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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NRN1

Summary for NRN1

Gene information	Gene symbol	NRN1
	Ensembl ID	ENSG00000124785
	Entrez ID	51299
	Gene name	neuritin 1
	Synonyms	NRN
	Gene type	protein_coding
	UniProtAcc	Q9NPD7

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Dataset with differentially expressed gene: NRN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.38867	2.64e-34

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Expression of NRN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRN1	hsa-miR-4324	85.1753	NM_001278710
NRN1	hsa-miR-4470	84.3853	NM_001278710
NRN1	hsa-miR-4784	84.2033	NM_001278710
NRN1	hsa-miR-3150b-3p	84.2033	NM_001278710
NRN1	hsa-miR-12132	84.176	NM_001278710
NRN1	hsa-miR-548an	84.031	NM_001278710
NRN1	hsa-miR-1304-3p	84.0298	NM_001278710
NRN1	hsa-miR-4801	83.5654	NM_001278710
NRN1	hsa-miR-4731-3p	83.5654	NM_001278710
NRN1	hsa-miR-551b-5p	81.815	NM_001278710
NRN1	hsa-miR-374a-5p	80.7717	NM_001278710
NRN1	hsa-miR-4779	80.3201	NM_001278710

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Motifs and transcription factors (TFs) regulating NRN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRN1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
NRN1	transfac_pro__M04826	EP300 (directAnnotation).
NRN1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NRN1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NRN1	transfac_pro__M04950	EGR1 (directAnnotation).
NRN1	transfac_pro__M04944	GABPA (directAnnotation).
NRN1	transfac_pro__M00652	NRF1 (directAnnotation).
NRN1	swissregulon__hs__ETV6	ETV6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."