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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MIB1

Summary for MIB1

Gene information	Gene symbol	MIB1
	Ensembl ID	ENSG00000101752
	Entrez ID	57534
	Gene name	MIB E3 ubiquitin protein ligase 1
	Synonyms	DIP-1\|KIAA1323\|MIB\|ZZANK2\|ZZZ6
	Gene type	protein_coding
	UniProtAcc	Q86YT6

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Dataset with differentially expressed gene: MIB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.917494	2.15e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.262182	2.04e-14
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.262443	3.69e-12

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Expression of MIB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MIB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MIB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MIB1	hsa-miR-6891-5p	89.1069	NM_020774
MIB1	hsa-miR-3173-3p	89.1069	NM_020774
MIB1	hsa-miR-12118	89.1069	NM_020774
MIB1	hsa-miR-33a-3p	89.0156	NM_020774
MIB1	hsa-miR-520d-5p	88.9569	NM_020774
MIB1	hsa-miR-524-5p	88.9569	NM_020774
MIB1	hsa-miR-200c-3p	88.7966	NM_020774
MIB1	hsa-miR-200b-3p	88.7966	NM_020774
MIB1	hsa-miR-429	88.7966	NM_020774
MIB1	hsa-miR-3677-5p	88.5507	NM_020774
MIB1	hsa-miR-4328	88.0574	NM_020774
MIB1	hsa-miR-670-3p	87.7857	NM_020774
MIB1	hsa-miR-5702	87.7049	NM_020774
MIB1	hsa-miR-7-2-3p	87.1432	NM_020774
MIB1	hsa-miR-7-1-3p	87.1432	NM_020774
MIB1	hsa-miR-12127	86.8866	NM_020774
MIB1	hsa-miR-149-5p	86.6415	NM_020774
MIB1	hsa-miR-3145-3p	86.1435	NM_020774
MIB1	hsa-miR-302e	85.9451	NM_020774
MIB1	hsa-miR-590-3p	85.7689	NM_020774
MIB1	hsa-miR-4428	84.8727	NM_020774
MIB1	hsa-miR-4475	84.2612	NM_020774
MIB1	hsa-miR-6856-3p	82.728	NM_020774
MIB1	hsa-miR-4724-5p	82.5734	NM_020774
MIB1	hsa-miR-4698	82.3023	NM_020774
MIB1	hsa-miR-548e-5p	82.0476	NM_020774
MIB1	hsa-miR-4719	81.8661	NM_020774
MIB1	hsa-miR-4694-5p	81.7976	NM_020774
MIB1	hsa-miR-6779-3p	81.7161	NM_020774
MIB1	hsa-miR-340-5p	81.6682	NM_020774
MIB1	hsa-miR-4738-3p	81.6035	NM_020774
MIB1	hsa-miR-3140-5p	81.5536	NM_020774
MIB1	hsa-miR-202-5p	81.4578	NM_020774
MIB1	hsa-miR-4480	81.3976	NM_020774
MIB1	hsa-miR-6124	81.344	NM_020774
MIB1	hsa-miR-4802-3p	81.0374	NM_020774
MIB1	hsa-miR-519e-5p	81.014	NM_020774
MIB1	hsa-miR-515-5p	81.014	NM_020774
MIB1	hsa-miR-5684	80.8739	NM_020774
MIB1	hsa-miR-15a-5p	80.7759	NM_020774
MIB1	hsa-miR-195-5p	80.7759	NM_020774
MIB1	hsa-miR-15b-5p	80.7759	NM_020774
MIB1	hsa-miR-16-5p	80.7759	NM_020774
MIB1	hsa-miR-302d-3p	80.6148	NM_020774
MIB1	hsa-miR-302c-3p	80.6148	NM_020774
MIB1	hsa-miR-302b-3p	80.6148	NM_020774
MIB1	hsa-miR-302a-3p	80.6148	NM_020774
MIB1	hsa-miR-511-5p	80.585	NM_020774
MIB1	hsa-miR-4490	80.5584	NM_020774
MIB1	hsa-miR-6885-3p	80.4819	NM_020774

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Motifs and transcription factors (TFs) regulating MIB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MIB1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
MIB1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
MIB1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
MIB1	transfac_pro__M04617	ZBTB7A (directAnnotation).
MIB1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MIB1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MIB1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MIB1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MIB1	cisbp__M00341	PAX6 (directAnnotation).
MIB1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MIB1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MIB1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MIB1	metacluster_175.1	ZNF283 (directAnnotation).
MIB1	jaspar__MA0079.5	SP1 (directAnnotation).
MIB1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
MIB1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
MIB1	hdpi__NFIX	NFIX (directAnnotation).
MIB1	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
MIB1	transfac_pro__M05712	ZNF134 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."