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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: PICALM

Summary for PICALM

Gene informationGene symbol

PICALM

Ensembl ID

ENSG00000073921

Entrez ID

8301

Gene namephosphatidylinositol binding clathrin assembly protein
SynonymsCALM|CLTH
Gene typeprotein_coding
UniProtAcc

Q13492


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Dataset with differentially expressed gene: PICALM

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreErythrocytes0.3472993.80e-11

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.2647891.45e-11

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Expression of PICALM in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to PICALM

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PICALM

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
PICALMhsa-miR-6807-3p84.2835NM_001008660
PICALMhsa-miR-5187-3p84.2513NM_001206946
PICALMhsa-miR-503-3p84.2319NM_001206946
PICALMhsa-miR-511-5p84.1656NM_001206946
PICALMhsa-miR-1-3p83.7178NM_001008660
PICALMhsa-miR-61383.7178NM_001008660
PICALMhsa-miR-20683.7178NM_001008660
PICALMhsa-miR-6833-5p83.3057NM_001008660
PICALMhsa-miR-217-5p83.2564NM_001008660
PICALMhsa-miR-509-5p83.2564NM_001008660
PICALMhsa-miR-509-3-5p83.2564NM_001008660
PICALMhsa-miR-477583.2401NM_001206946
PICALMhsa-miR-590-3p82.9713NM_001206946
PICALMhsa-miR-155-5p82.7739NM_001206946
PICALMhsa-miR-318582.7656NM_001008660
PICALMhsa-miR-7159-5p82.2118NM_001008660
PICALMhsa-miR-93482.1659NM_001008660
PICALMhsa-miR-302f81.8545NM_001008660
PICALMhsa-miR-5197-3p81.5191NM_001008660
PICALMhsa-miR-155-3p81.327NM_001206946
PICALMhsa-miR-6838-3p81.2924NM_001008660
PICALMhsa-miR-5588-3p81.1225NM_001206946
PICALMhsa-miR-3162-5p81.1019NM_001008660
PICALMhsa-miR-6742-3p80.6866NM_001206946
PICALMhsa-miR-3173-3p80.164NM_001206946
PICALMhsa-miR-1211880.164NM_001206946
PICALMhsa-miR-200b-3p80.063NM_001206946
PICALMhsa-miR-200c-3p80.063NM_001206946
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Motifs and transcription factors (TFs) regulating PICALM

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
PICALMhdpi__TIMELESSTIMELESS (directAnnotation).
PICALMtaipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_reprGCM2; HES7 (directAnnotation).
PICALMmetacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PICALMjaspar__MA1122.1TFDP1 (directAnnotation).
PICALMtaipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_reprFIGLA; GCM1 (directAnnotation).
PICALMtaipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_reprETV5; TCF3 (directAnnotation).
PICALMtransfac_pro__M01253CNOT3 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."