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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCAM1

Summary for NCAM1

Gene information	Gene symbol	NCAM1
	Ensembl ID	ENSG00000149294
	Entrez ID	4684
	Gene name	neural cell adhesion molecule 1
	Synonyms	CD56\|NCAM
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NCAM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.27402	1.77e-29
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.26315	0.00e+00

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Expression of NCAM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCAM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
NCAM1	Malignant cells	CPI-SS05632AB58	NCAM1_FGFR1	NCAM1	FGFR1	False	Malignant cells	Malignant cells	GSE189460	pre	resistant
NCAM1	Malignant cells	CPI-SS05632AB58	NCAM1_FGFR1	NCAM1	FGFR1	False	NK cells	Malignant cells	GSE189460	pre	resistant
NCAM1	Malignant cells	CPI-SS05632AB58	NCAM1_FGFR1	NCAM1	FGFR1	False	Malignant cells	Fibroblasts	GSE189460	pre	resistant
NCAM1	Malignant cells	CPI-SS05632AB58	NCAM1_FGFR1	NCAM1	FGFR1	False	Malignant cells	Fibroblasts	GSE189460	pre	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NCAM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCAM1	hsa-miR-5008-3p	83.9947	NM_000615
NCAM1	hsa-miR-384	83.9096	NM_000615
NCAM1	hsa-miR-1250-3p	83.6933	NM_000615
NCAM1	hsa-miR-3133	83.5938	NM_001242608
NCAM1	hsa-miR-4503	83.2794	NM_001242608
NCAM1	hsa-miR-1283	83.0458	NM_000615
NCAM1	hsa-miR-12136	82.3376	NM_000615
NCAM1	hsa-miR-4505	81.7315	NM_001242608
NCAM1	hsa-miR-4704-5p	81.1971	NM_000615
NCAM1	hsa-miR-5690	81.0269	NM_000615
NCAM1	hsa-miR-5691	80.8498	NM_000615
NCAM1	hsa-miR-6805-3p	80.8498	NM_000615
NCAM1	hsa-miR-3614-5p	80.3313	NM_000615
NCAM1	hsa-miR-4303	80.2324	NM_000615

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Motifs and transcription factors (TFs) regulating NCAM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCAM1	transfac_pro__M06462	ZNF441 (directAnnotation).
NCAM1	transfac_pro__M06441	ZSCAN30 (directAnnotation).
NCAM1	taipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAP	ELK1; SPDEF (directAnnotation).
NCAM1	transfac_pro__M06944	PRDM15 (directAnnotation).
NCAM1	taipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNTGCGGG_CAP	FIGLA; GCM1 (directAnnotation).
NCAM1	taipale_cyt_meth__HSF5_NRCGTTCTAGAAYGYN_eDBD_repr	HSF5 (directAnnotation).
NCAM1	transfac_pro__M06226	ZNF460 (directAnnotation).
NCAM1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
NCAM1	transfac_pro__M01969	FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."