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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MOSMO

Summary for MOSMO

Gene information	Gene symbol	MOSMO
	Ensembl ID	ENSG00000284487
	Entrez ID	730094
	Gene name	modulator of smoothened
	Synonyms	ATTHOG\|BC030336\|C16orf52
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MOSMO

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.353302	0.00e+00

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Expression of MOSMO in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MOSMO

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MOSMO

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MOSMO	hsa-miR-411-5p	89.6733	NM_001164579
MOSMO	hsa-miR-19b-3p	89.3539	NM_001164579
MOSMO	hsa-miR-19a-3p	89.3539	NM_001164579
MOSMO	hsa-miR-6782-3p	89.2071	NM_001164579
MOSMO	hsa-miR-656-3p	88.6271	NM_001164579
MOSMO	hsa-miR-548am-3p	88.5569	NM_001164579
MOSMO	hsa-miR-548ah-3p	88.5569	NM_001164579
MOSMO	hsa-miR-548j-3p	88.5569	NM_001164579
MOSMO	hsa-miR-548ae-3p	88.5569	NM_001164579
MOSMO	hsa-miR-548aq-3p	88.5569	NM_001164579
MOSMO	hsa-miR-20a-5p	88.3925	NM_001164579
MOSMO	hsa-miR-106b-5p	88.3925	NM_001164579
MOSMO	hsa-miR-526b-3p	88.1937	NM_001164579
MOSMO	hsa-miR-106a-5p	88.1937	NM_001164579
MOSMO	hsa-miR-7158-5p	88.1904	NM_001164579
MOSMO	hsa-miR-6815-3p	87.5517	NM_001164579
MOSMO	hsa-miR-3119	87.226	NM_001164579
MOSMO	hsa-miR-1277-5p	87.1082	NM_001164579
MOSMO	hsa-miR-6888-5p	86.8845	NM_001164579
MOSMO	hsa-miR-6845-3p	86.8783	NM_001164579
MOSMO	hsa-miR-6867-5p	86.8183	NM_001164579
MOSMO	hsa-miR-153-3p	86.413	NM_001164579
MOSMO	hsa-miR-3140-3p	86.3796	NM_001164579
MOSMO	hsa-miR-5195-3p	86.1245	NM_001164579
MOSMO	hsa-miR-145-5p	86.1245	NM_001164579
MOSMO	hsa-miR-6853-3p	85.5901	NM_001164579
MOSMO	hsa-miR-520g-3p	85.3885	NM_001164579
MOSMO	hsa-miR-520h	85.3885	NM_001164579
MOSMO	hsa-miR-410-3p	85.092	NM_001164579
MOSMO	hsa-miR-4422	85.0464	NM_001164579
MOSMO	hsa-miR-17-5p	84.8384	NM_001164579
MOSMO	hsa-miR-93-5p	84.8384	NM_001164579
MOSMO	hsa-miR-519d-3p	84.8384	NM_001164579
MOSMO	hsa-miR-20b-5p	84.8384	NM_001164579
MOSMO	hsa-miR-548p	83.8121	NM_001164579
MOSMO	hsa-miR-15b-3p	82.9611	NM_001164579
MOSMO	hsa-miR-103a-2-5p	82.7337	NM_001164579
MOSMO	hsa-miR-4789-5p	82.6052	NM_001164579
MOSMO	hsa-miR-6083	82.4495	NM_001164579
MOSMO	hsa-miR-7152-3p	82.3458	NM_001164579
MOSMO	hsa-miR-4516	81.5563	NM_001164579
MOSMO	hsa-miR-5196-5p	80.6061	NM_001164579
MOSMO	hsa-miR-4747-5p	80.6061	NM_001164579
MOSMO	hsa-miR-103a-1-5p	80.339	NM_001164579
MOSMO	hsa-miR-3978	80.1352	NM_001164579
MOSMO	hsa-miR-6742-3p	80.1104	NM_001164579

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Motifs and transcription factors (TFs) regulating MOSMO

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."