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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor

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Acts as a drug target< (This gene does not contain this module)

Gene: MEF2C

Summary for MEF2C

Gene informationGene symbol

MEF2C

Ensembl ID

ENSG00000081189

Entrez ID

4208

Gene namemyocyte enhancer factor 2C
SynonymsNA
Gene typeprotein_coding
UniProtAcc

Q06413


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Dataset with differentially expressed gene: MEF2C

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells0.6616590.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostMono/Macro-0.2928992.43e-14

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro-0.3975732.26e-11

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.4019642.31e-08

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells0.5730852.20e-39

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostPlasma cells-0.4545338.87e-09

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMono/Macro0.5050935.29e-37

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.5968380.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostMalignant cells-0.6744316.20e-36

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMalignant cells-0.4176218.40e-31

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostcDCs0.3263012.22e-08

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreMalignant cells-0.3901180.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreB cells0.3056521.32e-07

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells-0.328760.00e+00

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Expression of MEF2C in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to MEF2C

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MEF2C

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
MEF2Chsa-miR-338-5p93.2096NM_001193350
MEF2Chsa-miR-128393.1979NM_001308002
MEF2Chsa-miR-3688-3p93.09NM_001308002
MEF2Chsa-miR-608393.0742NM_001193350
MEF2Chsa-miR-469892.4366NM_001193350
MEF2Chsa-miR-447591.9823NM_001308002
MEF2Chsa-miR-4769-5p91.9804NM_001308002
MEF2Chsa-miR-465491.9355NM_001308002
MEF2Chsa-miR-106a-3p91.9307NM_001193350
MEF2Chsa-miR-428891.7797NM_001193350
MEF2Chsa-miR-612491.5549NM_001308002
MEF2Chsa-miR-153-5p91.2105NM_001193350
MEF2Chsa-miR-316791.0304NM_001193350
MEF2Chsa-miR-7162-3p90.9847NM_001308002
MEF2Chsa-miR-522-3p90.7438NM_001193350
MEF2Chsa-miR-224-3p90.7438NM_001193350
MEF2Chsa-miR-548n90.6502NM_001193350
MEF2Chsa-miR-715090.5851NM_001308002
MEF2Chsa-miR-3156-3p90.4466NM_001193350
MEF2Chsa-miR-4722-5p90.3166NM_001308002
MEF2Chsa-miR-3680-3p90.14NM_001308002
MEF2Chsa-miR-182-5p89.659NM_001308002
MEF2Chsa-miR-6882-5p89.6255NM_001308002
MEF2Chsa-miR-876-5p89.3174NM_001193350
MEF2Chsa-miR-1295b-5p89.283NM_001308002
MEF2Chsa-miR-1912-3p89.283NM_001308002
MEF2Chsa-miR-453089.1407NM_001308002
MEF2Chsa-miR-805489.0849NM_001308002
MEF2Chsa-miR-548k89.0849NM_001308002
MEF2Chsa-miR-548av-5p89.0849NM_001308002
MEF2Chsa-miR-63289.0184NM_001193350
MEF2Chsa-miR-7845-5p88.9413NM_001308002
MEF2Chsa-miR-548z88.8876NM_001193350
MEF2Chsa-miR-548bb-3p88.8876NM_001193350
MEF2Chsa-miR-548h-3p88.8876NM_001193350
MEF2Chsa-miR-548d-3p88.8876NM_001193350
MEF2Chsa-miR-548ac88.8876NM_001193350
MEF2Chsa-miR-4666a-5p88.8486NM_001193350
MEF2Chsa-miR-313388.5696NM_001308002
MEF2Chsa-miR-449588.2702NM_001193350
MEF2Chsa-miR-130b-5p88.1843NM_001193350
MEF2Chsa-miR-147b-5p87.4983NM_001308002
MEF2Chsa-miR-4668-5p87.4672NM_001308002
MEF2Chsa-let-7f-1-3p87.4565NM_001308002
MEF2Chsa-let-7a-3p87.4565NM_001308002
MEF2Chsa-let-7b-3p87.4565NM_001308002
MEF2Chsa-miR-98-3p87.4565NM_001308002
MEF2Chsa-miR-188-5p87.3894NM_001193350
MEF2Chsa-miR-6866-3p87.3894NM_001193350
MEF2Chsa-miR-6823-3p87.1277NM_001193350
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Motifs and transcription factors (TFs) regulating MEF2C

