Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MSI2

Summary for MSI2

Gene information	Gene symbol	MSI2
	Ensembl ID	ENSG00000153944
	Entrez ID	124540
	Gene name	musashi RNA binding protein 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: MSI2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.542811	3.65e-34
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.318056	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.615754	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.609009	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.39605	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.347905	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.408236	4.85e-26
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.465346	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.373269	7.08e-27
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.312943	0.00e+00

Top

Expression of MSI2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MSI2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MSI2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MSI2	hsa-miR-101-3p	91.1813	NM_001322250
MSI2	hsa-miR-3619-3p	91.1381	NM_001322250
MSI2	hsa-miR-4307	91.0266	NM_001322250
MSI2	hsa-miR-548c-3p	90.788	NM_001322250
MSI2	hsa-miR-1913	90.7356	NM_001322250
MSI2	hsa-miR-30b-5p	90.2301	NM_001322250
MSI2	hsa-miR-30d-5p	90.2301	NM_001322250
MSI2	hsa-miR-30e-5p	90.2301	NM_001322250
MSI2	hsa-miR-30a-5p	90.2301	NM_001322250
MSI2	hsa-miR-30c-5p	90.2301	NM_001322250
MSI2	hsa-miR-410-3p	90.0349	NM_001322250
MSI2	hsa-miR-4679	89.9051	NM_001322250
MSI2	hsa-miR-6515-3p	89.7955	NM_001322250
MSI2	hsa-miR-6887-5p	89.7783	NM_001322250
MSI2	hsa-miR-583	89.6318	NM_001322250
MSI2	hsa-miR-6778-3p	89.532	NM_001322250
MSI2	hsa-miR-7853-5p	89.4927	NM_170721
MSI2	hsa-miR-105-5p	89.4927	NM_170721
MSI2	hsa-miR-374a-5p	89.37	NM_001322250
MSI2	hsa-miR-501-5p	89.3426	NM_001322250
MSI2	hsa-miR-150-3p	89.1414	NM_001322250
MSI2	hsa-miR-548e-5p	89.1253	NM_001322250
MSI2	hsa-miR-4719	88.964	NM_001322250
MSI2	hsa-miR-1290	88.5945	NM_001322250
MSI2	hsa-miR-11399	88.5731	NM_001322250
MSI2	hsa-miR-642a-5p	88.4937	NM_001322250
MSI2	hsa-miR-3065-5p	88.4374	NM_001322250
MSI2	hsa-miR-5580-3p	88.3823	NM_001322250
MSI2	hsa-miR-1179	88.0789	NM_001322250
MSI2	hsa-miR-4531	87.9935	NM_001322250
MSI2	hsa-miR-3924	87.9581	NM_001322250
MSI2	hsa-miR-28-3p	87.4797	NM_001322250
MSI2	hsa-miR-6795-5p	87.3521	NM_001322250
MSI2	hsa-miR-1277-5p	87.3517	NM_001322250
MSI2	hsa-miR-4328	87.2413	NM_001322250
MSI2	hsa-miR-8066	87.149	NM_001322250
MSI2	hsa-miR-1-5p	87.0653	NM_001322250
MSI2	hsa-miR-374b-5p	86.879	NM_001322250
MSI2	hsa-miR-3920	86.8297	NM_001322250
MSI2	hsa-miR-1283	86.6681	NM_001322250
MSI2	hsa-miR-130b-5p	86.611	NM_001322250
MSI2	hsa-miR-4310	86.5178	NM_001322250
MSI2	hsa-miR-19a-3p	86.3685	NM_001322250
MSI2	hsa-miR-19b-3p	86.3685	NM_001322250
MSI2	hsa-miR-8063	86.3195	NM_001322250
MSI2	hsa-miR-361-3p	86.2583	NM_001322250
MSI2	hsa-miR-3689d	86.2517	NM_001322250
MSI2	hsa-miR-6851-5p	86.2517	NM_001322250
MSI2	hsa-miR-518c-5p	85.9904	NM_001322250
MSI2	hsa-miR-2467-3p	85.9464	NM_001322250

Page: 1 2 3 4

Top

Motifs and transcription factors (TFs) regulating MSI2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MSI2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MSI2	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
MSI2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
MSI2	metacluster_151.2	ZNF23 (directAnnotation).
MSI2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MSI2	jaspar__MA0079.5	SP1 (directAnnotation).
MSI2	transfac_pro__M06074	ZNF732 (directAnnotation).
MSI2	transfac_pro__M04862	NRF1 (directAnnotation).
MSI2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
MSI2	metacluster_141.4	GLIS2 (directAnnotation).
MSI2	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
MSI2	jaspar__MA0776.1	MYBL1 (directAnnotation).
MSI2	metacluster_161.31	PRRX2 (directAnnotation).
MSI2	transfac_pro__M04748	GABPA (directAnnotation).
MSI2	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
MSI2	transfac_public__M00040	ATF2 (directAnnotation).
MSI2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MSI2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MSI2	cisbp__M00968	MTF2 (directAnnotation).
MSI2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MSI2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MSI2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MSI2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MSI2	transfac_pro__M01199	TRIM28 (directAnnotation).
MSI2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MSI2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MSI2	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
MSI2	hdpi__TP73	TP73 (directAnnotation).
MSI2	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
MSI2	transfac_pro__M04950	EGR1 (directAnnotation).
MSI2	transfac_pro__M06249	ZNF616 (directAnnotation).
MSI2	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
MSI2	transfac_pro__M02089	E2F3 (directAnnotation).
MSI2	transfac_pro__M02898	SMAD3 (directAnnotation).
MSI2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MSI2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MSI2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MSI2	hdpi__HIP2	UBE2K (directAnnotation).
MSI2	hdpi__NRL	NRL (directAnnotation).
MSI2	transfac_pro__M00430	E2F1 (directAnnotation).
MSI2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
MSI2	transfac_pro__M07329	SP7 (directAnnotation).
MSI2	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
MSI2	transfac_pro__M07397	ZNF148 (directAnnotation).
MSI2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
MSI2	cisbp__M07938	E2F1 (directAnnotation).
MSI2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
MSI2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MSI2	transfac_pro__M07436	WT1 (directAnnotation).
MSI2	metacluster_3.14	WT1; WT1 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."