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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PEX5L

Summary for PEX5L

Gene information	Gene symbol	PEX5L
	Ensembl ID	ENSG00000114757
	Entrez ID	51555
	Gene name	peroxisomal biogenesis factor 5 like
	Synonyms	PEX5R\|PXR2\|TRIP8b
	Gene type	protein_coding
	UniProtAcc	Q8IYB4

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Dataset with differentially expressed gene: PEX5L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.94652	1.43e-02
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.337562	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.354289	0.00e+00

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Expression of PEX5L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PEX5L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PEX5L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PEX5L	hsa-miR-3666	87.2957	NM_001256750
PEX5L	hsa-miR-301b-3p	87.2957	NM_001256750
PEX5L	hsa-miR-4295	87.2957	NM_001256750
PEX5L	hsa-miR-130a-3p	87.2957	NM_001256750
PEX5L	hsa-miR-130b-3p	87.2957	NM_001256750
PEX5L	hsa-miR-4282	87.0461	NM_001256750
PEX5L	hsa-miR-6778-3p	86.9539	NM_001256750
PEX5L	hsa-miR-4495	86.8361	NM_001256750
PEX5L	hsa-miR-576-5p	86.1042	NM_001256750
PEX5L	hsa-miR-8061	85.6391	NM_001256750
PEX5L	hsa-miR-300	85.3948	NM_001256750
PEX5L	hsa-miR-381-3p	85.3948	NM_001256750
PEX5L	hsa-miR-8066	85.2885	NM_001256750
PEX5L	hsa-miR-548aq-3p	85.1162	NM_001256750
PEX5L	hsa-miR-548ae-3p	85.1162	NM_001256750
PEX5L	hsa-miR-548ah-3p	85.1162	NM_001256750
PEX5L	hsa-miR-548am-3p	85.1162	NM_001256750
PEX5L	hsa-miR-548j-3p	85.1162	NM_001256750
PEX5L	hsa-miR-4776-3p	85.0072	NM_001256750
PEX5L	hsa-miR-548az-5p	84.9263	NM_001256750
PEX5L	hsa-miR-548aj-3p	84.8858	NM_001256750
PEX5L	hsa-miR-548x-3p	84.8858	NM_001256750
PEX5L	hsa-miR-5087	84.8405	NM_001256750
PEX5L	hsa-miR-4666a-3p	84.6938	NM_001256750
PEX5L	hsa-miR-8063	84.5244	NM_001256750
PEX5L	hsa-miR-126-5p	83.7455	NM_001256750
PEX5L	hsa-miR-2115-5p	83.5173	NM_001256750
PEX5L	hsa-miR-501-5p	82.9991	NM_001256750
PEX5L	hsa-miR-6888-3p	82.8294	NM_001256750
PEX5L	hsa-miR-4263	82.6712	NM_001256750
PEX5L	hsa-miR-510-3p	82.6686	NM_001256750
PEX5L	hsa-miR-4795-3p	81.7645	NM_001256750
PEX5L	hsa-miR-6809-3p	81.692	NM_001256750
PEX5L	hsa-miR-5010-3p	81.5306	NM_001256750
PEX5L	hsa-miR-4708-3p	81.3765	NM_001256750
PEX5L	hsa-miR-590-3p	81.1298	NM_001256750
PEX5L	hsa-let-7f-1-3p	81.032	NM_001256750
PEX5L	hsa-miR-98-3p	81.032	NM_001256750
PEX5L	hsa-let-7b-3p	81.032	NM_001256750
PEX5L	hsa-miR-203a-3p	80.21	NM_001256750
PEX5L	hsa-miR-548t-5p	80.1694	NM_001256750
PEX5L	hsa-miR-570-3p	80.0753	NM_001256750

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Motifs and transcription factors (TFs) regulating PEX5L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PEX5L	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PEX5L	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PEX5L	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
PEX5L	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PEX5L	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PEX5L	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
PEX5L	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PEX5L	metacluster_3.14	WT1; WT1 (directAnnotation).
PEX5L	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PEX5L	cisbp__M07938	E2F1 (directAnnotation).
PEX5L	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PEX5L	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PEX5L	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PEX5L	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
PEX5L	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PEX5L	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PEX5L	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PEX5L	metacluster_7.13	ZFX (directAnnotation).
PEX5L	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PEX5L	transfac_pro__M01175	ZBTB7B (directAnnotation).
PEX5L	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PEX5L	tfdimers__MD00151	CHURC1 (directAnnotation).
PEX5L	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PEX5L	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PEX5L	transfac_pro__M01303	SP1 (directAnnotation).
PEX5L	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PEX5L	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PEX5L	transfac_pro__M02090	E2F4 (directAnnotation).
PEX5L	transfac_pro__M01714	KLF15 (directAnnotation).
PEX5L	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PEX5L	jaspar__MA1122.1	TFDP1 (directAnnotation).
PEX5L	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PEX5L	transfac_pro__M02089	E2F3 (directAnnotation).
PEX5L	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
PEX5L	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PEX5L	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PEX5L	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PEX5L	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PEX5L	transfac_pro__M07436	WT1 (directAnnotation).
PEX5L	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PEX5L	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PEX5L	transfac_pro__M02898	SMAD3 (directAnnotation).
PEX5L	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PEX5L	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."