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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PFN2

Summary for PFN2

Gene information	Gene symbol	PFN2
	Ensembl ID	ENSG00000070087
	Entrez ID	5217
	Gene name	profilin 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P35080

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Dataset with differentially expressed gene: PFN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.427339	9.81e-35
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.311685	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.15568	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.301287	3.26e-15
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.690883	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.888425	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.28273	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.374205	0.00e+00

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Expression of PFN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PFN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PFN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PFN2	hsa-miR-744-3p	83.6017	NM_053024
PFN2	hsa-miR-891b	83.4819	NM_002628
PFN2	hsa-miR-3617-3p	83.1923	NM_002628
PFN2	hsa-miR-487b-5p	82.532	NM_053024
PFN2	hsa-miR-487a-5p	82.532	NM_053024
PFN2	hsa-miR-527	81.9346	NM_053024
PFN2	hsa-miR-518a-5p	81.9346	NM_053024
PFN2	hsa-miR-139-5p	81.6032	NM_002628
PFN2	hsa-miR-4428	81.5332	NM_053024
PFN2	hsa-miR-371a-3p	81.2482	NM_053024
PFN2	hsa-miR-515-3p	81.2482	NM_053024
PFN2	hsa-miR-371b-3p	81.2482	NM_053024
PFN2	hsa-miR-33b-3p	81.2482	NM_053024
PFN2	hsa-miR-519e-3p	81.2482	NM_053024
PFN2	hsa-miR-1287-5p	80.9901	NM_053024
PFN2	hsa-miR-4803	80.9836	NM_053024
PFN2	hsa-miR-6715b-5p	80.868	NM_053024
PFN2	hsa-miR-4269	80.868	NM_053024
PFN2	hsa-miR-3160-5p	80.8445	NM_053024
PFN2	hsa-miR-4728-5p	80.4024	NM_053024
PFN2	hsa-miR-6785-5p	80.4024	NM_053024
PFN2	hsa-miR-19a-3p	80.0748	NM_053024
PFN2	hsa-miR-19b-3p	80.0748	NM_053024

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Motifs and transcription factors (TFs) regulating PFN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PFN2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PFN2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
PFN2	transfac_pro__M06140	ZNF250 (directAnnotation).
PFN2	jaspar__MA0748.2	YY2 (directAnnotation).
PFN2	transfac_pro__M02843	BBX (inferredBy_Orthology).
PFN2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PFN2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PFN2	transfac_pro__M04950	EGR1 (directAnnotation).
PFN2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PFN2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PFN2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PFN2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PFN2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PFN2	transfac_pro__M00652	NRF1 (directAnnotation).
PFN2	hdpi__ETV4	ETV4 (directAnnotation).
PFN2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PFN2	transfac_pro__M04866	HDAC2 (directAnnotation).
PFN2	jaspar__MA1122.1	TFDP1 (directAnnotation).
PFN2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PFN2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PFN2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PFN2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
PFN2	cisbp__M02645	ETS1 (directAnnotation).
PFN2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
PFN2	metacluster_135.11	NR2C2 (directAnnotation).
PFN2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PFN2	tfdimers__MD00038	TFAP2C (directAnnotation).
PFN2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PFN2	metacluster_7.13	ZFX (directAnnotation).
PFN2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PFN2	cisbp__M00968	MTF2 (directAnnotation).
PFN2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PFN2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PFN2	cisbp__M00341	PAX6 (directAnnotation).
PFN2	metacluster_198.3	ZFP64 (directAnnotation).
PFN2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PFN2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PFN2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PFN2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PFN2	cisbp__M00788	ZFY (inferredBy_Orthology).
PFN2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PFN2	metacluster_175.1	ZNF283 (directAnnotation).
PFN2	hdpi__ZNF304	ZNF304 (directAnnotation).
PFN2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PFN2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PFN2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PFN2	transfac_pro__M01199	TRIM28 (directAnnotation).
PFN2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PFN2	metacluster_151.2	ZNF23 (directAnnotation).
PFN2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PFN2	"Pentaglyme"	DB02580	small molecule
PFN2	"Triglyme"	DB02078	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."