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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MBD2

Summary for MBD2

Gene information	Gene symbol	MBD2
	Ensembl ID	ENSG00000134046
	Entrez ID	8932
	Gene name	methyl-CpG binding domain protein 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9UBB5

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Dataset with differentially expressed gene: MBD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	-0.390508	1.82e-44
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.302924	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.34193	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.292506	0.00e+00

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Expression of MBD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MBD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MBD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MBD2	hsa-miR-520c-3p	85.595	NM_003927
MBD2	hsa-miR-520d-3p	85.595	NM_003927
MBD2	hsa-miR-372-3p	85.595	NM_003927
MBD2	hsa-miR-520b-3p	85.595	NM_003927
MBD2	hsa-miR-4447	85.3045	NM_003927
MBD2	hsa-miR-6809-5p	85.1253	NM_003927
MBD2	hsa-miR-548p	84.5812	NM_015832
MBD2	hsa-miR-4698	84.5201	NM_003927
MBD2	hsa-miR-8063	84.5201	NM_003927
MBD2	hsa-miR-7151-3p	84.4536	NM_003927
MBD2	hsa-miR-3613-3p	83.7752	NM_003927
MBD2	hsa-miR-3124-3p	83.4991	NM_003927
MBD2	hsa-miR-98-5p	83.2734	NM_003927
MBD2	hsa-let-7g-5p	83.2734	NM_003927
MBD2	hsa-let-7c-5p	83.2734	NM_003927
MBD2	hsa-let-7i-5p	83.2734	NM_003927
MBD2	hsa-let-7e-5p	83.2734	NM_003927
MBD2	hsa-let-7f-5p	83.2734	NM_003927
MBD2	hsa-let-7b-5p	83.2734	NM_003927
MBD2	hsa-let-7a-5p	83.2734	NM_003927
MBD2	hsa-miR-3910	83.0889	NM_003927
MBD2	hsa-miR-4458	82.2951	NM_003927
MBD2	hsa-let-7d-5p	82.2951	NM_003927
MBD2	hsa-miR-4719	82.2066	NM_003927
MBD2	hsa-miR-217-5p	82.0723	NM_003927
MBD2	hsa-miR-6807-3p	81.8737	NM_003927
MBD2	hsa-miR-3652	81.6012	NM_003927
MBD2	hsa-miR-4430	81.6012	NM_003927
MBD2	hsa-miR-450a-2-3p	81.1084	NM_003927
MBD2	hsa-miR-4718	81.0854	NM_003927
MBD2	hsa-miR-12136	81.0006	NM_003927
MBD2	hsa-miR-3168	80.607	NM_003927
MBD2	hsa-miR-10527-5p	80.1945	NM_015832
MBD2	hsa-miR-3605-5p	80.1423	NM_003927
MBD2	hsa-miR-208b-5p	80.0891	NM_003927
MBD2	hsa-miR-208a-5p	80.0891	NM_003927

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Motifs and transcription factors (TFs) regulating MBD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MBD2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MBD2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
MBD2	transfac_pro__M04950	EGR1 (directAnnotation).
MBD2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MBD2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
MBD2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MBD2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
MBD2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MBD2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MBD2	transfac_pro__M00652	NRF1 (directAnnotation).
MBD2	hdpi__ETV4	ETV4 (directAnnotation).
MBD2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MBD2	transfac_pro__M04866	HDAC2 (directAnnotation).
MBD2	jaspar__MA1122.1	TFDP1 (directAnnotation).
MBD2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
MBD2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MBD2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MBD2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
MBD2	metacluster_29.6	ZNF436 (directAnnotation).
MBD2	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
MBD2	transfac_pro__M05853	ZNF548 (directAnnotation).
MBD2	metacluster_131.3	ZNF436 (inferredBy_Orthology).
MBD2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MBD2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MBD2	cisbp__M00249	WT1 (directAnnotation).
MBD2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MBD2	transfac_pro__M01122	ZNF219 (directAnnotation).
MBD2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MBD2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MBD2	metacluster_7.13	ZFX (directAnnotation).
MBD2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MBD2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
MBD2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MBD2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MBD2	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
MBD2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
MBD2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MBD2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MBD2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
MBD2	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
MBD2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MBD2	metacluster_84.2	RARA (directAnnotation).
MBD2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MBD2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
MBD2	transfac_pro__M01253	CNOT3 (directAnnotation).
MBD2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
MBD2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MBD2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MBD2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MBD2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MBD2	metacluster_174.3	down	Malignant cells	GSE139386	NA
MBD2	metacluster_174.3	down	Malignant cells	GSE139386	NA
MBD2	metacluster_174.3	up	Malignant cells	GSE189460	pre
MBD2	metacluster_135.10	down	Malignant cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."