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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYCN

Summary for MYCN

Gene information	Gene symbol	MYCN
	Ensembl ID	ENSG00000134323
	Entrez ID	4613
	Gene name	MYCN proto-oncogene, bHLH transcription factor
	Synonyms	bHLHe37\|MYCNOT\|N-myc\|NMYC
	Gene type	protein_coding
	UniProtAcc	P04198

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Dataset with differentially expressed gene: MYCN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-1.35858	0.00e+00

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Expression of MYCN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYCN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MYCN	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MYCN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYCN	hsa-miR-548o-5p	94.5929	NM_001293233
MYCN	hsa-miR-548aq-5p	94.5127	NM_001293233
MYCN	hsa-miR-4438	94.2091	NM_001293228
MYCN	hsa-miR-4500	94.1399	NM_001293228
MYCN	hsa-miR-144-3p	94.0938	NM_001293233
MYCN	hsa-miR-338-5p	93.764	NM_001293233
MYCN	hsa-miR-103a-3p	93.714	NM_001293233
MYCN	hsa-miR-107	93.714	NM_001293233
MYCN	hsa-miR-1295b-5p	92.6512	NM_001293233
MYCN	hsa-miR-8068	92.608	NM_001293228
MYCN	hsa-miR-383-3p	92.4594	NM_001293233
MYCN	hsa-miR-29a-3p	92.4134	NM_001293233
MYCN	hsa-miR-29b-3p	92.4134	NM_001293233
MYCN	hsa-miR-29c-3p	92.4134	NM_001293233
MYCN	hsa-miR-548t-5p	91.7594	NM_001293228
MYCN	hsa-miR-548az-5p	91.7594	NM_001293228
MYCN	hsa-miR-7-2-3p	91.7234	NM_001293233
MYCN	hsa-miR-7-1-3p	91.7234	NM_001293233
MYCN	hsa-miR-1250-3p	91.4439	NM_001293228
MYCN	hsa-miR-142-5p	90.5978	NM_001293233
MYCN	hsa-miR-5590-3p	90.5978	NM_001293233
MYCN	hsa-miR-505-3p	90.4027	NM_001293228
MYCN	hsa-miR-765	89.7287	NM_001293233
MYCN	hsa-let-7f-5p	89.2861	NM_001293228
MYCN	hsa-let-7b-5p	89.2861	NM_001293228
MYCN	hsa-let-7a-5p	89.2861	NM_001293228
MYCN	hsa-let-7i-5p	89.2861	NM_001293228
MYCN	hsa-let-7c-5p	89.2861	NM_001293228
MYCN	hsa-let-7g-5p	89.2861	NM_001293228
MYCN	hsa-let-7e-5p	89.2861	NM_001293228
MYCN	hsa-miR-98-5p	89.2861	NM_001293228
MYCN	hsa-miR-5681b	88.9009	NM_001293233
MYCN	hsa-miR-582-5p	88.6454	NM_001293233
MYCN	hsa-miR-4268	88.053	NM_001293233
MYCN	hsa-miR-551b-5p	88.016	NM_001293228
MYCN	hsa-miR-5195-3p	87.7596	NM_001293233
MYCN	hsa-miR-3910	86.9838	NM_001293233
MYCN	hsa-miR-6852-3p	86.7318	NM_001293233
MYCN	hsa-let-7d-5p	86.357	NM_001293228
MYCN	hsa-miR-4458	86.357	NM_001293228
MYCN	hsa-miR-145-5p	85.8639	NM_001293233
MYCN	hsa-miR-502-3p	85.551	NM_001293228
MYCN	hsa-miR-501-3p	85.551	NM_001293228
MYCN	hsa-miR-371a-5p	84.6256	NM_001293233
MYCN	hsa-miR-548av-5p	83.7663	NM_001293233
MYCN	hsa-miR-548k	83.7663	NM_001293233
MYCN	hsa-miR-8054	83.7663	NM_001293233
MYCN	hsa-miR-513b-3p	83.6222	NM_001293233
MYCN	hsa-miR-4456	83.3348	NM_001293233
MYCN	hsa-miR-11181-3p	82.9298	NM_001293233

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Motifs and transcription factors (TFs) regulating MYCN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."