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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MED13

Summary for MED13

Gene information	Gene symbol	MED13
	Ensembl ID	ENSG00000108510
	Entrez ID	9969
	Gene name	mediator complex subunit 13
	Synonyms	KIAA0593\|THRAP1\|TRAP240
	Gene type	protein_coding
	UniProtAcc	Q9UHV7

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Dataset with differentially expressed gene: MED13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.303643	4.04e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.292323	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.558318	8.15e-31

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Expression of MED13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MED13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MED13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MED13	hsa-miR-5581-3p	92.1524	NM_005121
MED13	hsa-miR-497-3p	92.0651	NM_005121
MED13	hsa-miR-4786-3p	91.6876	NM_005121
MED13	hsa-miR-338-5p	91.6758	NM_005121
MED13	hsa-miR-1253	91.4547	NM_005121
MED13	hsa-miR-4778-5p	91.2981	NM_005121
MED13	hsa-miR-374a-5p	91.2854	NM_005121
MED13	hsa-miR-19a-3p	91.0909	NM_005121
MED13	hsa-miR-19b-3p	91.0909	NM_005121
MED13	hsa-miR-664a-3p	90.6978	NM_005121
MED13	hsa-miR-875-3p	90.6173	NM_005121
MED13	hsa-miR-548g-3p	90.3144	NM_005121
MED13	hsa-miR-670-3p	90.2998	NM_005121
MED13	hsa-miR-4705	90.1119	NM_005121
MED13	hsa-miR-5003-3p	89.7792	NM_005121
MED13	hsa-miR-224-5p	89.5549	NM_005121
MED13	hsa-miR-891b	89.5413	NM_005121
MED13	hsa-miR-548h-3p	88.9962	NM_005121
MED13	hsa-miR-548bb-3p	88.9962	NM_005121
MED13	hsa-miR-548z	88.9962	NM_005121
MED13	hsa-miR-548ac	88.9962	NM_005121
MED13	hsa-miR-548d-3p	88.9962	NM_005121
MED13	hsa-miR-374b-5p	88.6681	NM_005121
MED13	hsa-miR-3148	88.1205	NM_005121
MED13	hsa-miR-140-5p	87.7852	NM_005121
MED13	hsa-miR-1537-5p	87.7751	NM_005121
MED13	hsa-miR-7111-3p	87.755	NM_005121
MED13	hsa-miR-6872-3p	87.6542	NM_005121
MED13	hsa-miR-12127	87.1787	NM_005121
MED13	hsa-miR-6885-3p	87.0061	NM_005121
MED13	hsa-miR-451b	86.9414	NM_005121
MED13	hsa-miR-499a-5p	86.8065	NM_005121
MED13	hsa-miR-340-5p	86.1702	NM_005121
MED13	hsa-miR-541-5p	86.1169	NM_005121
MED13	hsa-miR-12123	86.0388	NM_005121
MED13	hsa-miR-4326	85.9048	NM_005121
MED13	hsa-miR-4460	85.5909	NM_005121
MED13	hsa-miR-4693-5p	85.5894	NM_005121
MED13	hsa-miR-181b-2-3p	85.4138	NM_005121
MED13	hsa-miR-181b-3p	85.4138	NM_005121
MED13	hsa-miR-4420	85.4138	NM_005121
MED13	hsa-miR-493-5p	85.1813	NM_005121
MED13	hsa-miR-410-3p	85.0291	NM_005121
MED13	hsa-miR-655-5p	84.7153	NM_005121
MED13	hsa-miR-3926	84.4235	NM_005121
MED13	hsa-miR-144-3p	84.3056	NM_005121
MED13	hsa-miR-3935	84.261	NM_005121
MED13	hsa-miR-6504-3p	84.1988	NM_005121
MED13	hsa-miR-10399-5p	84.1988	NM_005121
MED13	hsa-miR-4793-5p	84.1473	NM_005121

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Motifs and transcription factors (TFs) regulating MED13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MED13	metacluster_135.11	NR2C2 (directAnnotation).
MED13	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MED13	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MED13	metacluster_7.13	ZFX (directAnnotation).
MED13	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MED13	cisbp__M00968	MTF2 (directAnnotation).
MED13	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MED13	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MED13	cisbp__M00341	PAX6 (directAnnotation).
MED13	metacluster_198.3	ZFP64 (directAnnotation).
MED13	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MED13	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MED13	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MED13	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MED13	cisbp__M00788	ZFY (inferredBy_Orthology).
MED13	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MED13	metacluster_175.1	ZNF283 (directAnnotation).
MED13	hdpi__ZNF304	ZNF304 (directAnnotation).
MED13	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MED13	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MED13	transfac_pro__M01199	TRIM28 (directAnnotation).
MED13	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
MED13	metacluster_151.2	ZNF23 (directAnnotation).
MED13	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MED13	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MED13	transfac_pro__M03806	ZBTB7C (directAnnotation).
MED13	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MED13	jaspar__MA0502.2	NFYB (directAnnotation).
MED13	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MED13	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
MED13	cisbp__M00249	WT1 (directAnnotation).
MED13	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MED13	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MED13	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MED13	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MED13	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
MED13	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
MED13	jaspar__MA1721.1	ZNF93 (directAnnotation).
MED13	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
MED13	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MED13	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
MED13	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
MED13	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
MED13	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MED13	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MED13	jaspar__MA0748.2	YY2 (directAnnotation).
MED13	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MED13	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MED13	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
MED13	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."