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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OSBPL11

Summary for OSBPL11

Gene information	Gene symbol	OSBPL11
	Ensembl ID	ENSG00000144909
	Entrez ID	114885
	Gene name	oxysterol binding protein like 11
	Synonyms	FLJ13012\|FLJ13164\|ORP-11\|ORP11
	Gene type	protein_coding
	UniProtAcc	Q9BXB4

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Dataset with differentially expressed gene: OSBPL11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.329303	1.37e-10

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Expression of OSBPL11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OSBPL11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OSBPL11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OSBPL11	hsa-miR-6134	85.1507	NM_022776
OSBPL11	hsa-miR-4517	85.0911	NM_022776
OSBPL11	hsa-miR-7158-5p	84.9924	NM_022776
OSBPL11	hsa-miR-7156-5p	84.7476	NM_022776
OSBPL11	hsa-miR-2117	84.6901	NM_022776
OSBPL11	hsa-miR-548aa	84.3863	NM_022776
OSBPL11	hsa-miR-548t-3p	84.3863	NM_022776
OSBPL11	hsa-miR-548ap-3p	84.3863	NM_022776
OSBPL11	hsa-miR-4520-3p	84.0097	NM_022776
OSBPL11	hsa-miR-935	82.6322	NM_022776
OSBPL11	hsa-miR-194-5p	82.6057	NM_022776
OSBPL11	hsa-miR-3941	82.129	NM_022776
OSBPL11	hsa-miR-19a-3p	81.8497	NM_022776
OSBPL11	hsa-miR-19b-3p	81.8497	NM_022776
OSBPL11	hsa-miR-593-5p	81.8131	NM_022776
OSBPL11	hsa-miR-9851-3p	81.8131	NM_022776
OSBPL11	hsa-miR-4273	81.7318	NM_022776
OSBPL11	hsa-miR-4729	81.7085	NM_022776
OSBPL11	hsa-miR-4328	81.6691	NM_022776
OSBPL11	hsa-miR-3065-5p	81.1098	NM_022776
OSBPL11	hsa-miR-3662	80.5088	NM_022776
OSBPL11	hsa-miR-3613-3p	80.1524	NM_022776

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Motifs and transcription factors (TFs) regulating OSBPL11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OSBPL11	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
OSBPL11	jaspar__MA1633.2	BACH1 (directAnnotation).
OSBPL11	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."