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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCDH17

Summary for PCDH17

Gene information	Gene symbol	PCDH17
	Ensembl ID	ENSG00000118946
	Entrez ID	27253
	Gene name	protocadherin 17
	Synonyms	PCDH68\|PCH68
	Gene type	protein_coding
	UniProtAcc	O14917

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Dataset with differentially expressed gene: PCDH17

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.779542	0.00e+00

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Expression of PCDH17 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCDH17

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCDH17

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCDH17	hsa-let-7f-2-3p	90.5002	NM_001040429
PCDH17	hsa-miR-3149	90.4127	NM_001040429
PCDH17	hsa-miR-1200	90.3724	NM_001040429
PCDH17	hsa-miR-4772-3p	90.181	NM_001040429
PCDH17	hsa-miR-550a-3p	90.0918	NM_001040429
PCDH17	hsa-miR-130a-5p	90.0909	NM_001040429
PCDH17	hsa-miR-374c-3p	89.7128	NM_001040429
PCDH17	hsa-miR-1250-3p	89.3472	NM_001040429
PCDH17	hsa-miR-936	88.4942	NM_001040429
PCDH17	hsa-miR-133b	88.4334	NM_001040429
PCDH17	hsa-miR-133a-3p	88.4334	NM_001040429
PCDH17	hsa-miR-4436a	88.3405	NM_001040429
PCDH17	hsa-miR-34b-3p	87.9987	NM_001040429
PCDH17	hsa-miR-4307	87.8463	NM_001040429
PCDH17	hsa-miR-200c-5p	87.6442	NM_001040429
PCDH17	hsa-miR-4265	87.4928	NM_001040429
PCDH17	hsa-miR-4322	87.4928	NM_001040429
PCDH17	hsa-miR-153-5p	87.4921	NM_001040429
PCDH17	hsa-miR-4520-3p	87.2175	NM_001040429
PCDH17	hsa-miR-4502	87.0053	NM_001040429
PCDH17	hsa-miR-569	86.7927	NM_001040429
PCDH17	hsa-miR-221-5p	86.3783	NM_001040429
PCDH17	hsa-miR-8073	86.3783	NM_001040429
PCDH17	hsa-miR-3140-3p	86.0582	NM_001040429
PCDH17	hsa-miR-3163	85.8458	NM_001040429
PCDH17	hsa-miR-122b-5p	85.8034	NM_001040429
PCDH17	hsa-miR-4457	85.773	NM_001040429
PCDH17	hsa-miR-146a-3p	85.6715	NM_001040429
PCDH17	hsa-miR-561-3p	85.1141	NM_001040429
PCDH17	hsa-miR-190b-3p	84.9014	NM_001040429
PCDH17	hsa-miR-12129	84.5128	NM_001040429
PCDH17	hsa-miR-5690	84.2775	NM_001040429
PCDH17	hsa-miR-548an	83.7412	NM_001040429
PCDH17	hsa-miR-9983-3p	83.1923	NM_001040429
PCDH17	hsa-miR-670-3p	83.0715	NM_001040429
PCDH17	hsa-miR-4799-5p	82.9831	NM_001040429
PCDH17	hsa-miR-335-3p	82.6046	NM_001040429
PCDH17	hsa-miR-4520-2-3p	82.517	NM_001040429
PCDH17	hsa-miR-339-5p	82.2819	NM_001040429
PCDH17	hsa-miR-130b-5p	82.181	NM_001040429
PCDH17	hsa-miR-5196-3p	81.9844	NM_001040429
PCDH17	hsa-miR-4743-3p	81.8499	NM_001040429
PCDH17	hsa-miR-676-3p	81.7711	NM_001040429
PCDH17	hsa-miR-6734-5p	81.4991	NM_001040429
PCDH17	hsa-miR-576-5p	81.4626	NM_001040429
PCDH17	hsa-miR-5587-5p	81.028	NM_001040429
PCDH17	hsa-miR-129-5p	80.5803	NM_001040429
PCDH17	hsa-miR-654-3p	80.4722	NM_001040429
PCDH17	hsa-miR-6737-3p	80.4594	NM_001040429
PCDH17	hsa-miR-7157-3p	80.4594	NM_001040429

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Motifs and transcription factors (TFs) regulating PCDH17

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCDH17	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PCDH17	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PCDH17	jaspar__MA0502.2	NFYB (directAnnotation).
PCDH17	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PCDH17	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PCDH17	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PCDH17	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PCDH17	cisbp__M00249	WT1 (directAnnotation).
PCDH17	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PCDH17	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PCDH17	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PCDH17	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."