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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PGM2L1

Summary for PGM2L1

Gene information	Gene symbol	PGM2L1
	Ensembl ID	ENSG00000165434
	Entrez ID	283209
	Gene name	phosphoglucomutase 2 like 1
	Synonyms	BM32A\|FLJ32029
	Gene type	protein_coding
	UniProtAcc	Q6PCE3

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Dataset with differentially expressed gene: PGM2L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.545053	0.00e+00

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Expression of PGM2L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PGM2L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PGM2L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PGM2L1	hsa-miR-5696	88.0492	NM_173582
PGM2L1	hsa-miR-873-5p	87.7537	NM_173582
PGM2L1	hsa-miR-3201	87.6645	NM_173582
PGM2L1	hsa-miR-603	87.4874	NM_173582
PGM2L1	hsa-miR-519c-3p	86.9065	NM_173582
PGM2L1	hsa-miR-519a-3p	86.9065	NM_173582
PGM2L1	hsa-miR-519b-3p	86.9065	NM_173582
PGM2L1	hsa-miR-4282	86.6251	NM_173582
PGM2L1	hsa-miR-3671	86.5222	NM_173582
PGM2L1	hsa-miR-135b-3p	85.6395	NM_173582
PGM2L1	hsa-miR-135a-2-3p	85.6395	NM_173582
PGM2L1	hsa-miR-1250-3p	85.4763	NM_173582
PGM2L1	hsa-miR-607	85.357	NM_173582
PGM2L1	hsa-miR-3136-5p	83.5664	NM_173582
PGM2L1	hsa-miR-4439	83.5664	NM_173582
PGM2L1	hsa-miR-335-3p	83.2735	NM_173582
PGM2L1	hsa-miR-4698	83.1487	NM_173582
PGM2L1	hsa-miR-4500	82.8211	NM_173582
PGM2L1	hsa-miR-6504-3p	82.7509	NM_173582
PGM2L1	hsa-miR-6799-5p	82.6481	NM_173582
PGM2L1	hsa-miR-6875-5p	82.1919	NM_173582
PGM2L1	hsa-miR-3126-5p	82.1919	NM_173582
PGM2L1	hsa-miR-122b-5p	81.8015	NM_173582
PGM2L1	hsa-miR-3938	81.8015	NM_173582
PGM2L1	hsa-miR-410-3p	81.6548	NM_173582
PGM2L1	hsa-miR-3135a	81.4949	NM_173582
PGM2L1	hsa-miR-4251	81.2154	NM_173582
PGM2L1	hsa-miR-651-3p	80.7542	NM_173582
PGM2L1	hsa-miR-5688	80.6328	NM_173582
PGM2L1	hsa-miR-4719	80.4111	NM_173582
PGM2L1	hsa-miR-6873-3p	80.3483	NM_173582
PGM2L1	hsa-miR-6501-5p	80.2064	NM_173582
PGM2L1	hsa-miR-1245a	80.194	NM_173582
PGM2L1	hsa-miR-548aa	80.1199	NM_173582
PGM2L1	hsa-miR-548t-3p	80.1199	NM_173582
PGM2L1	hsa-miR-548ap-3p	80.1199	NM_173582

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Motifs and transcription factors (TFs) regulating PGM2L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PGM2L1	metacluster_135.11	NR2C2 (directAnnotation).
PGM2L1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PGM2L1	metacluster_198.3	ZFP64 (directAnnotation).
PGM2L1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PGM2L1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PGM2L1	metacluster_175.1	ZNF283 (directAnnotation).
PGM2L1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PGM2L1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PGM2L1	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."