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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: N4BP2

Summary for N4BP2

Gene information	Gene symbol	N4BP2
	Ensembl ID	ENSG00000078177
	Entrez ID	55728
	Gene name	NEDD4 binding protein 2
	Synonyms	B3BP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: N4BP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.533581	0.00e+00

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Expression of N4BP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to N4BP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating N4BP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
N4BP2	hsa-miR-3529-3p	81.923	NM_018177
N4BP2	hsa-miR-1-5p	81.7587	NM_018177
N4BP2	hsa-miR-548l	81.646	NM_018177
N4BP2	hsa-let-7f-1-3p	81.6147	NM_018177
N4BP2	hsa-miR-1185-1-3p	81.5916	NM_018177
N4BP2	hsa-miR-1185-2-3p	81.5916	NM_018177
N4BP2	hsa-miR-33a-3p	80.9914	NM_018177
N4BP2	hsa-miR-3120-5p	80.7671	NM_018177
N4BP2	hsa-miR-548c-3p	80.3941	NM_001318359

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Motifs and transcription factors (TFs) regulating N4BP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
N4BP2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
N4BP2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
N4BP2	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
N4BP2	jaspar__MA0502.2	NFYB (directAnnotation).
N4BP2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
N4BP2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
N4BP2	transfac_pro__M04918	EGR1 (directAnnotation).
N4BP2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
N4BP2	metacluster_7.13	ZFX (directAnnotation).
N4BP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
N4BP2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
N4BP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
N4BP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
N4BP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
N4BP2	cisbp__M00249	WT1 (directAnnotation).
N4BP2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
N4BP2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
N4BP2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
N4BP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
N4BP2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
N4BP2	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."