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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PARP8

Summary for PARP8

Gene information	Gene symbol	PARP8
	Ensembl ID	ENSG00000151883
	Entrez ID	79668
	Gene name	poly(ADP-ribose) polymerase family member 8
	Synonyms	ARTD16\|FLJ21308\|pART16
	Gene type	protein_coding
	UniProtAcc	Q8N3A8

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Dataset with differentially expressed gene: PARP8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.39924	1.91e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.289297	8.41e-45
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.267199	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.370755	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.305101	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.269712	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.310321	0.00e+00

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Expression of PARP8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PARP8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PARP8	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PARP8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PARP8	hsa-miR-6884-5p	82.9534	NM_001178055
PARP8	hsa-miR-485-5p	82.9534	NM_001178055
PARP8	hsa-miR-4500	82.6729	NM_001178055
PARP8	hsa-miR-4267	82.5129	NM_001178055
PARP8	hsa-miR-302a-3p	82.3829	NM_001178055
PARP8	hsa-miR-302b-3p	82.3829	NM_001178055
PARP8	hsa-miR-302c-3p	82.3829	NM_001178055
PARP8	hsa-miR-302d-3p	82.3829	NM_001178055
PARP8	hsa-miR-374b-3p	82.3072	NM_001178055
PARP8	hsa-miR-1287-5p	82.1087	NM_001178055
PARP8	hsa-miR-372-3p	81.483	NM_001178055
PARP8	hsa-miR-520b-3p	81.483	NM_001178055
PARP8	hsa-miR-520a-3p	81.483	NM_001178055
PARP8	hsa-miR-520c-3p	81.483	NM_001178055
PARP8	hsa-miR-520d-3p	81.483	NM_001178055
PARP8	hsa-miR-520e-3p	81.483	NM_001178055
PARP8	hsa-miR-373-3p	81.483	NM_001178055
PARP8	hsa-miR-891a-3p	81.0461	NM_001178055
PARP8	hsa-let-7c-5p	80.3828	NM_001178055
PARP8	hsa-let-7a-5p	80.3828	NM_001178055
PARP8	hsa-let-7f-5p	80.3828	NM_001178055
PARP8	hsa-miR-98-5p	80.3828	NM_001178055
PARP8	hsa-let-7e-5p	80.3828	NM_001178055
PARP8	hsa-let-7i-5p	80.3828	NM_001178055
PARP8	hsa-let-7g-5p	80.3828	NM_001178055
PARP8	hsa-let-7b-5p	80.3828	NM_001178055
PARP8	hsa-miR-3617-3p	80.035	NM_001178055

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Motifs and transcription factors (TFs) regulating PARP8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PARP8	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
PARP8	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PARP8	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PARP8	transfac_pro__M04617	ZBTB7A (directAnnotation).
PARP8	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PARP8	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
PARP8	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PARP8	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PARP8	transfac_pro__M07387	ZBTB7A (directAnnotation).
PARP8	transfac_pro__M07436	WT1 (directAnnotation).
PARP8	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PARP8	transfac_pro__M00716	ZBTB14 (directAnnotation).
PARP8	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PARP8	hdpi__HIP2	UBE2K (directAnnotation).
PARP8	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PARP8	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PARP8	transfac_pro__M04893	TAF1 (directAnnotation).
PARP8	transfac_pro__M03876	ZBTB33 (directAnnotation).
PARP8	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PARP8	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PARP8	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PARP8	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PARP8	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PARP8	metacluster_119.1	ZNF677 (directAnnotation).
PARP8	transfac_pro__M08187	ABL1 (directAnnotation).
PARP8	transfac_pro__M05894	ZNF565 (directAnnotation).
PARP8	homer__NNTGTTTATTTTGGCA_NF1_FOXA1	FOXA1; NF1 (directAnnotation).
PARP8	transfac_pro__M05794	ZNF621 (directAnnotation).
PARP8	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
PARP8	taipale_tf_pairs__FOXA1_TRNGTAAACA_HT	FOXA1 (directAnnotation).
PARP8	transfac_pro__M05626	ZNF780A (directAnnotation).
PARP8	tfdimers__MD00061	E2F1; NR3C1 (directAnnotation).
PARP8	transfac_pro__M06366	ZNF530 (directAnnotation).
PARP8	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
PARP8	transfac_pro__M06370	ZNF585A (directAnnotation).
PARP8	tfdimers__MD00299	ETS1; SRY (directAnnotation).
PARP8	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
PARP8	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
PARP8	transfac_pro__M06499	ZNF383 (directAnnotation).
PARP8	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
PARP8	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PARP8	hdpi__NRL	NRL (directAnnotation).
PARP8	transfac_pro__M07310	SP5 (directAnnotation).
PARP8	cisbp__M07938	E2F1 (directAnnotation).
PARP8	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
PARP8	cisbp__M00968	MTF2 (directAnnotation).
PARP8	transfac_pro__M04817	ZBTB33 (directAnnotation).
PARP8	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PARP8	tfdimers__MD00483	ZBTB14 (directAnnotation).
PARP8	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."