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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHF14

Summary for PHF14

Gene information	Gene symbol	PHF14
	Ensembl ID	ENSG00000106443
	Entrez ID	9678
	Gene name	PHD finger protein 14
	Synonyms	KIAA0783
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PHF14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.746816	4.43e-03
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.402785	1.75e-20
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.46469	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.443757	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.563238	2.59e-02
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.269718	3.40e-04
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.315126	0.00e+00

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Expression of PHF14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHF14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHF14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHF14	hsa-miR-302a-3p	84.9415	NM_014660
PHF14	hsa-miR-4762-3p	84.8954	NM_014660
PHF14	hsa-miR-4789-3p	84.183	NM_014660
PHF14	hsa-miR-4677-5p	84.1792	NM_014660
PHF14	hsa-miR-4742-3p	83.7611	NM_014660
PHF14	hsa-miR-8068	83.1483	NM_014660
PHF14	hsa-miR-335-3p	83.1451	NM_014660
PHF14	hsa-miR-4662b	82.9213	NM_014660
PHF14	hsa-miR-4647	82.9213	NM_014660
PHF14	hsa-miR-548c-3p	82.5595	NM_014660
PHF14	hsa-miR-520a-3p	82.3137	NM_014660
PHF14	hsa-miR-520b-3p	82.3137	NM_014660
PHF14	hsa-miR-520c-3p	82.3137	NM_014660
PHF14	hsa-miR-373-3p	82.3137	NM_014660
PHF14	hsa-miR-520e-3p	82.3137	NM_014660
PHF14	hsa-miR-372-3p	82.3137	NM_014660
PHF14	hsa-miR-520d-3p	82.3137	NM_014660
PHF14	hsa-miR-3613-3p	82.0038	NM_014660
PHF14	hsa-miR-153-5p	80.3896	NM_014660
PHF14	hsa-miR-513c-3p	80.2525	NM_014660
PHF14	hsa-miR-513a-3p	80.2525	NM_014660
PHF14	hsa-miR-4719	80.1493	NM_014660

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Motifs and transcription factors (TFs) regulating PHF14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHF14	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
PHF14	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PHF14	transfac_pro__M04617	ZBTB7A (directAnnotation).
PHF14	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PHF14	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PHF14	transfac_pro__M07387	ZBTB7A (directAnnotation).
PHF14	transfac_pro__M07436	WT1 (directAnnotation).
PHF14	transfac_pro__M00716	ZBTB14 (directAnnotation).
PHF14	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PHF14	hdpi__HIP2	UBE2K (directAnnotation).
PHF14	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PHF14	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PHF14	transfac_pro__M04893	TAF1 (directAnnotation).
PHF14	transfac_pro__M03876	ZBTB33 (directAnnotation).
PHF14	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PHF14	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PHF14	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PHF14	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PHF14	jaspar__MA1933.1	SREBF2 (directAnnotation).
PHF14	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PHF14	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PHF14	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PHF14	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PHF14	transfac_pro__M04826	EP300 (directAnnotation).
PHF14	hdpi__TP73	TP73 (directAnnotation).
PHF14	metacluster_55.5	ZNF541 (directAnnotation).
PHF14	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
PHF14	transfac_pro__M04950	EGR1 (directAnnotation).
PHF14	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
PHF14	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PHF14	jaspar__MA1935.1	FOXI1 (directAnnotation).
PHF14	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
PHF14	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PHF14	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PHF14	metacluster_183.4	ETS1 (inferredBy_Orthology).
PHF14	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PHF14	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
PHF14	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."