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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MBNL2

Summary for MBNL2

Gene information	Gene symbol	MBNL2
	Ensembl ID	ENSG00000139793
	Entrez ID	10150
	Gene name	muscleblind like splicing regulator 2
	Synonyms	MBLL\|MBLL39
	Gene type	protein_coding
	UniProtAcc	Q5VZF2

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Dataset with differentially expressed gene: MBNL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.66946	1.28e-16
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.326725	2.41e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.274803	2.88e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.35	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.691229	0.00e+00

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Expression of MBNL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MBNL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MBNL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MBNL2	hsa-miR-548au-5p	93.5715	NM_144778
MBNL2	hsa-miR-548w	93.5715	NM_144778
MBNL2	hsa-miR-548bb-5p	93.5715	NM_144778
MBNL2	hsa-miR-548j-5p	93.5715	NM_144778
MBNL2	hsa-miR-875-3p	93.4814	NM_001306070
MBNL2	hsa-miR-4639-5p	92.965	NM_144778
MBNL2	hsa-miR-1299	92.1875	NM_001306070
MBNL2	hsa-miR-1290	92.1612	NM_001306070
MBNL2	hsa-miR-432-5p	92.1587	NM_144778
MBNL2	hsa-miR-5692c	92.1234	NM_001306070
MBNL2	hsa-miR-5692b	92.1234	NM_001306070
MBNL2	hsa-miR-660-3p	91.0474	NM_144778
MBNL2	hsa-miR-203b-3p	90.9417	NM_001306070
MBNL2	hsa-miR-3201	90.8404	NM_001306070
MBNL2	hsa-miR-3529-3p	90.576	NM_001306070
MBNL2	hsa-miR-7154-5p	90.2634	NM_001306070
MBNL2	hsa-miR-6753-3p	90.1256	NM_144778
MBNL2	hsa-miR-7107-3p	90.1256	NM_144778
MBNL2	hsa-miR-4724-3p	90.0268	NM_144778
MBNL2	hsa-miR-520f-3p	89.8987	NM_001306070
MBNL2	hsa-miR-4662a-3p	89.7312	NM_144778
MBNL2	hsa-miR-590-3p	89.6084	NM_001306070
MBNL2	hsa-miR-369-3p	89.5057	NM_001306070
MBNL2	hsa-miR-548c-3p	89.4873	NM_001306070
MBNL2	hsa-miR-203a-3p	88.9346	NM_144778
MBNL2	hsa-miR-636	88.3823	NM_144778
MBNL2	hsa-miR-4791	88.1143	NM_001306070
MBNL2	hsa-miR-6806-3p	88.101	NM_001306070
MBNL2	hsa-miR-3928-5p	88.101	NM_001306070
MBNL2	hsa-miR-3657	87.8112	NM_144778
MBNL2	hsa-miR-510-3p	87.6886	NM_001306070
MBNL2	hsa-miR-3692-3p	87.1506	NM_001306070
MBNL2	hsa-miR-1468-3p	87.1186	NM_001306070
MBNL2	hsa-miR-1252-3p	86.7304	NM_144778
MBNL2	hsa-miR-1267	86.7302	NM_144778
MBNL2	hsa-miR-367-5p	86.7302	NM_144778
MBNL2	hsa-miR-4422	86.546	NM_144778
MBNL2	hsa-miR-552-3p	86.5027	NM_001306070
MBNL2	hsa-miR-6834-5p	85.9358	NM_001306070
MBNL2	hsa-miR-548ap-3p	85.4907	NM_144778
MBNL2	hsa-miR-548aa	85.4907	NM_144778
MBNL2	hsa-miR-548t-3p	85.4907	NM_144778
MBNL2	hsa-miR-12136	85.4	NM_001306070
MBNL2	hsa-miR-4645-3p	85.3948	NM_001306070
MBNL2	hsa-miR-3684	85.2617	NM_144778
MBNL2	hsa-miR-329-5p	84.9552	NM_144778
MBNL2	hsa-miR-4262	84.7577	NM_144778
MBNL2	hsa-miR-381-3p	84.676	NM_144778
MBNL2	hsa-miR-300	84.676	NM_144778
MBNL2	hsa-miR-218-5p	84.5474	NM_144778

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Motifs and transcription factors (TFs) regulating MBNL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MBNL2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
MBNL2	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
MBNL2	transfac_pro__M06156	ZNF75D (directAnnotation).
MBNL2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MBNL2	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
MBNL2	cisbp__M00808	MYPOP (inferredBy_Orthology).
MBNL2	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
MBNL2	jaspar__MA0502.2	NFYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."