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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NBEA

Summary for NBEA

Gene information	Gene symbol	NBEA
	Ensembl ID	ENSG00000172915
	Entrez ID	26960
	Gene name	neurobeachin
	Synonyms	BCL8B\|FLJ10197\|KIAA1544\|LYST2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NBEA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.413897	0.00e+00

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Expression of NBEA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NBEA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NBEA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NBEA	hsa-miR-6739-3p	89.6122	NM_015678
NBEA	hsa-miR-17-5p	89.506	NM_015678
NBEA	hsa-miR-519d-3p	89.506	NM_015678
NBEA	hsa-miR-20b-5p	89.506	NM_015678
NBEA	hsa-miR-93-5p	89.506	NM_015678
NBEA	hsa-miR-494-3p	89.3133	NM_015678
NBEA	hsa-miR-3680-3p	88.9577	NM_015678
NBEA	hsa-miR-6832-3p	88.4513	NM_015678
NBEA	hsa-miR-100-3p	88.1271	NM_015678
NBEA	hsa-miR-4666a-3p	87.8663	NM_015678
NBEA	hsa-miR-338-5p	87.6725	NM_015678
NBEA	hsa-miR-5582-3p	87.4357	NM_015678
NBEA	hsa-miR-660-5p	87.3493	NM_015678
NBEA	hsa-miR-138-5p	87.2606	NM_015678
NBEA	hsa-miR-190b-5p	87.0481	NM_015678
NBEA	hsa-miR-190a-5p	87.0481	NM_015678
NBEA	hsa-miR-5590-3p	87.0331	NM_015678
NBEA	hsa-miR-142-5p	87.0331	NM_015678
NBEA	hsa-miR-4276	86.409	NM_015678
NBEA	hsa-miR-187-5p	86.0843	NM_015678
NBEA	hsa-miR-1-3p	85.9938	NM_015678
NBEA	hsa-miR-206	85.9938	NM_015678
NBEA	hsa-miR-3119	85.7376	NM_015678
NBEA	hsa-miR-651-3p	85.6293	NM_015678
NBEA	hsa-miR-9718	85.4648	NM_015678
NBEA	hsa-miR-548b-3p	85.4271	NM_015678
NBEA	hsa-miR-3133	85.3043	NM_015678
NBEA	hsa-let-7c-3p	84.7554	NM_015678
NBEA	hsa-miR-4251	84.7467	NM_015678
NBEA	hsa-miR-1207-3p	84.3798	NM_015678
NBEA	hsa-miR-670-3p	84.2055	NM_015678
NBEA	hsa-miR-135a-5p	84.1764	NM_015678
NBEA	hsa-miR-135b-5p	84.1764	NM_015678
NBEA	hsa-miR-4677-5p	83.4731	NM_015678
NBEA	hsa-miR-3165	83.0073	NM_015678
NBEA	hsa-miR-205-3p	82.9515	NM_015678
NBEA	hsa-miR-488-5p	82.7575	NM_015678
NBEA	hsa-miR-6804-3p	82.5849	NM_015678
NBEA	hsa-miR-5197-5p	82.4235	NM_015678
NBEA	hsa-miR-190a-3p	81.7083	NM_015678
NBEA	hsa-miR-628-5p	81.5977	NM_015678
NBEA	hsa-miR-10393-5p	81.5219	NM_001204197
NBEA	hsa-miR-331-3p	81.3974	NM_015678
NBEA	hsa-miR-5187-5p	80.8354	NM_015678
NBEA	hsa-miR-3923	80.3968	NM_015678
NBEA	hsa-miR-613	80.2503	NM_015678
NBEA	hsa-miR-568	80.0569	NM_015678

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Motifs and transcription factors (TFs) regulating NBEA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NBEA	transfac_pro__M06074	ZNF732 (directAnnotation).
NBEA	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
NBEA	transfac_pro__M02843	BBX (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."