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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MYBL1

Summary for MYBL1

Gene information	Gene symbol	MYBL1
	Ensembl ID	ENSG00000185697
	Entrez ID	4603
	Gene name	MYB proto-oncogene like 1
	Synonyms	A-myb\|AMYB
	Gene type	protein_coding
	UniProtAcc	P10243

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Dataset with differentially expressed gene: MYBL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.297748	8.78e-08
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.449468	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.526746	0.00e+00

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Expression of MYBL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYBL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYBL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYBL1	hsa-miR-6838-5p	93.4359	NM_001080416
MYBL1	hsa-miR-5581-3p	93.1813	NM_001080416
MYBL1	hsa-miR-1468-3p	93.1382	NM_001080416
MYBL1	hsa-miR-4482-3p	91.9366	NM_001080416
MYBL1	hsa-miR-580-3p	91.4912	NM_001080416
MYBL1	hsa-miR-24-2-5p	91.2314	NM_001080416
MYBL1	hsa-miR-24-1-5p	91.2314	NM_001080416
MYBL1	hsa-miR-548av-5p	90.7047	NM_001080416
MYBL1	hsa-miR-548k	90.7047	NM_001080416
MYBL1	hsa-miR-8054	90.7047	NM_001080416
MYBL1	hsa-miR-4697-3p	90.6692	NM_001080416
MYBL1	hsa-miR-20b-3p	90.5975	NM_001080416
MYBL1	hsa-let-7c-3p	90.2149	NM_001080416
MYBL1	hsa-miR-1183	89.9492	NM_001080416
MYBL1	hsa-miR-338-5p	89.9146	NM_001080416
MYBL1	hsa-miR-4262	89.768	NM_001080416
MYBL1	hsa-miR-181c-5p	89.768	NM_001080416
MYBL1	hsa-miR-181b-5p	89.768	NM_001080416
MYBL1	hsa-miR-181d-5p	89.768	NM_001080416
MYBL1	hsa-miR-181a-5p	89.768	NM_001080416
MYBL1	hsa-miR-10522-5p	89.576	NM_001080416
MYBL1	hsa-miR-3185	89.576	NM_001080416
MYBL1	hsa-miR-3065-5p	89.2184	NM_001080416
MYBL1	hsa-miR-3163	89.1783	NM_001080416
MYBL1	hsa-miR-29b-2-5p	87.8471	NM_001080416
MYBL1	hsa-miR-4501	87.4578	NM_001080416
MYBL1	hsa-miR-4766-5p	87.1444	NM_001080416
MYBL1	hsa-miR-4720-5p	86.9986	NM_001080416
MYBL1	hsa-miR-4714-3p	86.7657	NM_001080416
MYBL1	hsa-miR-6512-5p	86.323	NM_001080416
MYBL1	hsa-miR-302f	86.1324	NM_001080416
MYBL1	hsa-miR-891b	85.9641	NM_001080416
MYBL1	hsa-miR-5588-5p	85.1699	NM_001080416
MYBL1	hsa-miR-4799-3p	85.1699	NM_001080416
MYBL1	hsa-miR-3611	84.8794	NM_001080416
MYBL1	hsa-miR-647	84.6858	NM_001080416
MYBL1	hsa-miR-223-3p	84.6613	NM_001080416
MYBL1	hsa-miR-3613-3p	84.4397	NM_001080416
MYBL1	hsa-miR-576-3p	84.3396	NM_001080416
MYBL1	hsa-miR-4795-3p	83.6844	NM_001080416
MYBL1	hsa-miR-221-3p	83.0746	NM_001080416
MYBL1	hsa-miR-4699-3p	82.9132	NM_001080416
MYBL1	hsa-miR-4306	82.6386	NM_001080416
MYBL1	hsa-miR-8080	82.0688	NM_001080416
MYBL1	hsa-miR-1273h-3p	81.757	NM_001080416
MYBL1	hsa-miR-6509-5p	81.4695	NM_001080416
MYBL1	hsa-miR-200a-5p	80.4454	NM_001080416
MYBL1	hsa-miR-200b-5p	80.4454	NM_001080416
MYBL1	hsa-miR-10527-5p	80.3475	NM_001080416
MYBL1	hsa-miR-1244	80.2889	NM_001080416

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Motifs and transcription factors (TFs) regulating MYBL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYBL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MYBL1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
MYBL1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
MYBL1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
MYBL1	jaspar__MA0748.2	YY2 (directAnnotation).
MYBL1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
MYBL1	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
MYBL1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
MYBL1	transfac_pro__M06280	ZFP69 (directAnnotation).
MYBL1	transfac_pro__M05542	SNAPC4 (directAnnotation).
MYBL1	transfac_pro__M05668	ZNF154 (directAnnotation).
MYBL1	cisbp__M00968	MTF2 (directAnnotation).
MYBL1	transfac_pro__M00716	ZBTB14 (directAnnotation).
MYBL1	transfac_pro__M04893	TAF1 (directAnnotation).
MYBL1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
MYBL1	transfac_pro__M02089	E2F3 (directAnnotation).
MYBL1	transfac_pro__M04817	ZBTB33 (directAnnotation).
MYBL1	transfac_pro__M07310	SP5 (directAnnotation).
MYBL1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
MYBL1	hdpi__NRL	NRL (directAnnotation).
MYBL1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MYBL1	hdpi__HIP2	UBE2K (directAnnotation).
MYBL1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MYBL1	transfac_pro__M01783	SP2 (directAnnotation).
MYBL1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MYBL1	cisbp__M07938	E2F1 (directAnnotation).
MYBL1	metacluster_7.13	ZFX (directAnnotation).
MYBL1	tfdimers__MD00483	ZBTB14 (directAnnotation).
MYBL1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
MYBL1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
MYBL1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
MYBL1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
MYBL1	transfac_pro__M03806	ZBTB7C (directAnnotation).
MYBL1	metacluster_135.11	NR2C2 (directAnnotation).
MYBL1	cisbp__M00788	ZFY (inferredBy_Orthology).
MYBL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MYBL1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MYBL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MYBL1	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MYBL1	cisbp__M00343	PAX6 (directAnnotation).
MYBL1	transfac_pro__M00430	E2F1 (directAnnotation).
MYBL1	transfac_pro__M12697	ZNF142 (directAnnotation).
MYBL1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
MYBL1	transfac_pro__M00938	E2F1 (directAnnotation).
MYBL1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
MYBL1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
MYBL1	transfac_pro__M12694	ZFP14 (directAnnotation).
MYBL1	transfac_pro__M01253	CNOT3 (directAnnotation).
MYBL1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MYBL1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MYBL1	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	down	Malignant cells	GSE186960	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."