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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHTF2

Summary for PHTF2

Gene information	Gene symbol	PHTF2
	Ensembl ID	ENSG00000006576
	Entrez ID	57157
	Gene name	putative homeodomain transcription factor 2
	Synonyms	DKFZp434D166
	Gene type	protein_coding
	UniProtAcc	Q8N3S3

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Dataset with differentially expressed gene: PHTF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.254583	2.80e-45
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.338465	1.55e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.39821	0.00e+00

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Expression of PHTF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHTF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHTF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHTF2	hsa-miR-548u	91.6459	NM_020432
PHTF2	hsa-miR-181c-5p	91.5998	NM_001127357
PHTF2	hsa-miR-181d-5p	91.5998	NM_001127357
PHTF2	hsa-miR-181b-5p	91.5998	NM_001127357
PHTF2	hsa-miR-181a-5p	91.5998	NM_001127357
PHTF2	hsa-miR-653-5p	91.5863	NM_001127359
PHTF2	hsa-miR-548c-3p	91.541	NM_001127357
PHTF2	hsa-miR-3148	91.4638	NM_001127359
PHTF2	hsa-miR-1277-5p	91.3266	NM_001127357
PHTF2	hsa-miR-6831-5p	91.0092	NM_001127359
PHTF2	hsa-miR-1297	90.3939	NM_001127357
PHTF2	hsa-miR-944	90.1063	NM_001127357
PHTF2	hsa-miR-5700	89.8716	NM_001127359
PHTF2	hsa-miR-9-3p	89.8686	NM_001127359
PHTF2	hsa-miR-3927-3p	89.7081	NM_001127359
PHTF2	hsa-miR-372-5p	89.7081	NM_001127357
PHTF2	hsa-miR-371a-5p	89.7081	NM_001127357
PHTF2	hsa-miR-4766-5p	89.4379	NM_001127357
PHTF2	hsa-miR-92b-3p	89.4143	NM_001127357
PHTF2	hsa-miR-92a-3p	89.4143	NM_001127357
PHTF2	hsa-miR-363-3p	89.4143	NM_001127357
PHTF2	hsa-miR-367-3p	89.4143	NM_001127357
PHTF2	hsa-miR-32-5p	89.4143	NM_001127357
PHTF2	hsa-miR-25-3p	89.4143	NM_001127357
PHTF2	hsa-miR-631	89.2381	NM_020432
PHTF2	hsa-miR-548n	89.2067	NM_001127357
PHTF2	hsa-miR-3661	88.1519	NM_020432
PHTF2	hsa-miR-3163	88.1132	NM_001127357
PHTF2	hsa-miR-1299	87.9341	NM_020432
PHTF2	hsa-miR-26a-5p	87.89	NM_001127357
PHTF2	hsa-miR-26b-5p	87.89	NM_001127357
PHTF2	hsa-miR-3613-3p	87.6523	NM_001127357
PHTF2	hsa-miR-380-3p	87.6364	NM_001127359
PHTF2	hsa-miR-4692	87.6345	NM_001127357
PHTF2	hsa-miR-5688	87.5163	NM_020432
PHTF2	hsa-miR-6830-5p	87.2627	NM_001127359
PHTF2	hsa-miR-5000-5p	87.035	NM_020432
PHTF2	hsa-miR-651-3p	86.8676	NM_001127359
PHTF2	hsa-miR-3714	86.805	NM_001127357
PHTF2	hsa-miR-3670	86.6782	NM_001127359
PHTF2	hsa-miR-802	86.6177	NM_001127357
PHTF2	hsa-miR-3978	86.2913	NM_020432
PHTF2	hsa-miR-875-3p	86.2075	NM_020432
PHTF2	hsa-miR-1303	85.972	NM_001127359
PHTF2	hsa-miR-1468-3p	85.8991	NM_001127357
PHTF2	hsa-miR-221-5p	85.7529	NM_001127357
PHTF2	hsa-miR-8073	85.7529	NM_001127357
PHTF2	hsa-miR-5008-3p	85.5533	NM_001127357
PHTF2	hsa-miR-6529-3p	85.5533	NM_001127357
PHTF2	hsa-miR-196a-1-3p	85.512	NM_001127359

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Motifs and transcription factors (TFs) regulating PHTF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHTF2	metacluster_7.13	ZFX (directAnnotation).
PHTF2	metacluster_151.2	ZNF23 (directAnnotation).
PHTF2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PHTF2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PHTF2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PHTF2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PHTF2	transfac_pro__M04826	EP300 (directAnnotation).
PHTF2	hdpi__NRL	NRL (directAnnotation).
PHTF2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PHTF2	cisbp__M00968	MTF2 (directAnnotation).
PHTF2	hdpi__FEZF2	FEZF2 (directAnnotation).
PHTF2	transfac_pro__M07310	SP5 (directAnnotation).
PHTF2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PHTF2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PHTF2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PHTF2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PHTF2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PHTF2	hdpi__HIP2	UBE2K (directAnnotation).
PHTF2	hdpi__ZNF304	ZNF304 (directAnnotation).
PHTF2	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
PHTF2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PHTF2	hocomoco__ZBT14_HUMAN.H11MO.0.C	ZBTB14 (directAnnotation).
PHTF2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
PHTF2	transfac_pro__M02089	E2F3 (directAnnotation).
PHTF2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PHTF2	transfac_pro__M03844	ELK4 (directAnnotation).
PHTF2	cisbp__M02645	ETS1 (directAnnotation).
PHTF2	metacluster_141.4	GLIS2 (directAnnotation).
PHTF2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PHTF2	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."