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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NDFIP2

Summary for NDFIP2

Gene information	Gene symbol	NDFIP2
	Ensembl ID	ENSG00000102471
	Entrez ID	54602
	Gene name	Nedd4 family interacting protein 2
	Synonyms	KIAA1165\|N4wbp5a
	Gene type	protein_coding
	UniProtAcc	Q9NV92

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Dataset with differentially expressed gene: NDFIP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.355371	4.64e-23
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.296938	0.00e+00

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Expression of NDFIP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NDFIP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NDFIP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NDFIP2	hsa-miR-548am-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548b-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548ad-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548h-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548c-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548w	86.3751	NM_001161407
NDFIP2	hsa-miR-548bb-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548ar-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548au-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548ab	86.3751	NM_001161407
NDFIP2	hsa-miR-548ay-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548ap-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548o-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548d-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-5093	86.2989	NM_001161407
NDFIP2	hsa-miR-6759-3p	85.8031	NM_001161407
NDFIP2	hsa-miR-4282	85.4584	NM_001161407
NDFIP2	hsa-miR-302a-5p	84.8273	NM_001161407
NDFIP2	hsa-miR-579-3p	84.503	NM_001161407
NDFIP2	hsa-miR-664b-3p	84.503	NM_001161407
NDFIP2	hsa-miR-3920	84.1678	NM_001161407
NDFIP2	hsa-miR-130b-5p	84.1365	NM_001161407
NDFIP2	hsa-miR-548aq-5p	84.0374	NM_001161407
NDFIP2	hsa-miR-7-5p	83.7535	NM_001161407
NDFIP2	hsa-miR-4670-3p	83.7104	NM_001161407
NDFIP2	hsa-miR-302b-5p	82.8155	NM_001161407
NDFIP2	hsa-miR-497-3p	82.3568	NM_001161407
NDFIP2	hsa-miR-4307	82.3129	NM_001161407
NDFIP2	hsa-miR-4789-5p	81.2357	NM_001161407
NDFIP2	hsa-miR-32-3p	81.2143	NM_001161407
NDFIP2	hsa-miR-3972	80.4043	NM_001161407
NDFIP2	hsa-miR-1202	80.4043	NM_001161407
NDFIP2	hsa-miR-6837-3p	80.2928	NM_001161407
NDFIP2	hsa-miR-6887-5p	80.2899	NM_001161407
NDFIP2	hsa-miR-6795-5p	80.2899	NM_001161407

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Motifs and transcription factors (TFs) regulating NDFIP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NDFIP2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NDFIP2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
NDFIP2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NDFIP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NDFIP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
NDFIP2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NDFIP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NDFIP2	jaspar__MA1650.1	ZBTB14 (directAnnotation).
NDFIP2	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
NDFIP2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
NDFIP2	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
NDFIP2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
NDFIP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."