Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MINDY2

Summary for MINDY2

Gene information	Gene symbol	MINDY2
	Ensembl ID	ENSG00000128923
	Entrez ID	54629
	Gene name	MINDY lysine 48 deubiquitinase 2
	Synonyms	FAM63B\|KIAA1164
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: MINDY2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.269917	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.313963	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.410479	4.20e-45

Top

Expression of MINDY2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MINDY2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MINDY2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MINDY2	hsa-miR-4477b	96.3538	NM_001040453
MINDY2	hsa-miR-12124	96.2694	NM_001040453
MINDY2	hsa-miR-3920	96.2047	NM_001040453
MINDY2	hsa-miR-590-3p	96.1835	NM_001040453
MINDY2	hsa-miR-6885-3p	96.0866	NM_001040453
MINDY2	hsa-miR-8067	95.9176	NM_001040453
MINDY2	hsa-miR-429	95.2582	NM_001040453
MINDY2	hsa-miR-200c-3p	95.2582	NM_001040453
MINDY2	hsa-miR-200b-3p	95.2582	NM_001040453
MINDY2	hsa-miR-3658	95.2258	NM_001040453
MINDY2	hsa-miR-4775	95.2193	NM_001040453
MINDY2	hsa-miR-3163	94.7845	NM_001040453
MINDY2	hsa-miR-4698	94.5169	NM_001040453
MINDY2	hsa-miR-4267	94.4367	NM_001040453
MINDY2	hsa-miR-6715b-5p	94.0357	NM_001040453
MINDY2	hsa-miR-4269	94.0357	NM_001040453
MINDY2	hsa-miR-425-5p	93.9911	NM_001040453
MINDY2	hsa-miR-4760-5p	93.8373	NM_001040453
MINDY2	hsa-miR-3942-3p	93.7416	NM_001040453
MINDY2	hsa-miR-889-3p	93.6689	NM_001040453
MINDY2	hsa-miR-561-3p	93.5114	NM_001040453
MINDY2	hsa-miR-6818-5p	93.0561	NM_001040453
MINDY2	hsa-miR-95-5p	92.8664	NM_001040453
MINDY2	hsa-miR-203a-3p	92.44	NM_001040453
MINDY2	hsa-miR-582-5p	92.3571	NM_001040453
MINDY2	hsa-miR-508-3p	92.2816	NM_001040453
MINDY2	hsa-miR-548ar-3p	92.144	NM_001040453
MINDY2	hsa-miR-4310	92.0409	NM_001040453
MINDY2	hsa-miR-4796-3p	91.9514	NM_001040453
MINDY2	hsa-miR-1304-5p	91.9286	NM_001040453
MINDY2	hsa-miR-653-3p	91.8493	NM_001040453
MINDY2	hsa-miR-190b-3p	91.6424	NM_001040453
MINDY2	hsa-miR-8084	91.5074	NM_001040453
MINDY2	hsa-miR-548aj-3p	91.4247	NM_001040453
MINDY2	hsa-miR-548x-3p	91.4247	NM_001040453
MINDY2	hsa-miR-3148	91.2503	NM_001040453
MINDY2	hsa-miR-218-1-3p	91.2467	NM_001040453
MINDY2	hsa-miR-6516-3p	91.1838	NM_001040453
MINDY2	hsa-miR-10527-5p	91.0777	NM_001040453
MINDY2	hsa-miR-548a-3p	90.8958	NM_001040453
MINDY2	hsa-miR-491-3p	90.8589	NM_001040453
MINDY2	hsa-miR-548e-3p	90.8232	NM_001040453
MINDY2	hsa-miR-548f-3p	90.8232	NM_001040453
MINDY2	hsa-miR-548bc	90.8232	NM_001040453
MINDY2	hsa-miR-548az-3p	90.8232	NM_001040453
MINDY2	hsa-miR-150-5p	90.6378	NM_001040453
MINDY2	hsa-miR-8068	90.2975	NM_001040453
MINDY2	hsa-miR-335-3p	90.2048	NM_001040453
MINDY2	hsa-miR-659-3p	89.975	NM_001040453
MINDY2	hsa-miR-4692	89.923	NM_001040453

Page: 1 2 3 4

Top

Motifs and transcription factors (TFs) regulating MINDY2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."