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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PEG10

Summary for PEG10

Gene information	Gene symbol	PEG10
	Ensembl ID	ENSG00000242265
	Entrez ID	23089
	Gene name	paternally expressed 10
	Synonyms	HB-1\|KIAA1051\|Mar2\|Mart2\|MEF3L\|RGAG3\|RTL2\|SIRH1
	Gene type	protein_coding
	UniProtAcc	Q86TG7

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Dataset with differentially expressed gene: PEG10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.1309	6.74e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.315317	5.32e-04
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.267946	1.77e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.99893	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	1.33343	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	1.22538	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.803441	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.44402	1.68e-21
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	2.22297	0.00e+00

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Expression of PEG10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PEG10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PEG10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PEG10	hsa-miR-3144-5p	85.2186	NM_001040152
PEG10	hsa-miR-1323	85.1272	NM_015068
PEG10	hsa-miR-4687-5p	84.9458	NM_001040152
PEG10	hsa-miR-548e-5p	84.8363	NM_015068
PEG10	hsa-miR-548o-3p	84.679	NM_015068
PEG10	hsa-miR-6758-5p	84.5565	NM_015068
PEG10	hsa-miR-6856-5p	83.9396	NM_015068
PEG10	hsa-miR-182-5p	83.2832	NM_001040152
PEG10	hsa-miR-944	83.0693	NM_015068
PEG10	hsa-miR-500b-5p	83.0317	NM_001040152
PEG10	hsa-miR-362-5p	83.0317	NM_001040152
PEG10	hsa-miR-202-3p	82.7601	NM_001040152
PEG10	hsa-let-7d-5p	82.7601	NM_001040152
PEG10	hsa-miR-4458	82.7601	NM_001040152
PEG10	hsa-miR-450b-3p	82.7491	NM_001184962
PEG10	hsa-miR-4457	82.5874	NM_001040152
PEG10	hsa-miR-3148	82.2278	NM_015068
PEG10	hsa-miR-6514-5p	81.9732	NM_015068
PEG10	hsa-miR-885-3p	81.5116	NM_001040152
PEG10	hsa-miR-34a-5p	81.1199	NM_001040152
PEG10	hsa-miR-449a	81.1199	NM_001040152
PEG10	hsa-miR-4282	80.7535	NM_001184962
PEG10	hsa-miR-6776-5p	80.7213	NM_001040152
PEG10	hsa-miR-1470	80.63	NM_001040152
PEG10	hsa-miR-3649	80.4819	NM_001040152
PEG10	hsa-miR-3616-3p	80.3167	NM_001040152
PEG10	hsa-miR-4452	80.0316	NM_015068

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Motifs and transcription factors (TFs) regulating PEG10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PEG10	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PEG10	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PEG10	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PEG10	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PEG10	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PEG10	transfac_pro__M00652	NRF1 (directAnnotation).
PEG10	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PEG10	hdpi__TP73	TP73 (directAnnotation).
PEG10	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
PEG10	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PEG10	jaspar__MA0748.2	YY2 (directAnnotation).
PEG10	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
PEG10	metacluster_182.10	ZFX (directAnnotation).
PEG10	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
PEG10	transfac_pro__M09726	GATAD2A (directAnnotation).
PEG10	tfdimers__MD00516	SOX10 (directAnnotation).
PEG10	metacluster_110.2	ZNF549 (directAnnotation).
PEG10	metacluster_150.9	VSX2; VSX2 (directAnnotation).
PEG10	jaspar__MA0079.5	SP1 (directAnnotation).
PEG10	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
PEG10	transfac_pro__M04817	ZBTB33 (directAnnotation).
PEG10	cisbp__M07938	E2F1 (directAnnotation).
PEG10	transfac_pro__M06063	ZNF99 (directAnnotation).
PEG10	metacluster_178.3	NKX1-1; NKX1-2 (directAnnotation). GSX1; HOXB2; HOXB3 (inferredBy_Orthology).
PEG10	cisbp__M01725	SREBF2 (inferredBy_Orthology).
PEG10	transfac_pro__M05956	BCL11B (directAnnotation).
PEG10	kznf__ZNF550_Imbeault2017_OM_RCADE	ZNF550 (directAnnotation).
PEG10	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PEG10	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PEG10	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
PEG10	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
PEG10	cisbp__M00808	MYPOP (inferredBy_Orthology).
PEG10	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."