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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHC3

Summary for PHC3

Gene information	Gene symbol	PHC3
	Ensembl ID	ENSG00000173889
	Entrez ID	80012
	Gene name	polyhomeotic homolog 3
	Synonyms	EDR3\|FLJ12729\|FLJ12967\|HPH3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PHC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.29938	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.308893	0.00e+00

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Expression of PHC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHC3	hsa-miR-577	94.7858	NM_001308116
PHC3	hsa-miR-510-3p	94.7595	NM_001308116
PHC3	hsa-miR-3686	94.7011	NM_001308116
PHC3	hsa-miR-4801	94.5395	NM_001308116
PHC3	hsa-miR-6755-5p	94.3706	NM_001308116
PHC3	hsa-miR-218-5p	94.3564	NM_001308116
PHC3	hsa-miR-570-3p	94.2812	NM_001308116
PHC3	hsa-miR-1277-5p	94.007	NM_001308116
PHC3	hsa-miR-200a-3p	93.9574	NM_001308116
PHC3	hsa-miR-5010-3p	93.9121	NM_001308116
PHC3	hsa-miR-568	93.6725	NM_001308116
PHC3	hsa-miR-3613-3p	93.4621	NM_001308116
PHC3	hsa-miR-3646	93.3701	NM_001308116
PHC3	hsa-miR-7-1-3p	93.3253	NM_001308116
PHC3	hsa-miR-7-2-3p	93.3253	NM_001308116
PHC3	hsa-miR-495-3p	93.2206	NM_001308116
PHC3	hsa-miR-4731-3p	93.1697	NM_001308116
PHC3	hsa-miR-636	93.1359	NM_001308116
PHC3	hsa-miR-607	92.8357	NM_001308116
PHC3	hsa-miR-6128	92.0868	NM_001308116
PHC3	hsa-miR-5003-5p	91.3227	NM_001308116
PHC3	hsa-miR-1299	91.0458	NM_001308116
PHC3	hsa-miR-324-3p	91.0163	NM_001308116
PHC3	hsa-miR-4307	90.9438	NM_001308116
PHC3	hsa-miR-1323	90.5107	NM_001308116
PHC3	hsa-miR-548n	90.3795	NM_001308116
PHC3	hsa-miR-5009-3p	90.343	NM_001308116
PHC3	hsa-miR-513b-3p	89.7707	NM_001308116
PHC3	hsa-miR-519b-3p	89.767	NM_001308116
PHC3	hsa-miR-519a-3p	89.767	NM_001308116
PHC3	hsa-miR-519c-3p	89.767	NM_001308116
PHC3	hsa-miR-6882-5p	89.7228	NM_001308116
PHC3	hsa-miR-98-3p	89.6916	NM_001308116
PHC3	hsa-miR-488-3p	89.6529	NM_001308116
PHC3	hsa-miR-6503-3p	89.5164	NM_001308116
PHC3	hsa-miR-649	89.3129	NM_001308116
PHC3	hsa-miR-186-5p	89.2598	NM_001308116
PHC3	hsa-miR-4744	89.1556	NM_001308116
PHC3	hsa-miR-548o-3p	88.9651	NM_001308116
PHC3	hsa-miR-548an	88.5296	NM_001308116
PHC3	hsa-miR-4528	88.5138	NM_001308116
PHC3	hsa-miR-6768-3p	88.1982	NM_001308116
PHC3	hsa-miR-5580-3p	88.1235	NM_001308116
PHC3	hsa-miR-518c-5p	87.634	NM_001308116
PHC3	hsa-miR-3133	86.8136	NM_001308116
PHC3	hsa-miR-4426	86.7172	NM_001308116
PHC3	hsa-miR-320d	86.7031	NM_001308116
PHC3	hsa-miR-320b	86.7031	NM_001308116
PHC3	hsa-miR-320a-3p	86.7031	NM_001308116
PHC3	hsa-miR-4429	86.7031	NM_001308116

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Motifs and transcription factors (TFs) regulating PHC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHC3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PHC3	cisbp__M07938	E2F1 (directAnnotation).
PHC3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PHC3	jaspar__MA1650.1	ZBTB14 (directAnnotation).
PHC3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PHC3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PHC3	transfac_pro__M02090	E2F4 (directAnnotation).
PHC3	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PHC3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PHC3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PHC3	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
PHC3	jaspar__MA1122.1	TFDP1 (directAnnotation).
PHC3	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
PHC3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PHC3	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."