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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDS5A

Summary for PDS5A

Gene information	Gene symbol	PDS5A
	Ensembl ID	ENSG00000121892
	Entrez ID	23244
	Gene name	PDS5 cohesin associated factor A
	Synonyms	KIAA0648\|PIG54\|SCC-112
	Gene type	protein_coding
	UniProtAcc	Q29RF7

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Dataset with differentially expressed gene: PDS5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.397511	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.3148	5.96e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.346456	0.00e+00

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Expression of PDS5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDS5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDS5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDS5A	hsa-miR-302d-5p	91.298	NM_001100399
PDS5A	hsa-miR-302b-5p	91.298	NM_001100399
PDS5A	hsa-miR-4697-3p	91.1476	NM_001100399
PDS5A	hsa-miR-491-3p	91.1473	NM_001100399
PDS5A	hsa-miR-4793-3p	90.7543	NM_001100399
PDS5A	hsa-miR-3612	90.726	NM_001100399
PDS5A	hsa-miR-650	90.726	NM_001100399
PDS5A	hsa-miR-298	90.6364	NM_001100399
PDS5A	hsa-miR-5571-5p	90.0878	NM_001100399
PDS5A	hsa-miR-211-3p	89.6015	NM_001100399
PDS5A	hsa-miR-3941	89.5625	NM_001100399
PDS5A	hsa-miR-129-5p	89.3335	NM_001100399
PDS5A	hsa-miR-9983-3p	89.3335	NM_001100399
PDS5A	hsa-miR-4790-3p	88.9666	NM_001100400
PDS5A	hsa-miR-1468-3p	88.1624	NM_001100399
PDS5A	hsa-miR-5003-3p	88.1495	NM_001100399
PDS5A	hsa-miR-152-5p	88.1437	NM_001100399
PDS5A	hsa-miR-4718	88.0655	NM_001100399
PDS5A	hsa-miR-508-5p	87.8086	NM_001100399
PDS5A	hsa-miR-4652-3p	87.3676	NM_001100399
PDS5A	hsa-miR-149-5p	87.2736	NM_001100399
PDS5A	hsa-miR-302c-5p	87.0483	NM_001100399
PDS5A	hsa-miR-103a-3p	87.0024	NM_001100399
PDS5A	hsa-miR-107	87.0024	NM_001100399
PDS5A	hsa-miR-934	86.5297	NM_001100400
PDS5A	hsa-miR-510-3p	86.4718	NM_001100399
PDS5A	hsa-miR-3121-3p	85.9286	NM_001100400
PDS5A	hsa-miR-513a-5p	85.6117	NM_001100399
PDS5A	hsa-miR-1290	85.4845	NM_001100399
PDS5A	hsa-miR-143-5p	85.1674	NM_001100399
PDS5A	hsa-miR-222-5p	85.0642	NM_001100399
PDS5A	hsa-miR-3714	85.0425	NM_001100399
PDS5A	hsa-miR-5192	84.2086	NM_001100399
PDS5A	hsa-miR-6828-3p	83.9643	NM_001100399
PDS5A	hsa-miR-466	83.7789	NM_001100399
PDS5A	hsa-miR-3145-5p	83.6765	NM_001100400
PDS5A	hsa-miR-4302	83.5921	NM_001100399
PDS5A	hsa-miR-6888-5p	83.5697	NM_001100399
PDS5A	hsa-miR-5589-3p	83.3554	NM_001100400
PDS5A	hsa-miR-3191-5p	83.3414	NM_001100399
PDS5A	hsa-miR-22-3p	83.3409	NM_001100399
PDS5A	hsa-miR-494-3p	83.33	NM_001100399
PDS5A	hsa-miR-561-5p	83.1124	NM_001100399
PDS5A	hsa-miR-576-5p	82.9255	NM_001100400
PDS5A	hsa-miR-3973	82.7086	NM_001100400
PDS5A	hsa-miR-6875-5p	82.6521	NM_001100399
PDS5A	hsa-miR-3126-5p	82.6521	NM_001100399
PDS5A	hsa-miR-943	81.9106	NM_001100399
PDS5A	hsa-miR-4789-5p	81.7789	NM_001100399
PDS5A	hsa-miR-1184	81.5131	NM_001100399

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Motifs and transcription factors (TFs) regulating PDS5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDS5A	metacluster_7.13	ZFX (directAnnotation).
PDS5A	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PDS5A	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
PDS5A	metacluster_151.2	ZNF23 (directAnnotation).
PDS5A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PDS5A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PDS5A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PDS5A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PDS5A	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PDS5A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PDS5A	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PDS5A	transfac_pro__M04950	EGR1 (directAnnotation).
PDS5A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PDS5A	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
PDS5A	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PDS5A	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PDS5A	cisbp__M08198	ELF1 (directAnnotation).
PDS5A	transfac_pro__M00652	NRF1 (directAnnotation).
PDS5A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PDS5A	transfac_pro__M04866	HDAC2 (directAnnotation).
PDS5A	jaspar__MA1122.1	TFDP1 (directAnnotation).
PDS5A	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PDS5A	hdpi__ETV4	ETV4 (directAnnotation).
PDS5A	hdpi__TP73	TP73 (directAnnotation).
PDS5A	hdpi__ELF2	ELF2 (directAnnotation).
PDS5A	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."