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
MEF2Chdpi__ZNF193ZSCAN9 (directAnnotation).
MEF2Ctransfac_pro__M06074ZNF732 (directAnnotation).
MEF2Cjaspar__MA1106.1HIF1A (directAnnotation).
MEF2Chocomoco__OTX1_HUMAN.H11MO.0.DOTX1 (directAnnotation).
MEF2Ctransfac_pro__M02843BBX (inferredBy_Orthology).
MEF2Cjaspar__MA1483.2ELF2 (directAnnotation).
MEF2Cmetacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MEF2Ctaipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
MEF2Cmetacluster_174.2CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MEF2Ctaipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAPETV5; HOXA2 (directAnnotation).
MEF2Cmetacluster_166.2ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
MEF2Cswissregulon__hs__ELF2ELF2 (directAnnotation).
MEF2Cmetacluster_191.3EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MEF2Chdpi__TP73TP73 (directAnnotation).
MEF2Cmetacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MEF2Ctaipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_reprERF; FOXI1 (directAnnotation).
MEF2Ctaipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAPETV4; TEAD4 (directAnnotation).
MEF2Ctaipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAPETV4; FOXO1 (directAnnotation).
MEF2Cswissregulon__mm__E2f7E2F7 (inferredBy_Orthology).
MEF2Ctransfac_pro__M04826EP300 (directAnnotation).
MEF2Ctaipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAPELK3; FOXO1 (directAnnotation).
MEF2Ctransfac_pro__M04950EGR1 (directAnnotation).
MEF2Ctaipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAPETV1; TEAD4 (directAnnotation).
MEF2Ctransfac_pro__M01182HINFP (directAnnotation).
MEF2Chdpi__FLI1FLI1 (directAnnotation).
MEF2Ctransfac_pro__M04862NRF1 (directAnnotation).
MEF2Cjaspar__MA1708.1ETV7 (directAnnotation).
MEF2Ctaipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAPERG; TEAD4 (directAnnotation).
MEF2Ctaipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAPETV5; FOXI1 (directAnnotation).
MEF2Ctaipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_reprERG; TEAD4 (directAnnotation).
MEF2Ctaipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAPETV2; FOXO6 (directAnnotation).
MEF2Cmetacluster_34.3EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
MEF2Ctaipale_tf_pairs__ELF2_NATGCGGAAGTR_HTELF2 (directAnnotation).
MEF2Chdpi__ETV4ETV4 (directAnnotation).
MEF2Ctaipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAPETV4; HOXB2 (directAnnotation).
MEF2Ctaipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAPETV2; FOXI1 (directAnnotation).
MEF2Ctaipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAPFLI1; FOXI1 (directAnnotation).
MEF2Ctaipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_reprMAX; TFAP2C (directAnnotation).
MEF2Ctransfac_pro__M01298MECP2 (directAnnotation).
MEF2Ctransfac_pro__M01029MITF; TFE3; TFEB; TFEC (directAnnotation).
MEF2Ccisbp__M01738BHLHE40 (inferredBy_Orthology).
MEF2Ctransfac_pro__M05916ZNF407 (directAnnotation).
MEF2Ctfdimers__MD00527IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation).
MEF2Ctransfac_pro__M06751ZNF510 (directAnnotation).
MEF2Ctfdimers__MD00217LTF; MZF1 (directAnnotation).
MEF2Ctransfac_pro__M06117ZNF23 (directAnnotation).
MEF2Cmetacluster_162.5NR1D1; NR1D1; RORA; RORA; RORA; RORA; RORA; RORC; RORC (directAnnotation). NR1D1; PPARG; RORA; RORC (inferredBy_Orthology).
MEF2Chdpi__ZNF131ZNF131 (directAnnotation).
MEF2Ctaipale_tf_pairs__ELK1_EVX1_RSCGGWANNNNYMATTA_CAP_reprELK1; EVX1 (directAnnotation).
MEF2Cjaspar__MA1108.2MXI1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.
TFmotifExpressionCell typeDatasetTimepoint
MEF2Cmetacluster_132.4downMono/Macro

GSE169246_PacTissue

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."