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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NFIB

Summary for NFIB

Gene information	Gene symbol	NFIB
	Ensembl ID	ENSG00000147862
	Entrez ID	4781
	Gene name	nuclear factor I B
	Synonyms	NFI-RED\|NFIB2\|NFIB3
	Gene type	protein_coding
	UniProtAcc	O00712

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Dataset with differentially expressed gene: NFIB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.698204	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.634797	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.403398	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.839683	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.31534	0.00e+00

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Expression of NFIB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NFIB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NFIB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NFIB	hsa-miR-4509	92.8241	NM_001190737
NFIB	hsa-miR-6875-3p	92.6756	NM_001190737
NFIB	hsa-miR-8062	92.1479	NM_001282787
NFIB	hsa-miR-3688-5p	92.0984	NM_001190737
NFIB	hsa-miR-124-3p	92.0934	NM_001190737
NFIB	hsa-miR-506-3p	92.0934	NM_001190737
NFIB	hsa-miR-3919	92.0896	NM_001190737
NFIB	hsa-miR-4775	92.0114	NM_001190737
NFIB	hsa-miR-4668-5p	91.927	NM_001190737
NFIB	hsa-miR-4328	91.7329	NM_001190737
NFIB	hsa-miR-4273	91.3992	NM_001282787
NFIB	hsa-miR-1184	91.3442	NM_001190737
NFIB	hsa-miR-7977	91.3365	NM_001190737
NFIB	hsa-miR-19b-3p	91.2533	NM_001190737
NFIB	hsa-miR-19a-3p	91.2533	NM_001190737
NFIB	hsa-miR-12122	91.2311	NM_001190737
NFIB	hsa-miR-4282	90.7182	NM_001282787
NFIB	hsa-miR-1252-5p	90.7131	NM_001190737
NFIB	hsa-miR-7850-5p	90.7074	NM_001190737
NFIB	hsa-miR-6516-3p	90.6938	NM_001282787
NFIB	hsa-miR-6791-3p	90.5117	NM_001282787
NFIB	hsa-miR-6829-3p	90.5117	NM_001282787
NFIB	hsa-miR-3614-3p	90.4824	NM_001190737
NFIB	hsa-miR-624-3p	90.2454	NM_001282787
NFIB	hsa-miR-376c-3p	89.9092	NM_001282787
NFIB	hsa-miR-223-3p	89.6235	NM_001282787
NFIB	hsa-miR-7156-3p	89.5657	NM_001190737
NFIB	hsa-miR-7856-5p	89.5225	NM_001190737
NFIB	hsa-miR-539-5p	89.4716	NM_001190737
NFIB	hsa-miR-374c-5p	89.4564	NM_001190737
NFIB	hsa-miR-5688	89.1189	NM_001190737
NFIB	hsa-miR-4520-2-3p	89.0526	NM_001190737
NFIB	hsa-miR-514a-3p	89.0206	NM_001190737
NFIB	hsa-miR-514b-3p	89.0206	NM_001190737
NFIB	hsa-miR-137-3p	88.84	NM_001190737
NFIB	hsa-miR-6773-3p	88.414	NM_001190737
NFIB	hsa-miR-495-3p	88.1726	NM_001190737
NFIB	hsa-miR-596	88.0826	NM_001190737
NFIB	hsa-miR-510-3p	87.8963	NM_001282787
NFIB	hsa-miR-12124	87.8402	NM_001190737
NFIB	hsa-miR-6828-3p	87.7735	NM_001190737
NFIB	hsa-miR-6818-3p	87.7633	NM_001282787
NFIB	hsa-miR-365b-3p	87.606	NM_001190737
NFIB	hsa-miR-365a-3p	87.606	NM_001190737
NFIB	hsa-miR-130b-3p	87.5805	NM_001190737
NFIB	hsa-miR-452-5p	87.5701	NM_001190737
NFIB	hsa-miR-661	87.4456	NM_001282787
NFIB	hsa-miR-494-3p	87.4184	NM_001282787
NFIB	hsa-miR-4661-5p	87.3238	NM_001190737
NFIB	hsa-miR-892c-3p	87.2114	NM_001190737

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Motifs and transcription factors (TFs) regulating NFIB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NFIB	hdpi__NFIX	NFIX (directAnnotation).
NFIB	transfac_pro__M03813	POU3F3 (directAnnotation).
NFIB	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
NFIB	hdpi__ZNF193	ZSCAN9 (directAnnotation).
NFIB	hdpi__FOXM1	FOXM1 (directAnnotation).
NFIB	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
NFIB	transfac_pro__M05768	ZNF544 (directAnnotation).
NFIB	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NFIB	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NFIB	transfac_pro__M07397	ZNF148 (directAnnotation).
NFIB	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NFIB	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NFIB	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NFIB	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NFIB	metacluster_7.13	ZFX (directAnnotation).
NFIB	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NFIB	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NFIB	transfac_pro__M01175	ZBTB7B (directAnnotation).
NFIB	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NFIB	tfdimers__MD00151	CHURC1 (directAnnotation).
NFIB	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NFIB	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NFIB	transfac_pro__M01303	SP1 (directAnnotation).
NFIB	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NFIB	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NFIB	transfac_pro__M02090	E2F4 (directAnnotation).
NFIB	transfac_pro__M01714	KLF15 (directAnnotation).
NFIB	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NFIB	jaspar__MA1122.1	TFDP1 (directAnnotation).
NFIB	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NFIB	transfac_pro__M02089	E2F3 (directAnnotation).
NFIB	metacluster_3.14	WT1; WT1 (directAnnotation).
NFIB	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NFIB	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NFIB	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NFIB	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NFIB	cisbp__M07938	E2F1 (directAnnotation).
NFIB	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NFIB	transfac_pro__M07436	WT1 (directAnnotation).
NFIB	transfac_pro__M02281	SP1 (directAnnotation).
NFIB	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NFIB	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NFIB	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
NFIB	transfac_pro__M02898	SMAD3 (directAnnotation).
NFIB	transfac_public__M00491	PATZ1 (directAnnotation).
NFIB	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NFIB	transfac_pro__M04916	TAF1 (directAnnotation).
NFIB	transfac_pro__M07329	SP7 (directAnnotation).
NFIB	transfac_pro__M01122	ZNF219 (directAnnotation).
NFIB	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."