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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: NFIX

Summary for NFIX

Gene information	Gene symbol	NFIX
	Ensembl ID	ENSG00000008441
	Entrez ID	4784
	Gene name	nuclear factor I X
	Synonyms	NF1A
	Gene type	protein_coding
	UniProtAcc	Q14938

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Dataset with differentially expressed gene: NFIX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.322762	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.338393	5.34e-03
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.317057	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.303331	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.262982	6.10e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.363712	5.96e-29

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Expression of NFIX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NFIX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NFIX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NFIX	hsa-miR-608	88.2483	NM_001271043
NFIX	hsa-miR-4742-5p	88.1063	NM_001271044
NFIX	hsa-miR-6887-3p	88.047	NM_001271044
NFIX	hsa-miR-4447	87.8627	NM_001271043
NFIX	hsa-miR-6829-5p	87.7156	NM_001271044
NFIX	hsa-miR-10396b-5p	87.6022	NM_001271043
NFIX	hsa-miR-3154	87.4763	NM_001271044
NFIX	hsa-miR-6132	87.3994	NM_001271044
NFIX	hsa-miR-6836-5p	87.3904	NM_001271044
NFIX	hsa-miR-328-5p	87.1127	NM_001271043
NFIX	hsa-miR-149-5p	87.0878	NM_001271043
NFIX	hsa-miR-485-3p	87.0753	NM_001271043
NFIX	hsa-miR-539-3p	87.0753	NM_001271043
NFIX	hsa-miR-6762-3p	86.7471	NM_001271044
NFIX	hsa-miR-3909	86.5588	NM_001271043
NFIX	hsa-miR-7109-5p	86.4231	NM_001271044
NFIX	hsa-miR-4656	86.2059	NM_001271044
NFIX	hsa-miR-6887-5p	85.7625	NM_001271043
NFIX	hsa-miR-6795-5p	85.7625	NM_001271043
NFIX	hsa-miR-1908-5p	85.4876	NM_001271043
NFIX	hsa-miR-6787-5p	85.4876	NM_001271043
NFIX	hsa-miR-3924	85.0278	NM_001271043
NFIX	hsa-miR-1237-5p	84.759	NM_001271043
NFIX	hsa-miR-4488	84.1178	NM_001271043
NFIX	hsa-miR-4697-5p	84.1178	NM_001271043
NFIX	hsa-miR-6793-5p	84.1126	NM_001271043
NFIX	hsa-miR-4659b-3p	84.0835	NM_001271044
NFIX	hsa-miR-4659a-3p	84.0835	NM_001271044
NFIX	hsa-miR-581	83.8355	NM_001271044
NFIX	hsa-miR-3191-3p	83.5053	NM_001271044
NFIX	hsa-miR-375-3p	82.8178	NM_001271044
NFIX	hsa-miR-6885-5p	82.6688	NM_001271043
NFIX	hsa-miR-1295b-5p	82.3655	NM_001271043
NFIX	hsa-miR-3529-3p	81.7392	NM_001271043
NFIX	hsa-miR-124-3p	81.5384	NM_001271044
NFIX	hsa-miR-506-3p	81.5384	NM_001271044
NFIX	hsa-miR-6131	81.0462	NM_001271044
NFIX	hsa-miR-4758-3p	80.6361	NM_001271044
NFIX	hsa-miR-504-5p	80.1186	NM_001271044
NFIX	hsa-miR-4725-5p	80.1186	NM_001271044

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Motifs and transcription factors (TFs) regulating NFIX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NFIX	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NFIX	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NFIX	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NFIX	transfac_pro__M01714	KLF15 (directAnnotation).
NFIX	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NFIX	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
NFIX	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NFIX	transfac_pro__M02281	SP1 (directAnnotation).
NFIX	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NFIX	hdpi__FLI1	FLI1 (directAnnotation).
NFIX	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
NFIX	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
NFIX	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
NFIX	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
NFIX	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
NFIX	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
NFIX	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
NFIX	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NFIX	cisbp__M08198	ELF1 (directAnnotation).
NFIX	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
NFIX	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
NFIX	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
NFIX	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
NFIX	transfac_pro__M04748	GABPA (directAnnotation).
NFIX	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
NFIX	transfac_pro__M04950	EGR1 (directAnnotation).
NFIX	transfac_pro__M05706	ZNF20 (directAnnotation).
NFIX	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
NFIX	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
NFIX	transfac_pro__M05712	ZNF134 (directAnnotation).
NFIX	transfac_pro__M06135	ZNF28 (directAnnotation).
NFIX	metacluster_172.6	CHD2; E2F1 (directAnnotation).
NFIX	transfac_pro__M06141	ZNF708 (directAnnotation).
NFIX	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
NFIX	transfac_pro__M06404	ZNF497 (directAnnotation).
NFIX	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
NFIX	jaspar__MA1724.1	RFX6 (inferredBy_Orthology).
NFIX	transfac_pro__M05815	ZNF613 (directAnnotation).
NFIX	tfdimers__MD00032	GFI1; GFI1B; NKX3-2 (directAnnotation).
NFIX	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
NFIX	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
NFIX	metacluster_136.3	MAX; MXI1; MXI1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX4; RFX5; RFX5; RFX5; SREBF1; ZBTB7B (directAnnotation). RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX6; RFX6; RFX6; RFX7; RFX8; RFX8 (inferredBy_Orthology).
NFIX	taipale_tf_pairs__GCM1_FOXI1_NTGTTGATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
NFIX	hdpi__NFIX	up	Malignant cells	GSE131984_JQ1Pal	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."