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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NRXN1

Summary for NRXN1

Gene information	Gene symbol	NRXN1
	Ensembl ID	ENSG00000179915
	Entrez ID	9378
	Gene name	neurexin 1
	Synonyms	Hs.22998\|KIAA0578
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NRXN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.410188	0.00e+00

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Expression of NRXN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRXN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRXN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRXN1	hsa-miR-539-3p	90.7282	NM_001135659
NRXN1	hsa-miR-4477a	90.2658	NM_001135659
NRXN1	hsa-miR-6513-3p	90.2646	NM_001135659
NRXN1	hsa-miR-548a-5p	90.1547	NM_138735
NRXN1	hsa-miR-548ar-5p	90.1547	NM_138735
NRXN1	hsa-miR-4307	90.085	NM_138735
NRXN1	hsa-miR-19a-5p	90.064	NM_138735
NRXN1	hsa-miR-548aw	89.9923	NM_001135659
NRXN1	hsa-miR-3662	89.8045	NM_001135659
NRXN1	hsa-miR-2054	89.7633	NM_138735
NRXN1	hsa-miR-10b-3p	89.0548	NM_001135659
NRXN1	hsa-miR-3121-5p	88.8921	NM_138735
NRXN1	hsa-miR-190a-3p	88.7783	NM_138735
NRXN1	hsa-miR-570-3p	88.2306	NM_001135659
NRXN1	hsa-miR-6885-3p	88.1815	NM_138735
NRXN1	hsa-miR-3976	88.1108	NM_138735
NRXN1	hsa-miR-5580-3p	87.9946	NM_138735
NRXN1	hsa-miR-559	87.936	NM_138735
NRXN1	hsa-miR-548b-5p	87.9037	NM_138735
NRXN1	hsa-miR-548ad-5p	87.9037	NM_138735
NRXN1	hsa-miR-548j-5p	87.9037	NM_138735
NRXN1	hsa-miR-548as-5p	87.9037	NM_138735
NRXN1	hsa-miR-548i	87.9037	NM_138735
NRXN1	hsa-miR-548o-5p	87.9037	NM_138735
NRXN1	hsa-miR-548bb-5p	87.9037	NM_138735
NRXN1	hsa-miR-548ae-5p	87.9037	NM_138735
NRXN1	hsa-miR-548w	87.9037	NM_138735
NRXN1	hsa-miR-548h-5p	87.9037	NM_138735
NRXN1	hsa-miR-548ab	87.9037	NM_138735
NRXN1	hsa-miR-548au-5p	87.9037	NM_138735
NRXN1	hsa-miR-548y	87.9037	NM_138735
NRXN1	hsa-miR-548ap-5p	87.9037	NM_138735
NRXN1	hsa-miR-548c-5p	87.9037	NM_138735
NRXN1	hsa-miR-548am-5p	87.9037	NM_138735
NRXN1	hsa-miR-548ak	87.9037	NM_138735
NRXN1	hsa-miR-548ay-5p	87.9037	NM_138735
NRXN1	hsa-miR-548d-5p	87.9037	NM_138735
NRXN1	hsa-miR-3646	87.5679	NM_138735
NRXN1	hsa-miR-320a-3p	87.133	NM_001135659
NRXN1	hsa-miR-4429	87.133	NM_001135659
NRXN1	hsa-miR-320c	87.133	NM_001135659
NRXN1	hsa-miR-320d	87.133	NM_001135659
NRXN1	hsa-miR-320b	87.133	NM_001135659
NRXN1	hsa-miR-141-3p	87.1247	NM_001135659
NRXN1	hsa-miR-200a-3p	87.1247	NM_001135659
NRXN1	hsa-miR-2113	86.8775	NM_001135659
NRXN1	hsa-miR-550b-2-5p	86.8403	NM_001135659
NRXN1	hsa-miR-6760-3p	85.8188	NM_138735
NRXN1	hsa-miR-548aq-5p	85.5904	NM_138735
NRXN1	hsa-miR-548f-5p	85.5193	NM_001135659

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Motifs and transcription factors (TFs) regulating NRXN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRXN1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NRXN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NRXN1	transfac_pro__M07397	ZNF148 (directAnnotation).
NRXN1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NRXN1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NRXN1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NRXN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NRXN1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NRXN1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NRXN1	transfac_pro__M01175	ZBTB7B (directAnnotation).
NRXN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NRXN1	tfdimers__MD00151	CHURC1 (directAnnotation).
NRXN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NRXN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NRXN1	transfac_pro__M01303	SP1 (directAnnotation).
NRXN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NRXN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NRXN1	transfac_pro__M02090	E2F4 (directAnnotation).
NRXN1	transfac_pro__M01714	KLF15 (directAnnotation).
NRXN1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NRXN1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NRXN1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NRXN1	transfac_pro__M02089	E2F3 (directAnnotation).
NRXN1	metacluster_3.14	WT1; WT1 (directAnnotation).
NRXN1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NRXN1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NRXN1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NRXN1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NRXN1	cisbp__M07938	E2F1 (directAnnotation).
NRXN1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NRXN1	transfac_pro__M07436	WT1 (directAnnotation).
NRXN1	transfac_pro__M02281	SP1 (directAnnotation).
NRXN1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NRXN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NRXN1	transfac_pro__M02898	SMAD3 (directAnnotation).
NRXN1	transfac_public__M00491	PATZ1 (directAnnotation).
NRXN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NRXN1	"Calcium citrate"	DB11093	small molecule
NRXN1	"Calcium phosphate dihydrate"	DB14481	small molecule
NRXN1	"Calcium Phosphate"	DB11348	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."