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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NABP1

Summary for NABP1

Gene information	Gene symbol	NABP1
	Ensembl ID	ENSG00000173559
	Entrez ID	64859
	Gene name	nucleic acid binding protein 1
	Synonyms	DKFZp667M1322\|FLJ13624\|FLJ22833\|hSSB2\|MGC111163\|NABP1-OT1\|OBFC2A\|SOSS-B2\|SSB2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NABP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.424082	2.81e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.467244	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.257488	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.436083	1.09e-31
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.573461	1.98e-35
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.399154	8.73e-04

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Expression of NABP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NABP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NABP1	Epigenetic Alteration of DNA, RNA or Protein

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MicroRNAs (miRNA) regulating NABP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NABP1	hsa-miR-26a-5p	90.7776	NM_001254736
NABP1	hsa-miR-26b-5p	90.7776	NM_001254736
NABP1	hsa-miR-513a-5p	90.7684	NM_001254736
NABP1	hsa-miR-5688	90.276	NM_001254736
NABP1	hsa-miR-495-3p	89.6387	NM_001254736
NABP1	hsa-miR-3975	89.2327	NM_001254736
NABP1	hsa-miR-4465	87.0914	NM_001254736
NABP1	hsa-miR-548n	87.0223	NM_001254736
NABP1	hsa-miR-3059-5p	85.6137	NM_001254736
NABP1	hsa-miR-4762-3p	85.2395	NM_001254736
NABP1	hsa-miR-3085-5p	85.0187	NM_001031716
NABP1	hsa-miR-651-3p	84.1079	NM_001031716
NABP1	hsa-miR-4761-3p	84.0921	NM_001031716
NABP1	hsa-miR-4691-5p	83.7139	NM_001031716
NABP1	hsa-miR-6792-3p	83.7139	NM_001031716
NABP1	hsa-miR-3163	83.5035	NM_001254736
NABP1	hsa-miR-4659a-3p	83.4068	NM_001254736
NABP1	hsa-miR-4659b-3p	83.4068	NM_001254736
NABP1	hsa-miR-105-5p	83.3946	NM_001031716
NABP1	hsa-miR-7853-5p	83.3946	NM_001031716
NABP1	hsa-miR-520f-5p	82.7447	NM_001031716
NABP1	hsa-miR-6881-3p	82.4714	NM_001254736
NABP1	hsa-miR-320a-3p	82.1324	NM_001031716
NABP1	hsa-miR-320b	82.1324	NM_001031716
NABP1	hsa-miR-320c	82.1324	NM_001031716
NABP1	hsa-miR-320d	82.1324	NM_001031716
NABP1	hsa-miR-4429	82.1324	NM_001031716
NABP1	hsa-miR-4643	81.6157	NM_001031716
NABP1	hsa-miR-3658	81.2368	NM_001254736
NABP1	hsa-miR-548d-3p	80.7714	NM_001031716
NABP1	hsa-miR-4525	80.5297	NM_001031716
NABP1	hsa-miR-5010-5p	80.5297	NM_001031716

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Motifs and transcription factors (TFs) regulating NABP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NABP1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
NABP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NABP1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NABP1	jaspar__MA1483.2	ELF2 (directAnnotation).
NABP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NABP1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
NABP1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
NABP1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NABP1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
NABP1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
NABP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NABP1	transfac_pro__M00652	NRF1 (directAnnotation).
NABP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NABP1	transfac_pro__M04866	HDAC2 (directAnnotation).
NABP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NABP1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
NABP1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
NABP1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
NABP1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
NABP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NABP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NABP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NABP1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
NABP1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NABP1	metacluster_143.14	ZNF320 (directAnnotation).
NABP1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
NABP1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
NABP1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
NABP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NABP1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
NABP1	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
NABP1	transfac_pro__M04617	ZBTB7A (directAnnotation).
NABP1	transfac_pro__M01973	PLAG1 (directAnnotation).
NABP1	metacluster_151.2	ZNF23 (directAnnotation).
NABP1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
NABP1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
NABP1	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
NABP1	cisbp__M01864	EGR1 (inferredBy_Orthology).
NABP1	tfdimers__MD00391	KLF4 (directAnnotation).
NABP1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
NABP1	tfdimers__MD00151	CHURC1 (directAnnotation).
NABP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
NABP1	cisbp__M00139	ZNF281 (inferredBy_Orthology).
NABP1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
NABP1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
NABP1	transfac_public__M00491	PATZ1 (directAnnotation).
NABP1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NABP1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
NABP1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
NABP1	transfac_pro__M01253	CNOT3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."