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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAXBP1

Summary for PAXBP1

Gene information	Gene symbol	PAXBP1
	Ensembl ID	ENSG00000263141
	Entrez ID	94104
	Gene name	PAX3 and PAX7 binding protein 1
	Synonyms	C21orf66\|fSAP105\|GCFC\|GCFC1
	Gene type	protein_coding
	UniProtAcc	Q9Y5B6

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Dataset with differentially expressed gene: PAXBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.295078	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.25009	8.54e-35
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.427596	0.00e+00

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Expression of PAXBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAXBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAXBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAXBP1	hsa-miR-6793-5p	87.4052	NM_016631
PAXBP1	hsa-miR-3658	87.0646	NM_016631
PAXBP1	hsa-miR-367-3p	87.0195	NM_016631
PAXBP1	hsa-miR-363-3p	87.0195	NM_016631
PAXBP1	hsa-miR-25-3p	87.0195	NM_016631
PAXBP1	hsa-miR-11181-3p	86.3094	NM_013329
PAXBP1	hsa-miR-5089-5p	85.4356	NM_016631
PAXBP1	hsa-miR-6816-3p	85.1335	NM_016631
PAXBP1	hsa-miR-4775	84.8602	NM_016631
PAXBP1	hsa-miR-4638-3p	84.7408	NM_013329
PAXBP1	hsa-miR-3194-5p	84.3932	NM_016631
PAXBP1	hsa-miR-1179	83.1205	NM_016631
PAXBP1	hsa-miR-4328	82.6114	NM_013329
PAXBP1	hsa-miR-561-5p	82.5893	NM_016631
PAXBP1	hsa-miR-4768-3p	81.6346	NM_013329
PAXBP1	hsa-miR-510-3p	81.2666	NM_016631
PAXBP1	hsa-miR-379-3p	81.0767	NM_013329
PAXBP1	hsa-miR-411-3p	81.0767	NM_013329
PAXBP1	hsa-miR-34a-3p	81.0638	NM_016631
PAXBP1	hsa-miR-190a-3p	80.4226	NM_016631

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Motifs and transcription factors (TFs) regulating PAXBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAXBP1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PAXBP1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PAXBP1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PAXBP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PAXBP1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PAXBP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PAXBP1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PAXBP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."