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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MTSS1

Summary for MTSS1

Gene information	Gene symbol	MTSS1
	Ensembl ID	ENSG00000170873
	Entrez ID	9788
	Gene name	MTSS I-BAR domain containing 1
	Synonyms	KIAA0429\|MIM\|MIMA\|MIMB
	Gene type	protein_coding
	UniProtAcc	O43312

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Dataset with differentially expressed gene: MTSS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.279613	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.250555	8.67e-22
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.284511	4.18e-14
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.456807	4.51e-31
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.57414	5.36e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.491741	1.37e-32
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	B cells	0.256499	2.52e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.282293	1.59e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.508981	0.00e+00

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Expression of MTSS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MTSS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MTSS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MTSS1	hsa-miR-593-5p	85.2034	NM_001282971
MTSS1	hsa-miR-4269	85.1183	NM_001282971
MTSS1	hsa-miR-6715b-5p	85.1183	NM_001282971
MTSS1	hsa-miR-2053	84.723	NM_001282971
MTSS1	hsa-miR-491-5p	84.7216	NM_001282971
MTSS1	hsa-miR-23b-3p	84.6259	NM_001282971
MTSS1	hsa-miR-23a-3p	84.6259	NM_001282971
MTSS1	hsa-miR-23c	84.6259	NM_001282971
MTSS1	hsa-miR-6759-5p	83.931	NM_001282971
MTSS1	hsa-miR-140-5p	83.7834	NM_001282971
MTSS1	hsa-miR-6774-5p	83.2034	NM_001282971
MTSS1	hsa-miR-635	83.2034	NM_001282971
MTSS1	hsa-miR-4700-3p	82.3774	NM_001282971
MTSS1	hsa-miR-4714-3p	82.3362	NM_001282971
MTSS1	hsa-miR-6878-5p	82.1556	NM_001282971
MTSS1	hsa-miR-3910	81.851	NM_001282971
MTSS1	hsa-miR-7-2-3p	81.7655	NM_001282971
MTSS1	hsa-miR-7-1-3p	81.7655	NM_001282971
MTSS1	hsa-miR-194-5p	80.5597	NM_001282971
MTSS1	hsa-miR-1255b-2-3p	80.2536	NM_001282971

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Motifs and transcription factors (TFs) regulating MTSS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MTSS1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MTSS1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
MTSS1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MTSS1	transfac_pro__M01303	SP1 (directAnnotation).
MTSS1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MTSS1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MTSS1	transfac_pro__M02090	E2F4 (directAnnotation).
MTSS1	transfac_pro__M02089	E2F3 (directAnnotation).
MTSS1	metacluster_3.14	WT1; WT1 (directAnnotation).
MTSS1	cisbp__M07938	E2F1 (directAnnotation).
MTSS1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MTSS1	transfac_pro__M02898	SMAD3 (directAnnotation).
MTSS1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
MTSS1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
MTSS1	transfac_pro__M01783	SP2 (directAnnotation).
MTSS1	transfac_pro__M01253	CNOT3 (directAnnotation).
MTSS1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MTSS1	cisbp__M00968	MTF2 (directAnnotation).
MTSS1	transfac_pro__M04817	ZBTB33 (directAnnotation).
MTSS1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MTSS1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MTSS1	metacluster_84.16	RARB (directAnnotation).
MTSS1	transfac_pro__M06959	ZNF425 (directAnnotation).
MTSS1	swissregulon__hs__ZNF691	ZNF691 (directAnnotation).
MTSS1	transfac_pro__M01877	GATA2 (directAnnotation).
MTSS1	kznf__ZNF33A_Najafabadi2015_ChIP-seq	ZNF33A (directAnnotation).
MTSS1	transfac_pro__M02919	HNF1A (inferredBy_Orthology).
MTSS1	transfac_pro__M07607	NFATC3 (directAnnotation).
MTSS1	metacluster_84.15	RARB (inferredBy_Orthology).
MTSS1	taipale_tf_pairs__FOXJ2_PITX1_TAAACAGGATTA_CAP_repr	FOXJ2; PITX1 (directAnnotation).
MTSS1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
MTSS1	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
MTSS1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
MTSS1	transfac_pro__M04916	TAF1 (directAnnotation).
MTSS1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MTSS1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MTSS1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
MTSS1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MTSS1	jaspar__MA1721.1	ZNF93 (directAnnotation).
MTSS1	metacluster_151.2	ZNF23 (directAnnotation).
MTSS1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MTSS1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
MTSS1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MTSS1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
MTSS1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
MTSS1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MTSS1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
MTSS1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MTSS1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MTSS1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."