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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCGF5

Summary for PCGF5

Gene information	Gene symbol	PCGF5
	Ensembl ID	ENSG00000180628
	Entrez ID	84333
	Gene name	polycomb group ring finger 5
	Synonyms	MGC16202\|RNF159
	Gene type	protein_coding
	UniProtAcc	Q86SE9

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Dataset with differentially expressed gene: PCGF5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.49394	9.24e-21
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.367997	2.85e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.583432	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.329468	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.279159	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.392217	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.411546	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.310265	0.00e+00

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Expression of PCGF5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCGF5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCGF5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCGF5	hsa-miR-545-5p	87.7249	NM_001256549
PCGF5	hsa-miR-548g-5p	87.5831	NM_001256549
PCGF5	hsa-miR-548x-5p	87.5831	NM_001256549
PCGF5	hsa-miR-548aj-5p	87.5831	NM_001256549
PCGF5	hsa-miR-548f-5p	86.3048	NM_001256549
PCGF5	hsa-miR-548p	86.1562	NM_001256549
PCGF5	hsa-let-7c-3p	85.9555	NM_001256549
PCGF5	hsa-miR-4504	85.8255	NM_001256549
PCGF5	hsa-miR-10527-5p	85.6421	NM_001256549
PCGF5	hsa-miR-320d	85.4076	NM_001256549
PCGF5	hsa-miR-320b	85.4076	NM_001256549
PCGF5	hsa-miR-320a-3p	85.4076	NM_001256549
PCGF5	hsa-miR-320c	85.4076	NM_001256549
PCGF5	hsa-miR-664a-3p	85.3519	NM_001256549
PCGF5	hsa-miR-4328	84.7271	NM_001256549
PCGF5	hsa-miR-6772-3p	84.5215	NM_001256549
PCGF5	hsa-miR-361-5p	84.0058	NM_001256549
PCGF5	hsa-miR-4799-5p	83.9221	NM_001256549
PCGF5	hsa-miR-4297	83.7016	NM_001256549
PCGF5	hsa-miR-6807-5p	83.6127	NM_001256549
PCGF5	hsa-miR-196a-1-3p	83.447	NM_001256549
PCGF5	hsa-miR-892c-5p	83.432	NM_001256549
PCGF5	hsa-miR-4263	83.1245	NM_001256549
PCGF5	hsa-miR-137-3p	83.0874	NM_001256549
PCGF5	hsa-miR-6507-5p	82.776	NM_001256549
PCGF5	hsa-miR-6814-5p	82.6804	NM_001256549
PCGF5	hsa-miR-6888-5p	82.5962	NM_001256549
PCGF5	hsa-miR-7978	82.5817	NM_001256549
PCGF5	hsa-miR-154-5p	82.5527	NM_001256549
PCGF5	hsa-miR-4426	82.4659	NM_001256549
PCGF5	hsa-miR-1277-5p	82.4538	NM_001256549
PCGF5	hsa-miR-3133	82.403	NM_001256549
PCGF5	hsa-miR-9902	82.1556	NM_001256549
PCGF5	hsa-miR-4429	82.1271	NM_001256549
PCGF5	hsa-miR-3618	82.1247	NM_001256549
PCGF5	hsa-miR-145-3p	81.9902	NM_001256549
PCGF5	hsa-miR-548av-3p	81.8519	NM_001256549
PCGF5	hsa-miR-498-5p	81.4543	NM_001256549
PCGF5	hsa-miR-374a-5p	81.354	NM_001256549
PCGF5	hsa-miR-222-5p	81.2867	NM_001256549
PCGF5	hsa-miR-548c-3p	80.7783	NM_001256549

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Motifs and transcription factors (TFs) regulating PCGF5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCGF5	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PCGF5	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PCGF5	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
PCGF5	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PCGF5	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PCGF5	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PCGF5	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
PCGF5	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PCGF5	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PCGF5	metacluster_3.14	WT1; WT1 (directAnnotation).
PCGF5	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PCGF5	cisbp__M07938	E2F1 (directAnnotation).
PCGF5	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PCGF5	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PCGF5	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PCGF5	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PCGF5	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PCGF5	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PCGF5	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PCGF5	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PCGF5	transfac_pro__M00652	NRF1 (directAnnotation).
PCGF5	hdpi__ETV4	ETV4 (directAnnotation).
PCGF5	transfac_pro__M04866	HDAC2 (directAnnotation).
PCGF5	jaspar__MA1122.1	TFDP1 (directAnnotation).
PCGF5	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PCGF5	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PCGF5	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PCGF5	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
PCGF5	metacluster_3.10	KLF2; KLF4 (directAnnotation).
PCGF5	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PCGF5	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
PCGF5	transfac_pro__M01783	SP2 (directAnnotation).
PCGF5	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PCGF5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PCGF5	cisbp__M00341	PAX6 (directAnnotation).
PCGF5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PCGF5	transfac_pro__M01253	CNOT3 (directAnnotation).
PCGF5	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PCGF5	metacluster_7.13	ZFX (directAnnotation).
PCGF5	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
PCGF5	cisbp__M00968	MTF2 (directAnnotation).
PCGF5	transfac_pro__M04817	ZBTB33 (directAnnotation).
PCGF5	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PCGF5	transfac_pro__M02089	E2F3 (directAnnotation).
PCGF5	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PCGF5	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PCGF5	transfac_pro__M01298	MECP2 (directAnnotation).
PCGF5	transfac_pro__M05798	ZNF517 (directAnnotation).
PCGF5	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
PCGF5	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."