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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NF1

Summary for NF1

Gene information	Gene symbol	NF1
	Ensembl ID	ENSG00000196712
	Entrez ID	4763
	Gene name	neurofibromin 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P21359

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Dataset with differentially expressed gene: NF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.288915	1.35e-19

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Expression of NF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NF1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating NF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NF1	hsa-miR-6857-3p	88.2587	NM_000267
NF1	hsa-miR-1277-5p	88.1626	NM_000267
NF1	hsa-miR-302b-5p	87.904	NM_000267
NF1	hsa-miR-302d-5p	87.904	NM_000267
NF1	hsa-miR-1468-3p	87.7215	NM_000267
NF1	hsa-miR-4801	87.2998	NM_000267
NF1	hsa-miR-4528	87.2975	NM_000267
NF1	hsa-miR-5692a	86.8055	NM_000267
NF1	hsa-miR-12136	86.6904	NM_001128147
NF1	hsa-miR-182-5p	86.1002	NM_000267
NF1	hsa-miR-195-5p	85.7375	NM_000267
NF1	hsa-miR-15a-5p	85.7375	NM_000267
NF1	hsa-miR-15b-5p	85.7375	NM_000267
NF1	hsa-miR-16-5p	85.7375	NM_000267
NF1	hsa-miR-3911	85.5314	NM_000267
NF1	hsa-miR-4264	85.4554	NM_000267
NF1	hsa-miR-338-5p	85.4038	NM_000267
NF1	hsa-miR-653-5p	85.3637	NM_001128147
NF1	hsa-miR-3613-3p	85.1431	NM_000267
NF1	hsa-miR-302c-5p	84.8553	NM_001128147
NF1	hsa-miR-576-5p	84.7006	NM_001128147
NF1	hsa-miR-589-3p	84.4631	NM_000267
NF1	hsa-miR-4731-3p	84.2931	NM_000267
NF1	hsa-miR-7852-3p	84.2614	NM_001128147
NF1	hsa-miR-3119	84.1433	NM_000267
NF1	hsa-miR-6744-5p	83.8466	NM_000267
NF1	hsa-miR-944	83.5251	NM_000267
NF1	hsa-miR-4720-5p	83.4378	NM_000267
NF1	hsa-miR-5588-5p	83.4378	NM_000267
NF1	hsa-miR-4799-3p	83.4378	NM_000267
NF1	hsa-miR-3074-5p	83.386	NM_000267
NF1	hsa-miR-644a	83.1141	NM_000267
NF1	hsa-miR-6833-3p	83.0912	NM_000267
NF1	hsa-miR-4446-5p	82.0717	NM_000267
NF1	hsa-miR-6838-5p	82.0488	NM_000267
NF1	hsa-miR-497-5p	82.0488	NM_000267
NF1	hsa-miR-424-5p	82.0488	NM_000267
NF1	hsa-miR-4477a	81.9358	NM_001128147
NF1	hsa-let-7b-3p	81.8215	NM_000267
NF1	hsa-let-7a-3p	81.8215	NM_000267
NF1	hsa-miR-98-3p	81.8215	NM_000267
NF1	hsa-let-7f-1-3p	81.8215	NM_000267
NF1	hsa-miR-670-3p	81.3489	NM_000267
NF1	hsa-miR-4768-5p	81.3155	NM_000267
NF1	hsa-miR-876-5p	81.2944	NM_000267
NF1	hsa-miR-27b-3p	80.9709	NM_000267
NF1	hsa-miR-9985	80.9709	NM_000267
NF1	hsa-miR-27a-3p	80.9709	NM_000267
NF1	hsa-miR-3928-3p	80.9531	NM_000267
NF1	hsa-miR-3168	80.8655	NM_000267

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Motifs and transcription factors (TFs) regulating NF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NF1	cisbp__M00968	MTF2 (directAnnotation).
NF1	cisbp__M00341	PAX6 (directAnnotation).
NF1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
NF1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NF1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NF1	metacluster_151.2	ZNF23 (directAnnotation).
NF1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NF1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."