Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NSD2

Summary for NSD2

Gene information	Gene symbol	NSD2
	Ensembl ID	ENSG00000109685
	Entrez ID	7468
	Gene name	nuclear receptor binding SET domain protein 2
	Synonyms	KMT3G\|MMSET\|WHSC1
	Gene type	protein_coding
	UniProtAcc	O96028

Top

Dataset with differentially expressed gene: NSD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.649949	3.73e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.275306	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-1.08654	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.394192	0.00e+00

Top

Expression of NSD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NSD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NSD2	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating NSD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NSD2	hsa-miR-485-5p	84.9471	NM_133331
NSD2	hsa-miR-297	84.8162	NM_007331
NSD2	hsa-miR-548ah-3p	84.6851	NM_133331
NSD2	hsa-miR-548ae-3p	84.6851	NM_133331
NSD2	hsa-miR-548aq-3p	84.6851	NM_133331
NSD2	hsa-miR-548am-3p	84.6851	NM_133331
NSD2	hsa-miR-548j-3p	84.6851	NM_133331
NSD2	hsa-miR-200b-5p	84.6638	NM_133334
NSD2	hsa-miR-200a-5p	84.6638	NM_133334
NSD2	hsa-miR-4524a-5p	84.5504	NM_133334
NSD2	hsa-miR-4524b-5p	84.5504	NM_133334
NSD2	hsa-miR-1297	84.182	NM_133331
NSD2	hsa-miR-1324	83.9074	NM_007331
NSD2	hsa-miR-587	83.8315	NM_133334
NSD2	hsa-miR-3618	83.7974	NM_007331
NSD2	hsa-miR-3613-3p	83.6569	NM_133331
NSD2	hsa-miR-590-3p	83.6282	NM_133334
NSD2	hsa-miR-3127-5p	83.5951	NM_133334
NSD2	hsa-miR-203a-3p	83.4486	NM_133334
NSD2	hsa-miR-5680	83.3184	NM_133334
NSD2	hsa-miR-5692a	83.0139	NM_133334
NSD2	hsa-miR-6747-3p	82.9742	NM_133334
NSD2	hsa-miR-2467-3p	82.709	NM_133334
NSD2	hsa-miR-6813-3p	82.559	NM_133334
NSD2	hsa-miR-4261	82.3629	NM_007331
NSD2	hsa-miR-4445-3p	82.2084	NM_007331
NSD2	hsa-miR-548al	82.2084	NM_007331
NSD2	hsa-miR-5681a	81.7116	NM_007331
NSD2	hsa-miR-580-3p	81.262	NM_133331
NSD2	hsa-miR-153-5p	80.8791	NM_133334
NSD2	hsa-miR-6781-3p	80.7943	NM_133334
NSD2	hsa-miR-548ah-5p	80.503	NM_133331
NSD2	hsa-miR-3609	80.503	NM_133331

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating NSD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."