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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PIKFYVE

Summary for PIKFYVE

Gene information	Gene symbol	PIKFYVE
	Ensembl ID	ENSG00000115020
	Entrez ID	200576
	Gene name	phosphoinositide kinase, FYVE-type zinc finger containing
	Synonyms	FAB1\|KIAA0981\|MGC40423\|p235\|PIP5K\|PIP5K3\|ZFYVE29
	Gene type	protein_coding
	UniProtAcc	Q9Y2I7

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Dataset with differentially expressed gene: PIKFYVE

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.411129	4.03e-18

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Expression of PIKFYVE in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PIKFYVE

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PIKFYVE

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PIKFYVE	hsa-miR-153-5p	87.057	NM_015040
PIKFYVE	hsa-miR-6736-3p	87.0461	NM_015040
PIKFYVE	hsa-miR-3127-3p	86.2846	NM_015040
PIKFYVE	hsa-miR-6756-3p	86.2846	NM_015040
PIKFYVE	hsa-miR-3942-3p	86.204	NM_015040
PIKFYVE	hsa-miR-6825-5p	85.8723	NM_001178000
PIKFYVE	hsa-miR-590-3p	85.1717	NM_015040
PIKFYVE	hsa-miR-200a-3p	84.9287	NM_015040
PIKFYVE	hsa-miR-141-3p	84.9287	NM_015040
PIKFYVE	hsa-miR-5007-3p	84.4947	NM_015040
PIKFYVE	hsa-miR-508-3p	84.113	NM_015040
PIKFYVE	hsa-miR-144-3p	83.9459	NM_015040
PIKFYVE	hsa-miR-5585-3p	83.7729	NM_015040
PIKFYVE	hsa-miR-3148	83.1024	NM_015040
PIKFYVE	hsa-miR-3155b	83.0614	NM_015040
PIKFYVE	hsa-miR-3155a	83.0614	NM_015040
PIKFYVE	hsa-miR-362-5p	82.6923	NM_015040
PIKFYVE	hsa-miR-500b-5p	82.6923	NM_015040
PIKFYVE	hsa-miR-95-5p	82.6368	NM_015040
PIKFYVE	hsa-miR-4682	82.4225	NM_015040
PIKFYVE	hsa-miR-6875-3p	81.9416	NM_015040
PIKFYVE	hsa-miR-3613-3p	81.6265	NM_015040
PIKFYVE	hsa-miR-5009-3p	81.272	NM_015040
PIKFYVE	hsa-miR-539-5p	81.1031	NM_015040
PIKFYVE	hsa-miR-548ar-3p	81.0964	NM_015040
PIKFYVE	hsa-miR-302e	80.7627	NM_015040
PIKFYVE	hsa-miR-6839-3p	80.7155	NM_001178000
PIKFYVE	hsa-miR-12116	80.7078	NM_001178000
PIKFYVE	hsa-miR-302f	80.5875	NM_015040
PIKFYVE	hsa-miR-548bc	80.3813	NM_015040
PIKFYVE	hsa-miR-548az-3p	80.3813	NM_015040
PIKFYVE	hsa-miR-548f-3p	80.3813	NM_015040
PIKFYVE	hsa-miR-548e-3p	80.3813	NM_015040
PIKFYVE	hsa-miR-519e-5p	80.3376	NM_015040
PIKFYVE	hsa-miR-515-5p	80.3376	NM_015040
PIKFYVE	hsa-miR-1283	80.3134	NM_015040
PIKFYVE	hsa-miR-1303	80.1327	NM_001178000

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Motifs and transcription factors (TFs) regulating PIKFYVE

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PIKFYVE	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
PIKFYVE	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PIKFYVE	cisbp__M00249	WT1 (directAnnotation).
PIKFYVE	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PIKFYVE	cisbp__M00968	MTF2 (directAnnotation).
PIKFYVE	cisbp__M00809	PRDM11 (inferredBy_Orthology).
PIKFYVE	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PIKFYVE	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PIKFYVE	transfac_pro__M01122	ZNF219 (directAnnotation).
PIKFYVE	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PIKFYVE	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."