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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLPP3

Summary for PLPP3

Gene information	Gene symbol	PLPP3
	Ensembl ID	ENSG00000162407
	Entrez ID	8613
	Gene name	phospholipid phosphatase 3
	Synonyms	LPP3\|PAP-2b\|PPAP2B
	Gene type	protein_coding
	UniProtAcc	O14495

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Dataset with differentially expressed gene: PLPP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.357337	1.55e-03

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Expression of PLPP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLPP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLPP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLPP3	hsa-miR-3120-5p	85.618	NM_003713
PLPP3	hsa-miR-640	85.1306	NM_003713
PLPP3	hsa-miR-374a-5p	84.7744	NM_003713
PLPP3	hsa-miR-374b-5p	84.6731	NM_003713
PLPP3	hsa-miR-4753-5p	84.6364	NM_003713
PLPP3	hsa-miR-8068	84.5721	NM_003713
PLPP3	hsa-miR-300	84.4353	NM_003713
PLPP3	hsa-miR-381-3p	84.4353	NM_003713
PLPP3	hsa-miR-4793-5p	84.3282	NM_003713
PLPP3	hsa-miR-4446-5p	83.9739	NM_003713
PLPP3	hsa-miR-374c-5p	83.7942	NM_003713
PLPP3	hsa-miR-655-3p	83.7942	NM_003713
PLPP3	hsa-miR-208a-5p	82.6962	NM_003713
PLPP3	hsa-miR-513a-5p	82.3494	NM_003713
PLPP3	hsa-miR-675-3p	82.2124	NM_003713
PLPP3	hsa-miR-4503	81.6459	NM_003713

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Motifs and transcription factors (TFs) regulating PLPP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLPP3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PLPP3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PLPP3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PLPP3	cisbp__M00968	MTF2 (directAnnotation).
PLPP3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PLPP3	cisbp__M00341	PAX6 (directAnnotation).
PLPP3	metacluster_198.3	ZFP64 (directAnnotation).
PLPP3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PLPP3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PLPP3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PLPP3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PLPP3	metacluster_175.1	ZNF283 (directAnnotation).
PLPP3	hdpi__ZNF304	ZNF304 (directAnnotation).
PLPP3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PLPP3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PLPP3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PLPP3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PLPP3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PLPP3	transfac_pro__M03806	ZBTB7C (directAnnotation).
PLPP3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."