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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHF6

Summary for PHF6

Gene information	Gene symbol	PHF6
	Ensembl ID	ENSG00000156531
	Entrez ID	84295
	Gene name	PHD finger protein 6
	Synonyms	BFLS\|BORJ\|CENP-31\|KIAA1823\|MGC14797
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PHF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.277336	3.14e-16
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.279894	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.261426	4.09e-10

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Expression of PHF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHF6	hsa-miR-4465	87.532	NM_032458
PHF6	hsa-miR-9902	87.516	NM_001015877
PHF6	hsa-miR-512-5p	87.2808	NM_001015877
PHF6	hsa-miR-5587-5p	87.1158	NM_032458
PHF6	hsa-miR-6501-5p	87.0662	NM_001015877
PHF6	hsa-miR-548at-5p	86.6061	NM_001015877
PHF6	hsa-miR-224-5p	86.6006	NM_032458
PHF6	hsa-miR-4310	86.1896	NM_032458
PHF6	hsa-miR-3662	85.5823	NM_001015877
PHF6	hsa-miR-761	85.2475	NM_001015877
PHF6	hsa-miR-214-3p	85.2475	NM_001015877
PHF6	hsa-miR-582-5p	84.9419	NM_032458
PHF6	hsa-miR-6768-5p	84.9184	NM_001015877
PHF6	hsa-miR-498-5p	84.9129	NM_032458
PHF6	hsa-miR-4302	84.8435	NM_032458
PHF6	hsa-miR-3619-5p	84.5715	NM_001015877
PHF6	hsa-miR-548ar-3p	84.3402	NM_032458
PHF6	hsa-miR-885-5p	84.2909	NM_032458
PHF6	hsa-miR-4729	84.2719	NM_032458
PHF6	hsa-miR-3159	84.118	NM_032458
PHF6	hsa-miR-548f-3p	84.0059	NM_032458
PHF6	hsa-miR-548az-3p	84.0059	NM_032458
PHF6	hsa-miR-548e-3p	84.0059	NM_032458
PHF6	hsa-miR-548bc	84.0059	NM_032458
PHF6	hsa-miR-4477b	83.8174	NM_001015877
PHF6	hsa-miR-8069	83.6073	NM_001015877
PHF6	hsa-miR-6759-5p	83.538	NM_001015877
PHF6	hsa-miR-335-5p	83.4784	NM_001015877
PHF6	hsa-miR-4255	83.4315	NM_032458
PHF6	hsa-miR-7157-5p	83.2442	NM_032458
PHF6	hsa-miR-526b-5p	83.1973	NM_032458
PHF6	hsa-miR-1283	82.98	NM_032458
PHF6	hsa-miR-548a-3p	82.8188	NM_032458
PHF6	hsa-miR-8485	82.4565	NM_032458
PHF6	hsa-miR-548e-5p	81.9204	NM_032458
PHF6	hsa-miR-4325	81.847	NM_032458
PHF6	hsa-miR-3121-5p	81.8029	NM_032458
PHF6	hsa-miR-603	81.6791	NM_032458
PHF6	hsa-miR-5680	81.5542	NM_001015877
PHF6	hsa-miR-3613-3p	81.473	NM_001015877
PHF6	hsa-miR-3682-3p	81.2163	NM_032458
PHF6	hsa-miR-34a-3p	80.8301	NM_032458
PHF6	hsa-miR-518a-5p	80.7296	NM_001015877
PHF6	hsa-miR-527	80.7296	NM_001015877
PHF6	hsa-miR-1290	80.6967	NM_032458
PHF6	hsa-miR-12117	80.315	NM_001015877
PHF6	hsa-miR-3133	80.1737	NM_001015877
PHF6	hsa-miR-1323	80.1128	NM_032458
PHF6	hsa-miR-139-5p	80.0017	NM_032458

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Motifs and transcription factors (TFs) regulating PHF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHF6	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PHF6	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PHF6	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PHF6	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PHF6	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PHF6	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PHF6	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PHF6	transfac_pro__M04826	EP300 (directAnnotation).
PHF6	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PHF6	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PHF6	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PHF6	transfac_pro__M00652	NRF1 (directAnnotation).
PHF6	hdpi__ETV4	ETV4 (directAnnotation).
PHF6	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PHF6	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PHF6	hdpi__ELF2	ELF2 (directAnnotation).
PHF6	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PHF6	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
PHF6	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
PHF6	metacluster_183.4	ETS1 (inferredBy_Orthology).
PHF6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PHF6	transfac_pro__M02089	E2F3 (directAnnotation).
PHF6	transfac_pro__M02898	SMAD3 (directAnnotation).
PHF6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PHF6	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PHF6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PHF6	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PHF6	hdpi__HIP2	UBE2K (directAnnotation).
PHF6	hdpi__NRL	NRL (directAnnotation).
PHF6	transfac_pro__M00430	E2F1 (directAnnotation).
PHF6	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PHF6	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PHF6	transfac_pro__M07329	SP7 (directAnnotation).
PHF6	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
PHF6	transfac_pro__M07397	ZNF148 (directAnnotation).
PHF6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PHF6	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PHF6	cisbp__M07938	E2F1 (directAnnotation).
PHF6	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PHF6	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PHF6	transfac_pro__M07436	WT1 (directAnnotation).
PHF6	metacluster_3.14	WT1; WT1 (directAnnotation).
PHF6	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PHF6	transfac_pro__M01837	KLF11 (directAnnotation).
PHF6	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PHF6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PHF6	transfac_pro__M07310	SP5 (directAnnotation).
PHF6	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PHF6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PHF6	transfac_pro__M04817	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."