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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAG1

Summary for PAG1

Gene information	Gene symbol	PAG1
	Ensembl ID	ENSG00000076641
	Entrez ID	55824
	Gene name	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
	Synonyms	CBP\|PAG
	Gene type	protein_coding
	UniProtAcc	Q9NWQ8

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Dataset with differentially expressed gene: PAG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.419033	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.390692	1.25e-11
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.365478	2.00e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.377458	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.263282	2.28e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.391723	0.00e+00

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Expression of PAG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAG1	hsa-miR-3133	85.6291	NM_018440
PAG1	hsa-miR-6724-5p	85.5342	NM_018440
PAG1	hsa-miR-3074-5p	84.9302	NM_018440
PAG1	hsa-miR-4753-3p	84.8473	NM_018440
PAG1	hsa-miR-3919	84.3625	NM_018440
PAG1	hsa-miR-4782-5p	84.1197	NM_018440
PAG1	hsa-miR-5706	84.1197	NM_018440
PAG1	hsa-miR-8067	84.0655	NM_018440
PAG1	hsa-miR-4649-3p	83.607	NM_018440
PAG1	hsa-miR-580-3p	83.5372	NM_018440
PAG1	hsa-miR-3646	83.2826	NM_018440
PAG1	hsa-miR-4433b-5p	83.1528	NM_018440
PAG1	hsa-miR-2117	82.9019	NM_018440
PAG1	hsa-miR-205-3p	82.8516	NM_018440
PAG1	hsa-miR-20b-5p	82.5793	NM_018440
PAG1	hsa-miR-17-5p	82.5793	NM_018440
PAG1	hsa-miR-93-5p	82.5793	NM_018440
PAG1	hsa-miR-519d-3p	82.5793	NM_018440
PAG1	hsa-miR-4311	82.5737	NM_018440
PAG1	hsa-miR-1236-3p	82.4803	NM_018440
PAG1	hsa-miR-106b-5p	82.4744	NM_018440
PAG1	hsa-miR-20a-5p	82.4744	NM_018440
PAG1	hsa-miR-106a-5p	82.4744	NM_018440
PAG1	hsa-miR-4503	82.4729	NM_018440
PAG1	hsa-miR-6893-3p	82.1083	NM_018440
PAG1	hsa-miR-548az-5p	82.0328	NM_018440
PAG1	hsa-miR-548t-5p	82.0328	NM_018440
PAG1	hsa-miR-619-5p	81.4703	NM_018440
PAG1	hsa-miR-26a-5p	81.4024	NM_018440
PAG1	hsa-miR-26b-5p	81.4024	NM_018440
PAG1	hsa-miR-4775	81.3359	NM_018440
PAG1	hsa-miR-1-5p	81.261	NM_018440
PAG1	hsa-miR-4422	80.6061	NM_018440
PAG1	hsa-miR-12136	80.4166	NM_018440
PAG1	hsa-miR-548d-3p	80.331	NM_018440
PAG1	hsa-miR-3123	80.3036	NM_018440
PAG1	hsa-miR-1183	80.1697	NM_018440
PAG1	hsa-miR-8063	80.1618	NM_018440
PAG1	hsa-miR-370-3p	80.1232	NM_018440

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Motifs and transcription factors (TFs) regulating PAG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAG1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
PAG1	metacluster_151.2	ZNF23 (directAnnotation).
PAG1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PAG1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PAG1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PAG1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PAG1	transfac_pro__M06857	ZNF611 (directAnnotation).
PAG1	transfac_pro__M06833	PEG3 (directAnnotation).
PAG1	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
PAG1	transfac_pro__M01253	CNOT3 (directAnnotation).
PAG1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PAG1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PAG1	transfac_pro__M05712	ZNF134 (directAnnotation).
PAG1	cisbp__M07938	E2F1 (directAnnotation).
PAG1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PAG1	transfac_pro__M12697	ZNF142 (directAnnotation).
PAG1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
PAG1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PAG1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PAG1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PAG1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PAG1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PAG1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PAG1	transfac_pro__M02090	E2F4 (directAnnotation).
PAG1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PAG1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PAG1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PAG1	transfac_pro__M01303	SP1 (directAnnotation).
PAG1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
PAG1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PAG1	metacluster_163.2	ZNF682 (directAnnotation).
PAG1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PAG1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
PAG1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PAG1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PAG1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
PAG1	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
PAG1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PAG1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PAG1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PAG1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PAG1	jaspar__MA0597.2	THAP1 (directAnnotation).
PAG1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PAG1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PAG1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PAG1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
PAG1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PAG1	transfac_pro__M01199	TRIM28 (directAnnotation).
PAG1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PAG1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."