating PLXDC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLXDC2	cisbp__M01815	CEBPE (inferredBy_Orthology).
PLXDC2	metacluster_32.24	ZNF287 (directAnnotation).
PLXDC2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PLXDC2	transfac_pro__M04916	TAF1 (directAnnotation).
PLXDC2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PLXDC2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PLXDC2	transfac_pro__M04887	TCF12 (directAnnotation).
PLXDC2	hocomoco__ZN652_HUMAN.H11MO.0.D	ZNF652 (directAnnotation).
PLXDC2	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
PLXDC2	metacluster_168.4	ZNF652 (directAnnotation).
PLXDC2	tfdimers__MD00515	ARID3A; KLF4 (directAnnotation).
PLXDC2	homer__TWGTCTGV_Smad3	SMAD3 (inferredBy_Orthology).
PLXDC2	jaspar__MA0035.4	GATA1 (directAnnotation).
PLXDC2	transfac_pro__M06728	PRDM5 (directAnnotation).
PLXDC2	hdpi__CBFB	CBFB (directAnnotation).
PLXDC2	hdpi__GTF3C2	GTF3C2 (directAnnotation).
PLXDC2	transfac_pro__M03806	ZBTB7C (directAnnotation).
PLXDC2	hdpi__FEZF2	FEZF2 (directAnnotation).
PLXDC2	metacluster_198.3	ZFP64 (directAnnotation).
PLXDC2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PLXDC2	hdpi__NRL	NRL (directAnnotation).
PLXDC2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PLXDC2	tfdimers__MD00483	ZBTB14 (directAnnotation).
PLXDC2	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
PLXDC2	metacluster_155.11	SPZ1 (directAnnotation).
PLXDC2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PLXDC2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PLXDC2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PLXDC2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PLXDC2	transfac_pro__M04893	TAF1 (directAnnotation).
PLXDC2	transfac_public__M00005	TFAP4 (directAnnotation).
PLXDC2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
PLXDC2	jaspar__MA0131.2	HINFP (directAnnotation).
PLXDC2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PLXDC2	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
PLXDC2	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
PLXDC2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."