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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NAB1

Summary for NAB1

Gene information	Gene symbol	NAB1
	Ensembl ID	ENSG00000138386
	Entrez ID	4664
	Gene name	NGFI-A binding protein 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NAB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.507773	0.00e+00

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Expression of NAB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NAB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NAB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NAB1	hsa-miR-4687-3p	86.7859	NM_001321312
NAB1	hsa-miR-513a-3p	86.423	NM_001321312
NAB1	hsa-miR-513c-3p	86.423	NM_001321312
NAB1	hsa-miR-3606-3p	86.2067	NM_001321312
NAB1	hsa-miR-5011-5p	85.8738	NM_001321312
NAB1	hsa-miR-6842-3p	85.4764	NM_001321312
NAB1	hsa-miR-212-5p	85.1052	NM_001321312
NAB1	hsa-miR-493-5p	84.5993	NM_001321312
NAB1	hsa-miR-4262	84.1132	NM_001321312
NAB1	hsa-miR-302c-5p	83.8994	NM_001321312
NAB1	hsa-miR-3064-3p	83.7511	NM_001321312
NAB1	hsa-miR-1827	83.6185	NM_001321312
NAB1	hsa-miR-1-3p	82.6993	NM_001321312
NAB1	hsa-miR-206	82.6993	NM_001321312
NAB1	hsa-miR-613	82.6993	NM_001321312
NAB1	hsa-miR-4534	82.5828	NM_001321312
NAB1	hsa-miR-374a-3p	82.3718	NM_001321312
NAB1	hsa-miR-1251-3p	82.2565	NM_001321312
NAB1	hsa-miR-181c-5p	82.0126	NM_001321312
NAB1	hsa-miR-181d-5p	82.0126	NM_001321312
NAB1	hsa-miR-181a-5p	82.0126	NM_001321312
NAB1	hsa-miR-181b-5p	82.0126	NM_001321312
NAB1	hsa-miR-4477a	81.4448	NM_001321312
NAB1	hsa-miR-5692a	81.3042	NM_001321312
NAB1	hsa-miR-200b-3p	80.8965	NM_001321312
NAB1	hsa-miR-200c-3p	80.8965	NM_001321312
NAB1	hsa-miR-429	80.8965	NM_001321312
NAB1	hsa-miR-1257	80.8037	NM_001321312
NAB1	hsa-miR-6719-3p	80.5885	NM_001321312
NAB1	hsa-miR-548g-3p	80.068	NM_001321312

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Motifs and transcription factors (TFs) regulating NAB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NAB1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
NAB1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
NAB1	cisbp__M04023	CREB1 (directAnnotation).
NAB1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
NAB1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
NAB1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
NAB1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
NAB1	metacluster_111.5	E4F1; E4F1 (directAnnotation).
NAB1	hdpi__NRL	NRL (directAnnotation).
NAB1	transfac_pro__M08803	CREM (directAnnotation).
NAB1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
NAB1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
NAB1	hdpi__RARA	RARA (directAnnotation).
NAB1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
NAB1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NAB1	transfac_pro__M04893	TAF1 (directAnnotation).
NAB1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
NAB1	hdpi__FEZF2	FEZF2 (directAnnotation).
NAB1	hocomoco__FEV_HUMAN.H11MO.0.B	FEV (directAnnotation).
NAB1	hdpi__HIP2	UBE2K (directAnnotation).
NAB1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
NAB1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
NAB1	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
NAB1	hdpi__PDLIM5	PDLIM5 (directAnnotation).
NAB1	transfac_pro__M03846	SMAD5 (directAnnotation).
NAB1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NAB1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
NAB1	transfac_pro__M00938	E2F1 (directAnnotation).
NAB1	transfac_pro__M04817	ZBTB33 (directAnnotation).
NAB1	transfac_pro__M01199	TRIM28 (directAnnotation).
NAB1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NAB1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NAB1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
NAB1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NAB1	hdpi__OTUD4	OTUD4 (directAnnotation).
NAB1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NAB1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NAB1	transfac_pro__M07436	WT1 (directAnnotation).
NAB1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."