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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ONECUT2

Summary for ONECUT2

Gene information	Gene symbol	ONECUT2
	Ensembl ID	ENSG00000119547
	Entrez ID	9480
	Gene name	one cut homeobox 2
	Synonyms	OC-2
	Gene type	protein_coding
	UniProtAcc	O95948

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Dataset with differentially expressed gene: ONECUT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.289482	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.944013	0.00e+00

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Expression of ONECUT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ONECUT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ONECUT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ONECUT2	hsa-miR-5004-3p	95.8065	NM_004852
ONECUT2	hsa-miR-6891-3p	95.7988	NM_004852
ONECUT2	hsa-miR-12136	95.6944	NM_004852
ONECUT2	hsa-miR-4251	95.5473	NM_004852
ONECUT2	hsa-miR-2115-5p	95.4401	NM_004852
ONECUT2	hsa-miR-6867-5p	95.3788	NM_004852
ONECUT2	hsa-miR-944	95.263	NM_004852
ONECUT2	hsa-miR-1290	94.7855	NM_004852
ONECUT2	hsa-miR-578	94.619	NM_004852
ONECUT2	hsa-miR-607	94.5362	NM_004852
ONECUT2	hsa-miR-6832-3p	94.4661	NM_004852
ONECUT2	hsa-let-7g-5p	94.4158	NM_004852
ONECUT2	hsa-miR-130b-5p	94.2843	NM_004852
ONECUT2	hsa-miR-6833-3p	94.1124	NM_004852
ONECUT2	hsa-miR-5582-5p	94.0121	NM_004852
ONECUT2	hsa-miR-597-3p	94.0029	NM_004852
ONECUT2	hsa-miR-548as-3p	93.9504	NM_004852
ONECUT2	hsa-miR-4724-3p	93.8256	NM_004852
ONECUT2	hsa-miR-4768-5p	93.7968	NM_004852
ONECUT2	hsa-miR-6124	93.7641	NM_004852
ONECUT2	hsa-let-7c-5p	93.752	NM_004852
ONECUT2	hsa-let-7e-5p	93.752	NM_004852
ONECUT2	hsa-miR-98-5p	93.752	NM_004852
ONECUT2	hsa-let-7a-5p	93.752	NM_004852
ONECUT2	hsa-let-7f-5p	93.752	NM_004852
ONECUT2	hsa-miR-875-3p	93.6157	NM_004852
ONECUT2	hsa-miR-6876-5p	93.5326	NM_004852
ONECUT2	hsa-miR-6079	93.5162	NM_004852
ONECUT2	hsa-miR-7162-5p	93.4218	NM_004852
ONECUT2	hsa-miR-516b-3p	93.4218	NM_004852
ONECUT2	hsa-miR-516a-3p	93.4218	NM_004852
ONECUT2	hsa-miR-335-3p	93.4084	NM_004852
ONECUT2	hsa-miR-4659a-3p	93.3392	NM_004852
ONECUT2	hsa-miR-4659b-3p	93.3392	NM_004852
ONECUT2	hsa-miR-548ar-3p	93.2783	NM_004852
ONECUT2	hsa-miR-4458	93.2418	NM_004852
ONECUT2	hsa-miR-4775	93.1621	NM_004852
ONECUT2	hsa-miR-144-3p	93.1581	NM_004852
ONECUT2	hsa-miR-4476	93.0777	NM_004852
ONECUT2	hsa-miR-182-3p	93.0445	NM_004852
ONECUT2	hsa-miR-5582-3p	92.9885	NM_004852
ONECUT2	hsa-miR-29b-2-5p	92.9037	NM_004852
ONECUT2	hsa-let-7i-5p	92.8993	NM_004852
ONECUT2	hsa-let-7b-5p	92.8993	NM_004852
ONECUT2	hsa-miR-211-5p	92.8045	NM_004852
ONECUT2	hsa-miR-204-5p	92.8045	NM_004852
ONECUT2	hsa-miR-181d-5p	92.7177	NM_004852
ONECUT2	hsa-miR-2467-3p	92.6304	NM_004852
ONECUT2	hsa-miR-545-3p	92.6298	NM_004852
ONECUT2	hsa-miR-1231	92.509	NM_004852

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Motifs and transcription factors (TFs) regulating ONECUT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ONECUT2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ONECUT2	metacluster_7.13	ZFX (directAnnotation).
ONECUT2	transfac_pro__M01175	ZBTB7B (directAnnotation).
ONECUT2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ONECUT2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ONECUT2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ONECUT2	transfac_pro__M02089	E2F3 (directAnnotation).
ONECUT2	metacluster_3.14	WT1; WT1 (directAnnotation).
ONECUT2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ONECUT2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ONECUT2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ONECUT2	cisbp__M07938	E2F1 (directAnnotation).
ONECUT2	transfac_pro__M07436	WT1 (directAnnotation).
ONECUT2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ONECUT2	transfac_pro__M02898	SMAD3 (directAnnotation).
ONECUT2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ONECUT2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ONECUT2	cisbp__M00968	MTF2 (directAnnotation).
ONECUT2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ONECUT2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ONECUT2	cisbp__M00341	PAX6 (directAnnotation).
ONECUT2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ONECUT2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ONECUT2	cisbp__M00788	ZFY (inferredBy_Orthology).
ONECUT2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ONECUT2	hdpi__ZNF304	ZNF304 (directAnnotation).
ONECUT2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ONECUT2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ONECUT2	transfac_pro__M01199	TRIM28 (directAnnotation).
ONECUT2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ONECUT2	metacluster_151.2	ZNF23 (directAnnotation).
ONECUT2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ONECUT2	transfac_pro__M03806	ZBTB7C (directAnnotation).
ONECUT2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."