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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OXR1

Summary for OXR1

Gene information	Gene symbol	OXR1
	Ensembl ID	ENSG00000164830
	Entrez ID	55074
	Gene name	oxidation resistance 1
	Synonyms	TLDC3
	Gene type	protein_coding
	UniProtAcc	Q8N573

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Dataset with differentially expressed gene: OXR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.512464	2.19e-02

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Expression of OXR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OXR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OXR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OXR1	hsa-miR-5696	89.8675	NM_001198534
OXR1	hsa-miR-381-3p	89.664	NM_001198532
OXR1	hsa-miR-300	89.664	NM_001198532
OXR1	hsa-miR-4495	89.598	NM_001198534
OXR1	hsa-miR-153-3p	89.2368	NM_001198532
OXR1	hsa-miR-3133	88.9643	NM_001198532
OXR1	hsa-miR-1255b-2-3p	88.9108	NM_001198532
OXR1	hsa-miR-3928-5p	88.4697	NM_001198532
OXR1	hsa-miR-6806-3p	88.4697	NM_001198532
OXR1	hsa-miR-129-5p	88.4621	NM_001198534
OXR1	hsa-miR-93-5p	88.0694	NM_001198532
OXR1	hsa-miR-519d-3p	88.0694	NM_001198532
OXR1	hsa-miR-106a-5p	88.0694	NM_001198532
OXR1	hsa-miR-526b-3p	88.0694	NM_001198532
OXR1	hsa-miR-17-5p	88.0694	NM_001198532
OXR1	hsa-miR-20b-5p	88.0694	NM_001198532
OXR1	hsa-miR-4645-3p	86.613	NM_001198534
OXR1	hsa-miR-4700-3p	86.5295	NM_001198532
OXR1	hsa-miR-127-5p	86.5221	NM_001198532
OXR1	hsa-miR-1208	86.1781	NM_001198532
OXR1	hsa-miR-1283	86.0841	NM_001198532
OXR1	hsa-miR-214-3p	85.8481	NM_001198532
OXR1	hsa-miR-3619-5p	85.8481	NM_001198532
OXR1	hsa-miR-761	85.8481	NM_001198532
OXR1	hsa-miR-8060	85.6614	NM_001198532
OXR1	hsa-miR-7-5p	85.3934	NM_001198532
OXR1	hsa-miR-29b-2-5p	85.2468	NM_001198534
OXR1	hsa-miR-4715-3p	84.6017	NM_001198532
OXR1	hsa-miR-12121	84.6017	NM_001198532
OXR1	hsa-miR-365b-3p	84.5256	NM_001198532
OXR1	hsa-miR-365a-3p	84.5256	NM_001198532
OXR1	hsa-miR-5699-5p	84.3792	NM_001198534
OXR1	hsa-miR-4311	84.3705	NM_001198534
OXR1	hsa-miR-548ao-3p	84.2667	NM_001198532
OXR1	hsa-miR-3145-5p	83.9877	NM_001198534
OXR1	hsa-miR-380-3p	83.4493	NM_001198534
OXR1	hsa-miR-411-3p	83.4493	NM_001198534
OXR1	hsa-miR-379-3p	83.4493	NM_001198534
OXR1	hsa-miR-3923	83.1624	NM_001198534
OXR1	hsa-miR-1250-3p	83.0859	NM_001198534
OXR1	hsa-miR-3667-3p	82.4202	NM_001198534
OXR1	hsa-miR-4775	81.5736	NM_001198534
OXR1	hsa-miR-4422	81.4112	NM_001198532
OXR1	hsa-miR-10395-3p	81.3072	NM_001198532
OXR1	hsa-miR-1976	80.7114	NM_001198534
OXR1	hsa-miR-32-3p	80.6532	NM_001198532
OXR1	hsa-miR-4482-3p	80.6371	NM_001198534
OXR1	hsa-miR-3663-3p	80.463	NM_001198532
OXR1	hsa-miR-182-5p	80.1445	NM_001198532

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Motifs and transcription factors (TFs) regulating OXR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OXR1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
OXR1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
OXR1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
OXR1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
OXR1	transfac_pro__M04617	ZBTB7A (directAnnotation).
OXR1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
OXR1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
OXR1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
OXR1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
OXR1	transfac_pro__M07387	ZBTB7A (directAnnotation).
OXR1	transfac_pro__M07436	WT1 (directAnnotation).
OXR1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
OXR1	transfac_pro__M00716	ZBTB14 (directAnnotation).
OXR1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
OXR1	hdpi__HIP2	UBE2K (directAnnotation).
OXR1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
OXR1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
OXR1	transfac_pro__M04893	TAF1 (directAnnotation).
OXR1	transfac_pro__M03876	ZBTB33 (directAnnotation).
OXR1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
OXR1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
OXR1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
OXR1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
OXR1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."